Bipolar Disorder clinical trials
The registry lists 1,599 studies for Bipolar Disorder across more than 10 countries. 253 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 1,009
- Recruiting
- 199
- Status unknown
- 135
- Terminated
- 114
- Not yet recruiting
- 41
- Withdrawn
- 41
Phase
- Phase 3
- 231
- Phase 4
- 224
- Phase 2
- 159
- Phase 1
- 70
- Early Phase 1
- 11
Where
- United States
- 809
- Canada
- 125
- France
- 93
- China
- 77
- Denmark
- 46
- Spain
- 46
Who runs them
Massachusetts General Hospital (63) · AstraZeneca (47) · National Institute of Mental Health (NIMH) (37) · Mclean Hospital (31) · Stanford University (22) · University of Pittsburgh (22) · University Hospitals Cleveland Medical Center (21) · University of Texas Southwestern Medical Center (21)
Studies
Recruiting first, then most recently updated. Showing 50 of 1,599 — search for more.
- Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum DisorderRecruitingNCT06229210Phase 33 countries
- Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric PatientsRecruitingNCT06372964Phase 34 countries
- Neuromodulation of Mood Switch Circuitry in Bipolar DisorderRecruitingNCT07680153Phase 41 country
- Cognition and Affective Research in ChinaNot yet recruitingNCT078332671 country
- A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)RecruitingNCT07286175Phase 28 countries
- Safety and Feasibility of DBS for Bipolar DepressionRecruitingNCT07745374Not applicable1 country
- Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment AreaNot yet recruitingNCT07570875Not applicable1 country
- Neuro-computational Study of Thymic Fluctuations in Mood DisordersRecruitingNCT07033923Not applicable1 country
- Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to TreatmentRecruitingNCT07741981Not applicable1 country
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) InhibitorRecruitingNCT07105111Phase 41 country
- A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar DisorderRecruitingNCT07071532Phase 11 country
- OSU6162 in Bipolar Depression (OBID)RecruitingNCT05296356Phase 21 country
- Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II DisorderRecruitingNCT06943573Phase 21 country
- The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar DepressionRecruitingNCT07699445Phase 41 country
- Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar DisorderNot yet recruitingNCT07806227Phase 41 country
- The PEDAL Intervention - Reducing Affective Lability in Bipolar DisorderRecruitingNCT07239778Phase 21 country
- An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)Enrolling by invitationNCT07217860Phase 31 country
- A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)RecruitingNCT07172516Phase 34 countries
- Identifying Biomarkers of Response to Digital Interventions for Mood DisordersEnrolling by invitationNCT07783633Not applicable1 country
- Brexpiprazole Treatment for Bipolar I DepressionRecruitingNCT04569448Phase 31 country
- Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.Not yet recruitingNCT07771517
- COMpassion for Psychiatric Disorders And Self-StigmaRecruitingNCT05698589Not applicable1 country
- Enhancing Veteran-Clinical Collaboration in VA PRRCsRecruitingNCT06898879Not applicable1 country
- Open Label Extension Study of NCT06221852Enrolling by invitationNCT06558201Not applicable1 country
- Ketogenic and Nutritional Interventions for First Episode Bipolar DisorderRecruitingNCT06221852Not applicable1 country
- Ketogenic Intervention for Bipolar DepressionRecruitingNCT07121894Not applicable1 country
- Natural History of Depression, Bipolar Disorder and Suicide RiskRecruitingNCT064621961 country
- A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II DisorderRecruitingNCT06696755Phase 21 country
- NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderRecruitingNCT056697031 country
- Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive TherapyRecruitingNCT06529029Phase 2/31 country
- Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityRecruitingNCT06706232Phase 21 country
- Evaluation of Patients With Mood and Anxiety Disorders and Healthy VolunteersRecruitingNCT000246351 country
- Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar DisorderRecruitingNCT05025605Phase 11 country
- Healthy Lifestyles for Bipolar DisorderRecruitingNCT06188754Not applicable1 country
- Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar DisorderRecruitingNCT07437833Not applicable1 country
- Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care PlatformNot yet recruitingNCT07556861Not applicable1 country
- Prediction on the Recurrence of Manic and Depressive Episodes in Bipolar DisorderRecruitingNCT058280561 country
- EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECTRecruitingNCT077406941 country
- Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory ModelsNot yet recruitingNCT07732933Not applicable1 country
- Biocollection on Peripheral InflammationRecruitingNCT059344741 country
- Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)RecruitingNCT07569198Phase 21 country
- Emotional Eating, Sleep Quality, Mental State and Metabolic SyndromeRecruitingNCT074112221 country
- Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECTRecruitingNCT07534475Not applicable1 country
- Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar DisorderRecruitingNCT06274567Not applicable1 country
- Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective DisorderRecruitingNCT06560749Not applicable1 country
- Exercise and Olanzapine-samidorphanRecruitingNCT06740890Phase 41 country
- The Effect of Comorbid Alcohol/Substance UseRecruitingNCT076929841 country
- A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental IllnessRecruitingNCT05537376Not applicable1 country
- Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - BiomarkersRecruitingNCT076849111 country
- Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic DepressionNot yet recruitingNCT07664852Phase 31 country