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Heart Defects, Congenital clinical trials

The registry lists 991 studies for Heart Defects, Congenital across more than 10 countries. 251 are recruiting or about to start. 722 of them are mainly about Heart Defects, Congenital (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 23 narrower conditions too, such as Ductus Arteriosus, Patent: 2,084 studies, 548 open.

ClinicalTrials.gov finds 3,244 studies for Heart Defects, Congenital. How that becomes 990 here

This page counts the studies the registry files under Heart Defects, Congenital, and those it files under no condition that list Heart Defects, Congenitalthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 3,244Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −1,039Filed under a narrower condition, counted on its own pageForamen Ovale, Patent 133 · Ductus Arteriosus, Patent 126 · Turner Syndrome 122 · Long QT Syndrome 98 · Bicuspid Aortic Valve Disease 58 · Tetralogy of Fallot 56 · 16 more
  3. −74List Heart Defects, Congenital as a condition, but the registry did not file them under itMost often written as “Congenital Heart Disease in Children” (30), “Complex Congenital Heart Disease” (9), and “Cyanotic Congenital Heart Disease” (5). The registry filed 54 of them under no condition at all, and the others under other conditions only, most often Motor Activity (2) and Brain Injuries (1).
  4. −1,141Match it another way62 name it in the title, 3 in a keyword, and 1,076 by a synonym or other text the search reads.
  5. 990The count on this page

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Status

Completed
492
Recruiting
154
Status unknown
121
Not yet recruiting
80
Terminated
55
Active, not recruiting
38

Phase

Phase 2
68
Phase 3
47
Phase 1
32
Phase 4
26
Early Phase 1
6

Where

United States
356
Canada
90
China
79
France
73
Germany
38
United Kingdom
32

Who runs them

Boston Children's Hospital (37) · Emory University (31) · Assiut University (26) · The Hospital for Sick Children (22) · National Heart, Lung, and Blood Institute (NHLBI) (20) · University Hospital, Montpellier (19) · University of Alberta (18) · Children's Hospital Medical Center, Cincinnati (14)

What is being tested here

Drugs under test in Heart Defects, Congenital studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Dapagliflozin202
Nitric Oxide156
Empagliflozin123
Simvastatin102
Lidocaine101
Sotatercept101
Tirzepatide101
Dextromethorphan101
Heparin101
Bivalirudin101

Drug classes tested here SGLT2 inhibitors 3 open · Endothelin receptor antagonists 6 · PDE5 inhibitors 5 · Inhaled anesthetics 5 · Corticosteroids 4

Coming up

7phase 3 studies under way
85studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 154 Heart Defects, Congenital studies recruiting now, 67 (44%) set no upper age limit and 79 (51%) stop at 75 or younger. 110 (71%) take children under 18. 7 (5%) are for women only and 0 (0%) for men only; 25 (16%) take healthy volunteers.

Recruiting studies that take each age, of 154
AgeWomenMen
1066 (43%)66 (43%)
18104 (68%)97 (63%)
3084 (55%)77 (50%)
4083 (54%)76 (49%)
5080 (52%)73 (47%)
6576 (49%)69 (45%)
7576 (49%)69 (45%)
8570 (45%)63 (41%)

Across all 991 studies, recruiting or not: 64% stop at 75 or younger and 63% at 65; 80% take children; 3% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Heart Defects, Congenital studies take

Of 223 interventional studies with no phase under Heart Defects, Congenital, half reached primary completion within 34 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase34 mo17–57 · 223 studies—35 mo17–53 · 205 studies
Observational44 mo17–83 · 185 studies—42 mo17–83 · 178 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting1

Newly registered4

Studies

Recruiting first, then most recently updated. Showing 50 of 991. Browse all 991 → or search them.