Foramen Ovale, Patent clinical trials
The registry lists 136 studies for Foramen Ovale, Patent across more than 10 countries. 47 are recruiting or about to start. 87 of them are mainly about Foramen Ovale, Patent (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Abbott Medical Devices (11) · Lifetech Scientific (Shenzhen) Co., Ltd. (6) · W.L.Gore & Associates (4) · Chinese Academy of Medical Sciences, Fuwai Hospital (4) · Cierra (3) · Assistance Publique - Hôpitaux de Paris (3) · University of Oregon (3) · China National Center for Cardiovascular Diseases (3)
What is being tested here
Drugs under test in Foramen Ovale, Patent studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Aspirin | 0 | 0 | 2 |
| Flecainide | 0 | 1 | 1 |
| Clopidogrel | 0 | 0 | 1 |
| Rivaroxaban | 0 | 0 | 1 |
| Sildenafil | 0 | 0 | 1 |
| Warfarin | 0 | 0 | 1 |
| Apixaban | 0 | 0 | 1 |
Drug classes tested here Factor Xa inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026CeraFlex PFO Closure System PMCF Study · Lifetech Scientific (Shenzhen) Co., Ltd.
- Dec 2026NobleStitch EL STITCH Trial is a PFO Comparative Trial · Nobles Medical Technologies II Inc
- Dec 2026Cerebral Microembolization Associated With PFO Closure · China National Center for Cardiovascular Diseases
- Dec 2026Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale · Peking University Third Hospital
- Jan 2027Non-Invasive Detection of Right-to-Left Cardiac Shunts · Scripps Health
- May 2027Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine · First Affiliated Hospital Xi'an Jiaotong University
- Jun 2027Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke · Josep Rodes-Cabau
- Jun 2027Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale(PREDICT-PFO Trial) · Sichuan University
- Jun 2027Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System · Shanghai Lingsi Medical Technology Co., Ltd.
- Jul 2027Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study · Recross Cardio, Inc.
Who these studies take
Of the 34 Foramen Ovale, Patent studies recruiting now, 11 (32%) set no upper age limit and 19 (56%) stop at 75 or younger. 3 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (6%) | 2 (6%) |
| 18 | 31 (91%) | 31 (91%) |
| 30 | 32 (94%) | 32 (94%) |
| 40 | 32 (94%) | 32 (94%) |
| 50 | 32 (94%) | 32 (94%) |
| 65 | 27 (79%) | 27 (79%) |
| 75 | 15 (44%) | 15 (44%) |
| 85 | 14 (41%) | 14 (41%) |
Across all 136 studies, recruiting or not: 46% stop at 75 or younger and 40% at 65; 16% take children; 0% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Foramen Ovale, Patent studies take
Of 31 interventional studies with no phase under Foramen Ovale, Patent, half reached primary completion within 47 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 47 mo32–100 · 31 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Results posted1
- Long-term Outcomes After Percutaneous Closure of PFOOct 29, 2026NCT05558774
Studies
Recruiting first, then most recently updated. Showing 50 of 136. Browse all 136 → or search them.
- Abbott Structural Heart Device RegistryRecruitingNCT0659046710 countries
- Hummingbird ICE StudyNot yet recruitingNCT075522721 country
- Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic StrokeRecruitingNCT04475510Not applicable1 country
- Migraine Headaches Elimination With Patent Foramen Ovale-Directed TherapyRecruitingNCT07629635Phase 31 country
- Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIARecruitingNCT07380490Not applicable1 country
- Active Surveillance and Safety/Efficacy Evaluation of Innovative Devices for Structural Heart Disease InterventionRecruitingNCT078481521 country
- WSO BEAT STROKE InitiativeNot yet recruitingNCT06606054Not applicable1 country
- Dapagliflozin and Right Heart Recovery After ASD Device ClosureNot yet recruitingNCT07823972Not applicable1 country
- The Cardiovascular Effects of Patent Foramen Ovale in HypoxiaNot yet recruitingNCT07742540
- GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval StudyRecruitingNCT03821129Not applicable1 country
- Safety and Efficacy of the Patent Foramen Ovale Suture System for the Closure of Patent Foramen OvaleNot yet recruitingNCT07726927Not applicable
- Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO StudyRecruitingNCT07172464Not applicable1 country
- Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry)RecruitingNCT077241711 country
- Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS StudyRecruitingNCT07698951Not applicable1 country
- CeraFlex PFO Closure System PMCF StudyRecruitingNCT061202702 countries
- Standardized Goal-Directed vs. Self-Directed Valsalva Maneuver for the Assessment of Patent Foramen OvaleRecruitingNCT06670781Not applicable1 country
- Pulmonary Embolism and Right-to-Left ShuntsRecruitingNCT075198761 country
- Medical Treatment With or Without Transcatheter Patent Foramen Ovale ClosureRecruitingNCT05907694Not applicable1 country
- PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 YearsRecruitingNCT05387954Phase 31 country
- NobleStitch EL STITCH Trial is a PFO Comparative TrialRecruitingNCT04339699Not applicable2 countries
- SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs AnticoagulationRecruitingNCT074791471 country
- Non-Invasive Detection of Right-to-Left Cardiac ShuntsRecruitingNCT074204001 country
- Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound DeviceRecruitingNCT07414446Not applicable1 country
- Neurogenetic And Hemodynamic Of Migraine Aura And PfoRecruitingNCT073490041 country
- Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With MigraineRecruitingNCT07170176Not applicable1 country
- Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder SystemNot yet recruitingNCT07300358Not applicable
- A Comparison of Biodegradable and Metal Occluders in Patients With PFO and MigraineRecruitingNCT06203873Not applicable1 country
- Cerebral Microembolization Associated With PFO ClosureRecruitingNCT063472761 country
- Internal Microstructure of Patent Foramen Ovale Related to StrokeRecruitingNCT046862531 country
- Pioneering Advancements in Cardiocerebrovascular Interactions in the Asia pacFIC - Patent Foramen Ovale StudyNot yet recruitingNCT069837951 country
- Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen OvaleRecruitingNCT069536221 country
- Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale(PREDICT-PFO Trial)RecruitingNCT06863350Not applicable1 country
- Russian Registry of Endovascular Closure of PFORecruitingNCT061566701 country
- Swartz Sheath With Angioplasty Guidewire-Assisted Technique for Patent Foramen Ovale Closure (STAGE-PFO)RecruitingNCT06793969Not applicable1 country
- Encore PFO Closure Device - The PerFOrm TrialRecruitingNCT05537753Not applicable1 country
- Long-term Procedural and Device Related Complications of PFO ClosureNot yet recruitingNCT06413147
- Cardiac Interventional ICE Imaging TrialNot yet recruitingNCT06344494Not applicable1 country
- Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)RecruitingNCT060465081 country
- Does Patent Foramen Ovale Closure Improve Exercise Capacity & Prevent Blood Flow Through Intrapulmonary ShuntEnrolling by invitationNCT03904290Not applicable1 country
- AWARE Registry: Wearable ECG in Structural Heart InterventionsNot yet recruitingNCT062367761 country
- COMPETE Cohort StudyRecruitingNCT060339371 country
- Safety and Efficacy of Cera™ Patent Foramen Ovale Occluders.RecruitingNCT05774288Not applicable1 country
- Patent Foramen Ovale (PFO) and Risk of Perioperative StrokeRecruitingNCT055923011 country
- Study on the Safety and Effectiveness of the SnowyTM PFO Closure SystemNot yet recruitingNCT05360771Not applicable1 country
- COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2)RecruitingNCT05561660Phase 41 country
- Prospective Registry of Elderly ESUS With PFORecruitingNCT052386101 country
- Canadian Adult Congenital Heart Disease Intervention RegistryNot yet recruitingNCT042885961 country
- Efficacy and Safety of PFO Closure vs Medical Therapy in Alleviating MigraineCompletedNCT04946734Phase 31 country
- Philips Intracardiac Echocardiography (ICE) Clinical RegistryCompletedNCT049501921 country
- Long-term Outcomes After Percutaneous Closure of PFOCompletedNCT055587741 country