Heart Diseases clinical trials
The registry lists 2,135 studies for Heart Diseases across more than 10 countries. 252 are recruiting or about to start. 710 of them are mainly about Heart Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 105 narrower conditions too, such as Heart Failure: 29,868 studies, 6,352 open.
ClinicalTrials.gov finds 34,118 studies for Heart Diseases. How that becomes 2,135 here
This page counts the studies the registry files under Heart Diseases, and those it files under no condition that list Heart Diseasesthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 34,118Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −26,161Filed under a narrower condition, counted on its own pageHeart Failure 5,380 · Coronary Artery Disease 4,404 · Atrial Fibrillation 3,495 · Myocardial Infarction 1,344 · Acute Coronary Syndrome 991 · Heart Defects, Congenital 902 · 96 more
- −166List Heart Diseases as a condition, but the registry did not file them under itMost often written as “Congenital Heart Disease in Children” (29), “Hypertensive Heart Disease” (8), and “Complex Congenital Heart Disease” (8). The registry filed 104 of them under no condition at all, and the others under other conditions only, most often Hypertension (7) and Hypertension, Pulmonary (6).
- −5,656Match it another way256 name it in the title, 24 in a keyword, and 5,376 by a synonym or other text the search reads.
- 2,135The count on this page
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Status
Who runs them
National Heart, Lung, and Blood Institute (NHLBI) (455) · University of Minnesota (26) · University of Washington (26) · Mayo Clinic (22) · Duke University (22) · University Health Network, Toronto (18) · University of Pittsburgh (17) · Stanford University (17)
What is being tested here
Drugs under test in Heart Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Colchicine | 4 | 3 | 6 |
| Acoramidis | 2 | 3 | 3 |
| Aspirin | 1 | 5 | 10 |
| Ticagrelor | 1 | 2 | 7 |
| Perflutren | 1 | 4 | 6 |
| Rosuvastatin | 1 | 0 | 4 |
| Heparin | 1 | 2 | 3 |
| Bupivacaine | 1 | 1 | 2 |
| Sulfur Hexafluoride | 1 | 2 | 2 |
| Anti-inhibitor coagulant complex | 1 | 0 | 2 |
Drug classes tested here Beta blockers 2 open · P2Y12 inhibitors 1 open · NSAIDs 1 open · Statins 1 open · Local anesthetics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain · Phase 3 · Rutgers, The State University of New Jersey
- Feb 2027Safety and Efficacy Evaluation of NH002 as a Contrast Agent in Subjects Undergoing Cardiac Echocardiography · Phase 3 · Trust Bio-sonics, Inc.
- Jul 2027A Prospective, Multicenter, Phase III Clinical Evaluation of the Safety and Efficacy of NH002 as a Contrast Agent Administrated Via Intravenous Bolus Injection and Infusion for Subjects Undergoing Cardiac Echocardiography · Phase 3 · Trust Bio-sonics, Inc.
- Sep 2027Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Nov 2026Cooperative Assessment of Late Effects for SCD Curative Therapies · Vanderbilt University Medical Center
- Nov 2026A Study of Electrocardiogram and Focused Cardiac Ultrasound for Enhanced Cardiac Disease Screening · Mayo Clinic
- Nov 2026Danish Randomized Trial on Leadless vs Transvenous Pacing · University of Aarhus
- Nov 2026Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS) · Medtronic Cardiac Ablation Solutions
- Nov 2026Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery · AHEPA University Hospital
- Nov 2026Multidisciplinary Dissection of Renal and Metabolic Effects of Glyfozines on Elderly Patients: From Molecular Aspects to Clinical Indications · Chiara Lanzani
Who these studies take
Of the 180 Heart Diseases studies recruiting now, 128 (71%) set no upper age limit and 21 (12%) stop at 75 or younger. 32 (18%) take children under 18. 7 (4%) are for women only and 0 (0%) for men only; 42 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 27 (15%) | 27 (15%) |
| 18 | 149 (83%) | 145 (81%) |
| 30 | 161 (89%) | 156 (87%) |
| 40 | 162 (90%) | 157 (87%) |
| 50 | 164 (91%) | 160 (89%) |
| 65 | 171 (95%) | 165 (92%) |
| 75 | 165 (92%) | 161 (89%) |
| 85 | 148 (82%) | 145 (81%) |
Across all 2,135 studies, recruiting or not: 21% stop at 75 or younger and 13% at 65; 32% take children; 5% are for women only and 15% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Heart Diseases studies take
Of 32 phase 3 interventional studies under Heart Diseases, half reached primary completion within 37 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 21 mo12–49 · 28 studies | — | — |
| Phase 3 | 37 mo19–58 · 32 studies | — | — |
| Phase 4 | 51 mo28–75 · 24 studies | — | — |
| Interventional, no phase | 25 mo10–52 · 336 studies | 31 mo12–66 · 73 studies | 24 mo10–51 · 263 studies |
| Observational | 45 mo18–95 · 238 studies | 37 mo15–65 · 54 studies | 49 mo22–118 · 184 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Well-being Program for Caregivers of Patients With Advanced Cardiac and Pulmonary DiseaseNov 5, 2026NCT07685912
- First-in-man Trial to Assess the Safety, Performance and Clinical Benefit of the TRICENTO G2 Transcatheter Valve System for Tricuspid RegurgitationOct 23, 2026NCT07536724
- TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)Oct 21, 2026NCT07684313
- INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac RecoveryOct 13, 2026NCT06965504
Results posted2
- A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart SurgeryNov 9, 2026NCT00246779
- ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKEOct 29, 2026NCT05746559
Stopped1
Newly registered3
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesNov 2, 2026NCT07911007
- Reducing Arterial Inflammation Using Eplerenone and Statins in HIVOct 23, 2026NCT07892664
- Replacing Spatial Filtering With Deep-learning Noise ReductionOct 22, 2026NCT07888218
Studies
Recruiting first, then most recently updated. Showing 50 of 2,135. Browse all 2,135 → or search them.
- A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)RecruitingNCT07286578Not applicable4 countries
- Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular GraftsRecruitingNCT04467671Phase 21 country
- NHLBI-Emory Advanced Cardiac CT ReconstructionNot yet recruitingNCT053726271 country
- AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)RecruitingNCT058907162 countries
- Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney TransplantationRecruitingNCT062344101 country
- Well-being Program for Caregivers of Patients With Advanced Cardiac and Pulmonary DiseaseRecruitingNCT07685912Not applicable1 country
- Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart FailureRecruitingNCT06526195Not applicable8 countries
- A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)RecruitingNCT07241390Phase 338 countries
- Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram StudyRecruitingNCT074799921 country
- Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular SystemRecruitingNCT011434541 country
- ELEVATE-HFpEF Clinical StudyRecruitingNCT06678841Not applicable15 countries
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesRecruitingNCT07911007Not applicable1 country
- BoStOn SCientific Rhythm MAnagemenT REgiStryRecruitingNCT0482366310 countries
- Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.RecruitingNCT03242642Not applicable3 countries
- Danish Pragmatic Randomized Trial to Evaluate the Effect of HeartLogic-Guided Management on Heart Failure OutcomesRecruitingNCT06099158Not applicable1 country
- Transition to KPL-387 Monotherapy Dosing & Administration StudyRecruitingNCT07288216Phase 210 countries
- VWCR to Improve Cardiovascular Health and Outcomes Among Cardiac Patients: A Multicenter Randomized Clinical Trial Protocol (Destination Cardiac Rehab Study)Not yet recruitingNCT07745894Not applicable1 country
- Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic HealthRecruitingNCT06587204Not applicable1 country
- Safety and Effectiveness of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere VT)RecruitingNCT07585968Not applicable1 country
- Reducing Arterial Inflammation Using Eplerenone and Statins in HIVNot yet recruitingNCT07892664Phase 2/31 country
- Synchronized Diaphragmatic Stimulation in Symptomatic Heart FailureRecruitingNCT06552637Not applicable2 countries
- First-in-man Trial to Assess the Safety, Performance and Clinical Benefit of the TRICENTO G2 Transcatheter Valve System for Tricuspid RegurgitationRecruitingNCT07536724Not applicable1 country
- Replacing Spatial Filtering With Deep-learning Noise ReductionNot yet recruitingNCT078882181 country
- TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)RecruitingNCT076843131 country
- Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.RecruitingNCT047031661 country
- Lumason® Infusion vs. Bolus AdministrationsRecruitingNCT06400004Phase 31 country
- Clinical Course Of Disease In Participants With FA-CMRecruitingNCT068654828 countries
- BAG3-DCM Natural History StudyNot yet recruitingNCT07486752
- Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)RecruitingNCT050558301 country
- Global Utilization And Registry Database for Improved heArt preservatioNEnrolling by invitationNCT041416054 countries
- Non-Invasive Method for Evaluation of Cardiac Resynchronization TherapyRecruitingNCT058686161 country
- PKP2-ACM Natural History StudyRecruitingNCT066447422 countries
- American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)RecruitingNCT041858441 country
- INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac RecoveryRecruitingNCT06965504Not applicable1 country
- French Observatory on the Management of Cardiogenic Shock 2Not yet recruitingNCT078687571 country
- Technical Development of Cardiovascular Magnetic Resonance ImagingRecruitingNCT049274291 country
- Echocardiography in Nursing HomeRecruitingNCT06445231Not applicable1 country
- Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory FailureRecruitingNCT07157696Not applicable1 country
- New Heart Imaging Techniques to Evaluate Possible Heart DiseaseRecruitingNCT01399385Not applicable1 country
- Evaluation of a Remote Behavioural Stress Recovery Intervention for Myocardial Infarction Patients Younger Than Fifty-five (BRIM-55): A Feasibility StudyRecruitingNCT07706816Not applicable1 country
- COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 DiabetesRecruitingNCT05633810Phase 38 countries
- The CLASP III TR CED StudyNot yet recruitingNCT078597091 country
- Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border RegionsRecruitingNCT06596902Not applicable1 country
- Gauging Outcomes of Total Milk Ingestion on Lipid and gControlRecruitingNCT07087184Not applicable1 country
- A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated CardiomyopathyRecruitingNCT07137338Phase 11 country
- Diagnostic Efficacy of Connected WAtch ECG Versus External Holter ECGRecruitingNCT06420960Not applicable1 country
- Left Bundle Branch Area Pacing (LBBAP) PMCF StudyRecruitingNCT07217392Not applicable9 countries
- The Use of Remimazolam for TEENot yet recruitingNCT07829458Phase 41 country
- Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Prevent Rejection in Heart Transplant ChildrenRecruitingNCT04924491Phase 1/21 country
- Personalized Environment and Genes StudyRecruitingNCT003412371 country