Drug
Simvastatin clinical trials
Also written Zocor, MK 733, MK0733 and Synvinolin.
- studies test it
- 386
- open now
- 27
- in phase 3
- 95
- first study started
- 1991
Keep track of what changes. Save the Simvastatin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
380 studies that test it; most in 2005 (34); 1 more planned to start later
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1993 | 1 |
| 1998 | 2 |
| 1999 | 1 |
| 2000 | 6 |
| 2001 | 1 |
| 2002 | 10 |
| 2003 | 6 |
| 2004 | 12 |
| 2005 | 34 |
| 2006 | 30 |
| 2007 | 30 |
| 2008 | 26 |
| 2009 | 20 |
| 2010 | 27 |
| 2011 | 14 |
| 2012 | 16 |
| 2013 | 14 |
| 2014 | 13 |
| 2015 | 13 |
| 2016 | 12 |
| 2017 | 11 |
| 2018 | 15 |
| 2019 | 9 |
| 2020 | 10 |
| 2021 | 11 |
| 2022 | 10 |
| 2023 | 4 |
| 2024 | 9 |
| 2025 | 5 |
| 2026 | 7 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 13
- Phase 1
- 78
- Phase 2
- 92
- Phase 3
- 95
- Phase 4
- 81
- No phase
- 50
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 111 · Other 275
Organon and Co (27) · Merck Sharp & Dohme LLC (9) · Samsung Medical Center (9) · AstraZeneca (7) · GlaxoSmithKline (7) · Eli Lilly and Company (6) · Pfizer (6) · University of Oxford (4)
Often tested with
Tested in the same studies.
Ezetimibe (45) · Atorvastatin (27) · Rosuvastatin (23) · Metformin (10) · Fenofibrate (9) · Niacin (7) · Pravastatin (7) · Aspirin (7)
Studies
Open first, then newest update. How each study uses Simvastatin is read from its arms, and is right about nine times in ten.
Testing it · 386
- Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory FailureNot yet recruitingPhase 2University of Colorado, DenverNCT07779642Written as Simvastatin
- The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast CancerRecruitingPhase 2Universitas IndonesiaNCT05550415Written as Simvastatin 40mg
- VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingPhase 2Inova Health Care ServicesNCT07831369Written as Simvastatin
- Topical Simvastatin for Treating Infantile HemangiomaNot yet recruitingEarly Phase 1Joyce TengNCT06273111Written as 5% simvastatin ointment
- Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic PancreatitisRecruitingEarly Phase 1Cedars-Sinai Medical CenterNCT05771675Written as Simvastatin
- Endometriosis and Microvascular Dysfunction; Simvastatin and DuaveeEnrolling by invitationPhase 4Penn State UniversityNCT05059626Written as simvastatin 10mg
- Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast CancerRecruitingEarly Phase 1Emory UniversityNCT05464810Written as Simvastatin
- New Topical Treatment in Patchy Alopecia AreataNot yet recruitingNot applicableSohag UniversityNCT07696585Written as Topical Simvastatin 2% ointment
- RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) TrialNot yet recruitingPhase 2McGill University Health Centre/Research Institute of the McGill University Health CentreNCT07625930Written as Simvastatin
- Topical 2% Simvastatin for Xanthelasma PalpebrarumNot yet recruitingPhase 2Klira SkinNCT07662785Written as Topical Simvastatin 2% Cream
- Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma PatientsRecruitingPhase 2National Cancer Institute, NaplesNCT05821556Written as Simvastatin 20mg
- Adebrelimab Combined With Gemcitabine, Cisplatin, and Simvastatin for Advanced Biliary Tract CancerRecruitingPhase 1/2Tongji HospitalNCT07392541Written as Simvastatin 20mg
- T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate CancerRecruitingPhase 2Medical University of South CarolinaNCT05586360Written as Simvastatin 40mg
- Effects of Selected Statins on Blood Glucose Levels in Healthy VolunteersNot yet recruitingPhase 1Shaheed Benazir Bhutto University Sheringal Dir UpperNCT07378293Written as Simvastatin (10mg, 20mg, 40mg)
- Topic Simvastatin for Bone RegenerationRecruitingEarly Phase 1Universidad de GranadaNCT07031778Written as Simvastatin
- Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and SurvivalRecruitingNot applicablePost Graduate Institute of Medical Education and Research, ChandigarhNCT06431919Written as Simvastatin 20mg
- Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract CancerNot yet recruitingPhase 2Tongji HospitalNCT07003815Written as Envafolimab + Gemcitabine + Cisplatin + Simvastatin
- Efficacy of Simvastatin in Alcoholic Liver FibrosisRecruitingPhase 2/3Anna CrucetaNCT04971577Written as Simvastatin 40mg
- Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)RecruitingPhase 3Lund UniversityNCT03131726Written as Simvastatin 40mg
- Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult SubjectsRecruitingPhase 1Modern Biosciences LtdNCT06379958Written as Simvastatin 40mg
See all 386 studies that test Simvastatin →
Given in every arm · 35 — Simvastatin is usual care beside what is tested
- Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise CapacityCompletedNot applicableUniversity of California, San DiegoNCT02490527Written as Simvastatin (40mg)
- A Study of LY3502970 in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT03929744Written as Simvastatin
- KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug MetabolismCompletedNot applicableHelsinki University Central HospitalNCT06566794Written as Simvastatin tablets
- Study To Assess The Efficacy Of A Cholesterol Lowering Drug On Top Of Statins In Patients After Myocardial Infarction (MI)(0653A-150)CompletedPhase 4Organon and CoNCT00652717Written as simvastatin
- Effect Of Ezetimibe Coadministration With Simvastatin In A Middle Eastern Population: A Prospective, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial (0653-151)CompletedPhase 4Organon and CoNCT00652444Written as simvastatin
- Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED)CompletedPhase 3Organon and CoNCT00423488Written as Simvastatin 20 mg
- Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV DiseaseStatus unknownNot applicableCambridge University Hospitals NHS Foundation TrustNCT03355027Written as Simvastatin 80mg
- Effect of Enhanced External Counterpulsation (EECP) on Subclinical AtherosclerosisCompletedNot applicableSun Yat-sen UniversityNCT01106495Written as Simvastatin
- Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid ArthritisCompletedPhase 4King Edward Medical UniversityNCT04177173Written as Simvastatin 20 mg
- A Drug-Drug Interaction Study of Lanabecestat (LY3314814) in Healthy ParticipantsCompletedPhase 1AstraZenecaNCT02406261Written as Simvastatin
- Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With HypercholesterolemiaCompletedPhase 3SanofiNCT02715726Written as simvastatin
- Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir CombinationCompletedPhase 2/3Ain Shams UniversityNCT03490097Written as Simvastatin 10mg
- Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic PeriodontitisCompletedPhase 4Ain Shams UniversityNCT03419429Written as Simvastatin
- 15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects.CompletedPhase 1GlaxoSmithKlineNCT00495729Written as Simvastatin
- A Study of Baricitinib and Simvastatin in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT01960140Written as Simvastatin
- A Study for Pre-diabetic Patients With Cholesterol Lowering DrugsCompletedPhase 2/3University of ChicagoNCT00831129Written as Simvastatin
- Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-beingCompletedPhase 4University of CopenhagenNCT02255682Written as Simvastatin
- Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary SyndromeStatus unknownPhase 4Koval' O., MDNCT02015988Written as Simvastatin
- Niacin Plus Statin to Prevent Vascular EventsTerminatedPhase 3Axio Research. LLCNCT00120289Written as Simvastatin
- The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in AsthmaCompletedPhase 3Mahidol UniversityNCT01266434Written as Simvastatin
Showing 20 of 35.
As the comparator · 25 — what is tested is compared with Simvastatin
- Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on DialysisCompletedPhase 3Tanabe Pharma CorporationNCT00858637Written as Simvastatin
- IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103)CompletedPhase 3Organon and CoNCT00202878Written as simvastatin
- The Effects of Ezetimibe/Simvastatin 10/20 mg Versus Simvastatin 40 mg in High Cholesterol and Coronary Heart Disease Study (P04039AM2)(COMPLETED)CompletedPhase 4Organon and CoNCT00423579Written as simvastatin 40 mg
- Protective Effect of Zingiber Officinale L. Extract in Hypertensive PatientsCompletedEarly Phase 1Jinnah Sindh Medical UniversityNCT05682911Written as Simvastatin 20mg
- Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal TherapyCompletedPhase 4Ain Shams UniversityNCT05657015Written as Simvastatin
- Microcirculation In Acute Coronary SyndromesCompletedPhase 4Helse Stavanger HFNCT01382472Written as Simvastatin
- Efficacy/Safety of Rosuvastatin+Ezetimibe in High Risk Patients With Primary Hypercholesterolemia/Mixed DyslipidemiaCompletedPhase 3Ache Laboratorios Farmaceuticos S.A.NCT01420549Written as Simvastatin 20 mg + Ezetimibe 10 mg and Simvastatin 40 mg + Ezetimibe 10 mg, according to clinical evaluation.
- A Multiple-dose Study of LY3031207 in Healthy ParticipantsTerminatedPhase 1Eli Lilly and CompanyNCT01632566Written as Simvastatin
- Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLDStatus unknownNot applicableThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityNCT03375580Written as Simvastatin
- Donor Simvastatin Treatment in Organ TransplantationCompletedPhase 2/3Helsinki University Central HospitalNCT01160978Written as Simvastatin 80mg
- Acupuncture and Moxibustion for HyperlipemiaStatus unknownNot applicableThe First Affiliated Hospital of Hunan University of Traditional Chinese MedicineNCT02269046Written as Simvastatin
- The Effect of XueZhiKang on Fatigue：Comparing With SimvastatinCompletedPhase 4Wenzhou Medical UniversityNCT01686451Written as simvastatin
- Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL CholesterolTerminatedPhase 2Ferrer Internacional S.A.NCT01362218Written as Simvastatin, ramipril, acetylsalicylic acid
- Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and TriglyceridesCompletedPhase 3AstraZenecaNCT00812955Written as simvastatin
- A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) CholesterolTerminatedPhase 2Ferrer Internacional S.A.NCT01004705Written as Simvastatin
- Efficacy and Safety of Simvast Controlled Release (CR) and Zocor in Chronic Kidney Disease(CKD) Stage 3, 4 and 5 Patients With HyperlipidemiaStatus unknownPhase 4Hanmi Pharmaceutical Company LimitedNCT01564875Written as Zocor
- The Indian POLYCAP Study (TIPS)CompletedNot applicableSt. John's Research InstituteNCT00443794Written as Simvastatin
- Additive Effect of Ezetimibe Upon Simvastatin During Myocardial InfarctionCompletedPhase 4Brasilia Heart Study GroupNCT00905905Written as Simvastatin
- Study to Compare the Efficacy and Safety of Pitavastatin and SimvastatinCompletedPhase 3Kowa Research EuropeNCT00309738Written as simvastatin
- Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk FactorsCompletedPhase 3Kowa Research EuropeNCT00344175Written as simvastatin
Showing 20 of 25.
Codes
What other systems call Simvastatin · ClinicalTrials.gg INT008729
- MeSH (NLM) D019821SimvastatinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) AGG2FN16EVSIMVASTATINConfirmed FDA, NLM, Wikidata
- RxNorm 36567Confirmed FDA, Wikidata
- Wikidata Q670131simvastatinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29454SimvastatinOne source FDA
- DrugBank DB00641One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D019821 | Simvastatin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | AGG2FN16EV | SIMVASTATIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 36567 | — | Confirmed FDA, Wikidata |
| Wikidata | Q670131 | simvastatin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29454 | Simvastatin | One source FDA |
| DrugBank | DB00641 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.