Bicuspid Aortic Valve Disease clinical trials
The registry lists 62 studies for Bicuspid Aortic Valve Disease across more than 10 countries. 21 are recruiting or about to start. 36 of them are mainly about Bicuspid Aortic Valve Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Status
Who runs them
University of Michigan (3) · Cedars-Sinai Medical Center (3) · Solventum US LLC (2) · Boston University (2) · Gruppo di Ricerca GISSI (1) · University of Leicester (1) · Michele De Bonis (1) · Maastricht University Medical Center (1)
What is being tested here
Drugs under test in Bicuspid Aortic Valve Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Atorvastatin | 0 | 1 | 1 |
| Atenolol | 0 | 1 | 1 |
| Telmisartan | 0 | 1 | 1 |
| Losartan | 0 | 0 | 1 |
| Vitamin K 2 | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Cardiac Imaging in Adults With Congenital Aortic Stenosis · Erasmus Medical Center
- Dec 2026Strength Tracking From Wall Tichness Over Aortic Biomechanics (STORM) · IRCCS Policlinico S. Donato
- Dec 2026Valvular Assessment of New Generation Aortic Replacement Devices · Instituto Dante Pazzanese de Cardiologia
- Jun 2027Towards a More Standardized Bicuspid Aortic Valve Repair: Rationale and Design of CONTOUR Trial - a Randomized Trial · University Hospital Augsburg
- Oct 2027Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve · Yonsei University
Who these studies take
Of the 17 Bicuspid Aortic Valve Disease studies recruiting now, 12 (71%) set no upper age limit and 3 (18%) stop at 75 or younger. 5 (29%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (24%) | 4 (24%) |
| 18 | 12 (71%) | 12 (71%) |
| 30 | 14 (82%) | 14 (82%) |
| 40 | 14 (82%) | 14 (82%) |
| 50 | 17 (100%) | 17 (100%) |
| 65 | 16 (94%) | 16 (94%) |
| 75 | 14 (82%) | 14 (82%) |
| 85 | 13 (76%) | 13 (76%) |
Across all 62 studies, recruiting or not: 19% stop at 75 or younger and 13% at 65; 21% take children; 0% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 62. Browse all 62 → or search them.
- Bicuspid Aortic Valve (BAV) RegistryEnrolling by invitationNCT017562221 country
- TAVR vs SAVR in Severe Bicuspid Aortic StenosisRecruitingNCT07413965Not applicable1 country
- Nordic Consortium for Acute Type A Aortic Dissection-2RecruitingNCT068625831 country
- Follow-up of a Cohort of Patients With Aortic Valve BicuspidiaRecruitingNCT031397861 country
- Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From ChinaRecruitingNCT068304991 country
- Cardiovascular Health Improvement ProjectRecruitingNCT023062001 country
- Strength Tracking From Wall Tichness Over Aortic Biomechanics (STORM)RecruitingNCT074532511 country
- Prospective 4D CTA of BAV CompetenceRecruitingNCT046458621 country
- Towards a More Standardized Bicuspid Aortic Valve Repair: Rationale and Design of CONTOUR Trial - a Randomized TrialRecruitingNCT06869954Not applicable1 country
- TAVR vs. SAVR Study of VitaFlow Liberty® for Severe BAV StenosisEnrolling by invitationNCT06597188Not applicable1 country
- Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot TrialRecruitingNCT06817148Not applicable1 country
- Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve ReplacementRecruitingNCT057392531 country
- A Study of Chinese Congenital Bicuspid Aortic ValveRecruitingNCT068020161 country
- Valvular Assessment of New Generation Aortic Replacement DevicesRecruitingNCT06688448Not applicable1 country
- Size Up Bicuspid with the LIra MEthod: the SUBLIME StudyRecruitingNCT066579112 countries
- Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic StenosisEnrolling by invitationNCT062120503 countries
- NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International ExperienceNot yet recruitingNCT063755901 country
- Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic ValveRecruitingNCT061534071 country
- Bicuspid Echocardiac Study Team（BEST）RecruitingNCT056568201 country
- A Multicentre Retrospective Study on Bicuspid Aortic ValveRecruitingNCT058187221 country
- Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement RegistryRecruitingNCT038365211 country
- Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid StudyActive, not recruitingNCT03635424Not applicable1 country
- Aortic Valve-sparing Root Replacement, According to the Inclusion Technique Described by Tirone DavidCompletedNCT055158481 country
- Research on Aneurysm Growth Prediction in Vascular Dilation Caused by Bicuspid Aortic Valve Based on VDM and CFDCompletedNCT077829181 country
- BIVOLUTX: Bicuspid Aortic Stenosis With Evolut Platform International Experience.CompletedNCT034950501 country
- International Bicuspid Aortic Valve Consortium (BAVCon)Active, not recruitingNCT019807975 countries
- Identification of Genetic Causes of Bicuspid Aortic Valve DiseaseActive, not recruitingNCT010265711 country
- Comparison of Rate and Amount of Orthodontic Space ClosureCompletedNCT07445321Not applicable1 country
- In Vivo Pulp Thermal Changes During Different Slenderization TechniquesActive, not recruitingNCT07391124Not applicable1 country
- Pathogenetic Basis of Aortopathy and Aortic Valve DiseaseActive, not recruitingNCT034406971 country
- Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar SitesCompletedNCT03570333Not applicable1 country
- Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)CompletedNCT05711693Not applicable1 country
- Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal ImagingCompletedNCT03474159Not applicable1 country
- The CASPER RegistryCompletedNCT04817735Not applicable1 country
- Comparative Assessment of Mental/Incisive and Inferior Alveolar Nerve Block Anesthesia in Root Canal Treatment of Mandibular PremolarsCompletedNCT06679660Not applicable1 country
- Clinical Study on a New Flowable Composite as a Restorative in Adult TeethCompletedNCT01369108Not applicable1 country
- Clinical Performance of Incremental and Bulk Fill Composites in Class II RestorationsCompletedNCT02889835Not applicable1 country
- Proximal Aortopathy in Scotland - Epidemiology and Surgical OutcomesActive, not recruitingNCT053898651 country
- Cardiac Imaging in Adults With Congenital Aortic StenosisActive, not recruitingNCT052523511 country
- Role of Elastin Metabolites in Aortic Remodelling in ASCompletedNCT038834901 country
- Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium FluorideCompletedNCT040831181 country
- Fate at Long-term of Mild to Moderate Bicuspid Aortic Valve Disease Left Untreated at the Time of Supracoronary Ascending Aorta ReplacementCompletedNCT058363631 country
- Clinical and Dimensional Outcomes of Sealing Socket Abutment Combined to Alveolar Ridge PreservationActive, not recruitingNCT04553146Phase 41 country
- Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement.Status unknownNCT057081181 country
- Aortic Valve Dynamics During Exercise After Valve Sparing Root Replacement SurgeryCompletedNCT04205474Not applicable1 country
- Genetic Risks for Bicuspid Aortic Valve DiseaseCompletedNCT018234321 country
- Tissue-resident Memory T Cells Expression Among the Repigmentation Patterns Induced by NB-UVB Phototherapy in VitiligoCompletedNCT055069951 country
- Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve DiseaseCompletedNCT028063101 country
- Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic ValveCompletedNCT02679261Phase 31 country
- The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement RegistryCompletedNCT023941841 country