Hypoplastic Left Heart Syndrome clinical trials
The registry lists 67 studies for Hypoplastic Left Heart Syndrome across more than 10 countries. 12 are recruiting or about to start. 51 of them are mainly about Hypoplastic Left Heart Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
University of Michigan (5) · Emory University (5) · Timothy J Nelson, MD, PhD (4) · University of Alberta (3) · Children's Hospital of Philadelphia (3) · University of California, San Francisco (3) · The Hospital for Sick Children (3) · Medical College of Wisconsin (3)
What is being tested here
Drugs under test in Hypoplastic Left Heart Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sildenafil | 0 | 0 | 2 |
| Dexmedetomidine | 0 | 0 | 2 |
| Cell Types | 0 | 0 | 1 |
| Oxygen | 0 | 0 | 1 |
| Epoetin Alfa | 0 | 0 | 1 |
| Ambrisentan | 0 | 0 | 1 |
| Ascorbic Acid | 0 | 0 | 1 |
| Triiodothyronine | 0 | 1 | 1 |
| Bosentan | 0 | 0 | 1 |
| Oxandrolone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
Who these studies take
Of the 9 Hypoplastic Left Heart Syndrome studies recruiting now, 3 (33%) set no upper age limit and 6 (67%) stop at 75 or younger. 9 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (44%) | 4 (44%) |
| 18 | 4 (44%) | 4 (44%) |
| 30 | 4 (44%) | 4 (44%) |
| 40 | 4 (44%) | 4 (44%) |
| 50 | 4 (44%) | 4 (44%) |
| 65 | 3 (33%) | 3 (33%) |
| 75 | 3 (33%) | 3 (33%) |
| 85 | 3 (33%) | 3 (33%) |
Across all 67 studies, recruiting or not: 79% stop at 75 or younger and 79% at 65; 94% take children; 9% are for women only and 0% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 67. Browse all 67 → or search them.
- Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular GraftsRecruitingNCT04467671Phase 21 country
- Long-term Safety Study Following to JRM-001 Treatment in Pediatric Patients With Congenital Heart DiseaseRecruitingNCT078843181 country
- Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)RecruitingNCT02781922Phase 31 country
- Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart DiseaseRecruitingNCT067116661 country
- Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart SyndromeEnrolling by invitationNCT06342999Not applicable1 country
- The Co-Op @ HeartWorksRecruitingNCT064699181 country
- Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical PatchNot yet recruitingNCT06853054Not applicable1 country
- National Collaborative to Improve Care of Children With Complex Congenital Heart DiseaseRecruitingNCT028520313 countries
- NIRS in Congenital Heart Defects - Correlation With EchocardiographyRecruitingNCT041064791 country
- Effect of Fetal Aortic Valvuloplasty on OutcomesRecruitingNCT053861738 countries
- Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS)Not yet recruitingNCT06461676Phase 11 country
- An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart DiseaseRecruitingNCT067680081 country
- Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart DiseaseCompletedNCT04581668Not applicable1 country
- The CHILD Trial: Hypoplastic Left Heart Syndrome Study.CompletedNCT03406884Phase 11 country
- 3D Modalities for Medical Student Education of Congenital Heart DiseaseCompletedNCT07295730Not applicable1 country
- Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart SyndromeActive, not recruitingNCT03779711Phase 21 country
- Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHDActive, not recruitingNCT04907526Phase 11 country
- Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial.Active, not recruitingNCT04925024Phase 21 country
- Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome PatientsCompletedNCT01856049Not applicable1 country
- Cerebral Anatomy, Hemodynamics and MetabolismCompletedNCT029199561 country
- Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood PalliationTerminatedNCT057092751 country
- Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCTActive, not recruitingNCT04702373Phase 32 countries
- Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative PeriodCompletedNCT04452188Not applicable1 country
- Use of Oxandrolone to Promote Growth in Infants With HLHSTerminatedNCT04090697Phase 1/22 countries
- Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart SyndromeTerminatedNCT01445041Phase 11 country
- Maternal Hyperoxygenation in Congenital Heart DiseaseCompletedNCT03136835Phase 1/21 country
- Cold Heart Study: A Randomized Pilot Trial of Surfactant TherapyTerminatedNCT04181255Phase 11 country
- Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left VentricleStatus unknownNCT03079401Phase 1/21 country
- Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart SyndromeCompletedNCT01736956Not applicable1 country
- Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike)CompletedNCT04056416Not applicable1 country
- Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart SurgeryCompletedNCT03431480Phase 11 country
- Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart SyndromeCompletedNCT01883076Phase 11 country
- Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS)CompletedNCT01829750Phase 21 country
- Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle PhysiologyCompletedNCT01273857Phase 11 country
- Genetic Determinants of Congenital Heart Disease OutcomesCompletedNCT016569412 countries
- Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart SyndromeTerminatedNCT02398604Phase 11 country
- A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical PalliationCompletedNCT017088631 country
- Cardiac Biomarkers in Patients With Single Ventricle PhysiologyCompletedNCT036789091 country
- Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)CompletedNCT02184169Not applicable1 country
- Initiation of Resuscitation While Attached to the Cord With Congenital Heart DiseaseWithdrawnNCT03690245Not applicable1 country
- Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryCompletedNCT00513240Phase 1/21 country
- Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a NewbornCompletedNCT007346431 country
- SVRII Family Factors StudyCompletedNCT015825292 countries
- Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI TechniquesTerminatedNCT011079901 country
- Ambrisentan in Single VentricleCompletedNCT02080637Phase 21 country
- Near-infrared Spectroscopy (NIRS) Neurodevelopmental OutcomesCompletedNCT004641001 country
- Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood ProcedureCompletedNCT01215240Not applicable1 country
- Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart DiseaseStatus unknownNCT03147014Not applicable1 country
- Positive Pressure Ventilation and Sternal Closure in HLHSWithdrawnNCT024557131 country
- Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical ReconstructionCompletedNCT021350811 country