Ductus Arteriosus, Patent clinical trials
The registry lists 146 studies for Ductus Arteriosus, Patent across more than 10 countries. 21 are recruiting or about to start. 116 of them are mainly about Ductus Arteriosus, Patent (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-07.
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Who runs them
Shaare Zedek Medical Center (8) · Zekai Tahir Burak Women's Health Research and Education Hospital (5) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (5) · Abbott Medical Devices (4) · University of Florida (4) · Assiut University (4) · Albany Medical College (4) · University of Utah (3)
What is being tested here
Drugs under test in Ductus Arteriosus, Patent studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Acetaminophen | 4 | 6 | 23 |
| Ibuprofen | 1 | 4 | 25 |
| Indomethacin | 0 | 3 | 9 |
| Solufenum | 0 | 1 | 2 |
| Thiamine | 0 | 0 | 1 |
| Fenoldopam | 0 | 1 | 1 |
| Poractant alfa | 0 | 0 | 1 |
| Glucose | 0 | 0 | 1 |
| Pentoxifylline | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Nov 2026PREEMIE: Study for Treatment of PDA in Premature Infants · Merit Medical Systems, Inc.
- Dec 2026Long Term Follow-up of the TREOCAPA Study (TREOCAPA-LT) · Institut National de la Santé Et de la Recherche Médicale, France
- Dec 2026HeartR™ PDA Occluder Post-Market Follow-Up Study · Lifetech Scientific (Shenzhen) Co., Ltd.
- Jan 2027Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants · Mount Sinai Hospital, Canada
Who these studies take
Of the 14 Ductus Arteriosus, Patent studies recruiting now, 4 (29%) set no upper age limit and 10 (71%) stop at 75 or younger. 14 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (29%) | 4 (29%) |
| 18 | 4 (29%) | 4 (29%) |
| 30 | 4 (29%) | 4 (29%) |
| 40 | 4 (29%) | 4 (29%) |
| 50 | 4 (29%) | 4 (29%) |
| 65 | 4 (29%) | 4 (29%) |
| 75 | 4 (29%) | 4 (29%) |
| 85 | 4 (29%) | 4 (29%) |
Across all 146 studies, recruiting or not: 86% stop at 75 or younger and 85% at 65; 99% take children; 1% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ductus Arteriosus, Patent studies take
Of 22 observational studies under Ductus Arteriosus, Patent, half reached primary completion within 48 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 48 mo26–65 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 146. Browse all 146 → or search them.
- Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature InfantsRecruitingNCT05340582Phase 24 countries
- Radiological Markers for PDA Management in Preterm InfantsNot yet recruitingNCT07812064Not applicable
- Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus DefectsRecruitingNCT052647539 countries
- HeartR™ PDA Occluder Post-Market Follow-Up StudyRecruitingNCT076467041 country
- NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation PilotRecruitingNCT066462501 country
- Long Term Follow-up of the TREOCAPA Study (TREOCAPA-LT)RecruitingNCT060648251 country
- Research on the Individualized Treatment Strategy for Extremely Preterm Infants With hsPDA Based on Biomarkers and Targeted Delivery SystemsNot yet recruitingNCT07374146
- Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm NeonatesRecruitingNCT073383701 country
- Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCTRecruitingNCT07143201Phase 21 country
- Postnatal Steroids Effects on Cardiac Function in Extremely PretermRecruitingNCT046440941 country
- Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight InfantsRecruitingNCT05547165Not applicable1 country
- Outcome of Transcatheter Closure of Patent Ductus Arteriosus in Pediatric Cardiology Unit in 3 Years DurationNot yet recruitingNCT06634407Not applicable
- Study of Thoracic Ultrasound As a Response to the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature InfantsRecruitingNCT066273741 country
- Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCTRecruitingNCT05011149Phase 32 countries
- Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in NeonatesNot yet recruitingNCT06256211Phase 1/2
- PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation.RecruitingNCT05325177Phase 41 country
- Betamethasone and Closure of Ductus ArteriosusRecruitingNCT059872021 country
- Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus ArteriosusNot yet recruitingNCT06152796Phase 2
- PAIR (Paracetamol and Ibuprofen Research) Pilot TrialRecruitingNCT04986839Phase 2/31 country
- PUFAs in Preterm InfantsNot yet recruitingNCT06045130
- The U.S. PDA RegistryNot yet recruitingNCT042058771 country
- PREEMIE: Study for Treatment of PDA in Premature InfantsActive, not recruitingNCT06587282Not applicable1 country
- Amplatzer Piccolo Occluder Japan Post-marketing Database SurveillanceActive, not recruitingNCT043710811 country
- PDA for Kidneys StudyActive, not recruitingNCT066584961 country
- Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)CompletedNCT01630278Phase 31 country
- Management of the PDA TrialActive, not recruitingNCT03456336Phase 31 country
- Improving Care for Children With Congenital Heart Disease.CompletedNCT04667455Not applicable1 country
- Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus ArteriosusTerminatedNCT03701074Phase 21 country
- Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective CohortCompletedNCT075337211 country
- Prophylactic IV Paracetamol in Extremely Premature InfantsCompletedNCT07067177Phase 2/31 country
- The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart DiseaseCompletedNCT06298344Early Phase 11 country
- Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by AcetaminophenCompletedNCT04459117Phase 2/312 countries
- Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated OutcomesActive, not recruitingNCT037826101 country
- Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus ArteriosusCompletedNCT04037514Phase 31 country
- Liver Regional Oxygen Saturation in Preterm Patent Ductus ArteriosusCompletedNCT056393091 country
- Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational StudyActive, not recruitingNCT069501641 country
- AMPLATZER Duct Occluder II Additional SizesCompletedNCT03055858Not applicable1 country
- Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus ArteriosusTerminatedNCT03648437Phase 11 country
- The Preterm Infants' Paracetamol StudyCompletedNCT01938261Phase 21 country
- Noninvasive Hemodynamics Assessment of Preterms With Successful Medical Closure of PDACompletedNCT066060151 country
- The Effectiveness of Paracetamol Versus Ibuprofen in Management of Patent Ductus Arteriosus in Preterm NeonatesActive, not recruitingNCT06601114Not applicable1 country
- Canadian National PDA Treatment StudyCompletedNCT043477201 country
- Extremely Low Gestatonal Age Infants' Paracetamol StudyCompletedNCT03641209Phase 1/21 country
- Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus ArteriosusCompletedNCT01479218Not applicable2 countries
- Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight InfantsTerminatedNCT03982342Not applicable1 country
- Radiation-Free Heart Catheterization Using MRIActive, not recruitingNCT02739087Not applicable1 country
- The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Preterm BirthWithdrawnNCT03073512Not applicable1 country
- Early Treatment Versus Expectative Management of PDA in Preterm InfantsCompletedNCT02884219Not applicable2 countries
- Closure Of Patent Ductus Arteriosus With the AMPLATZER Duct Occluder the AMPLATZER® Duct OccluderCompletedNCT00583596Not applicable1 country
- Effect of Umbilical Cord Milking Versus Clamping in Preterms on Cerebral Oxygenation and Ductus Arteriosus ClosureCompletedNCT05922488Not applicable1 country