Boston Children's Hospital: Heart Defects, Congenital trials

The registry lists 37 Heart Defects, Congenital studies with Boston Children's Hospital as lead sponsor. 9 are open to participants now and 3 have results posted.

Phase 1 1Phase 2 2Phase 3 2Phase 4 1No phase 33(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Observational Data Collection for Blood Hemoglobin Algorithm Validation in PediatricsNot yet recruitingNCT07706140
• Using Near-Infrared Spectroscopy Devices to Assess Myocardial and Visceral Perfusion During Complex Congenital Cardiac SurgeryNot yet recruitingNCT07361523
• The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac SurgeryNot yet recruitingNCT06899971
• Precision Medicine in the CICU: Identifying Proteomic BiomarkersEnrolling by invitationNCT06642662
• Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal ThrombosisRecruitingNCT06434207
• Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in ChildrenRecruitingNCT05687292
• The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD AdultsRecruitingNCT05258981Not applicable
• Muscle Catabolism and Outcomes in Children Following Cardiac SurgeryRecruitingNCT04998643
• Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac SurgeryRecruitingNCT04299828
• Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle TrainingCompletedNCT01977222Not applicableResults posted
• SPECS: Safe Pediatric Euglycemia in Cardiac SurgeryCompletedNCT00443599Not applicableResults posted
• Nesiritide Use Following Cardiac Surgery in InfantsTerminatedNCT00281671Phase 1/2Results posted
• Empiric Pulsed Field Pulmonary Vein Isolation During Atrial Tachycardia Ablation in Adults With Congenital Heart DiseaseWithdrawnNCT06969378Not applicable
• Atrial Late Gadolinium Enhancement in Patients With Repaired Congenital Heart DiseaseActive, not recruitingNCT05241418
• Enhanced External Counterpulsation in Patients With Fontan CirculationCompletedNCT04956952Not applicable
• Predicting Arrhythmogenic Risk in Congenital Heart Patients: the PRECISION StudyTerminatedNCT04768634Not applicable
• Use of a Predictive Analytics Algorithm to Optimize Weaning of Inotropes Following Pediatric Cardiac SurgeryStatus unknownNCT04600700
• The Use of Music for Neonates Post-Cardiac SurgeryCompletedNCT03925584Not applicable
• The Relationship Between Having a Positive Mindset and Exercise Capacity in Patients With Congenital Heart DiseaseCompletedNCT03912025
• Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart DiseaseCompletedNCT03667703Phase 4
• 3D Cine Cardiovascular Magnetic ResonanceCompletedNCT03583775
• Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary BypassTerminatedNCT03576534Not applicable
• Clinical Characteristics and Associations of the "Good Fontan" PatientCompletedNCT03470428
• Validation of a Novel Oxygen Consumption Measurement Technique in NeonatesCompletedNCT03154112
• Fontan Imaging Biomarkers (FIB) StudyCompletedNCT03119090
• The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart DiseaseCompletedNCT03073122
• Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention StudyCompletedNCT03023644Not applicable
• Preserved Umbilical Vein Use as Autologous Shunt Conduits in Neonatal Cardiac SurgeryCompletedNCT02766998Not applicable
• Improving Neurodevelopment in Adolescents With Congenital Heart DiseaseCompletedNCT02759263Not applicable
• Evaluation of Coagulation Testing in Patients Undergoing Cardiac SurgeryCompletedNCT02410473
• Determination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated FibrinolysisCompletedNCT02352675
• Peri-operative Assessment of Coagulopathy in Neonates and Infants Undergoing Cardiac SurgeryWithdrawnNCT02352662
• Cardiopulmonary Rehabilitation for Adolescents and Adults With Congenital Heart DiseaseCompletedNCT01822769Not applicable
• Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary BypassCompletedNCT01045356
• Cylexin for Reduction of Reperfusion Injury in Infant Heart SurgeryCompletedNCT00226369Phase 2/3
• Trial of Cardiac Magnetic Resonance Imaging (MRI) Versus Cardiac Catheterization Prior to Glenn OperationCompletedNCT00112424Not applicable
• Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3