Drug
Modafinil clinical trials
Also written Provigil, Nuvigil and CEP-10953.
- studies test it
- 187
- open now
- 10
- in phase 3
- 48
- first study started
- 1997
Keep track of what changes. Save the Modafinil studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Studies by the year they started
186 studies that test it; most in 2006 (16)
| Year | Studies |
|---|---|
| 1997 | 1 |
| 2001 | 1 |
| 2002 | 6 |
| 2003 | 13 |
| 2004 | 15 |
| 2005 | 14 |
| 2006 | 16 |
| 2007 | 10 |
| 2008 | 15 |
| 2009 | 15 |
| 2010 | 15 |
| 2011 | 15 |
| 2012 | 4 |
| 2013 | 7 |
| 2014 | 7 |
| 2016 | 3 |
| 2017 | 4 |
| 2018 | 7 |
| 2019 | 1 |
| 2022 | 1 |
| 2023 | 3 |
| 2024 | 4 |
| 2025 | 3 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 30
- Phase 2
- 64
- Phase 3
- 48
- Phase 4
- 29
- No phase
- 26
What it is tested for
Each study’s main condition, where its own words name it.
- Fatigue
- 12
Who runs them
Industry 41 · Other 146
Cephalon (27) · M.D. Anderson Cancer Center (7) · University of Arkansas (5) · Duke University (4) · The University of Texas Health Science Center, Houston (4) · New York State Psychiatric Institute (4) · National Institute on Drug Abuse (NIDA) (4) · Yale University (3)
Often tested with
Tested in the same studies.
Methylphenidate (10) · Minocycline (4) · Propranolol (3) · Caffeine (3) · Acetazolamide (2) · Atomoxetine (2) · Indomethacin (2) · Melatonin (2)
Studies
Open first, then newest update. How each study uses Modafinil is read from its arms, and is right about nine times in ten.
Testing it · 187
- Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived PersonnelRecruitingPhase 4United States Army Research Institute of Environmental MedicineNCT07830056Written as Modafinil (M)
- Modafinil for Debilitating Fatigue in Quiescent Inflammatory Bowel Disease MODIFI-IBD Trial)RecruitingPhase 2/3Radboud University Medical CenterNCT07582458Written as Modafinil
- Modafinil to Improve FatiguabilityRecruitingPhase 1/2Ottawa Hospital Research InstituteNCT05333250Written as Modafinil
- Cognitive Strategies in Early Psychosis 2RecruitingPhase 3University of MinnesotaNCT07263022Written as Modafinil
- Investigation of Locus Coeruleus Function in Sustained AttentionRecruitingPhase 4University of California, DavisNCT06041048Written as Modafinil
- Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNot applicableEnhanced Emirates LimitedNCT07568574Written as Modafinil
- Cognitive Strategies in Early Psychosis 1RecruitingPhase 3University of MinnesotaNCT07231497Written as Modafinil
- Modafinil For Fatigue in IBD: A Feasibility Randomised Controlled TrialNot yet recruitingPhase 2Imperial College LondonNCT07295834Written as Modafinil
- Modafinil and Exercise for Post Stroke FatigueNot yet recruitingPhase 3University Health Network, TorontoNCT06354985Written as Modafinil 200mg
- Central Nervous System Stimulants and Physical Function in Children With Cerebral PalsyNot yet recruitingEarly Phase 1Kuwait UniversityNCT05675098Written as Modafinil
- Treatment of Orthostatic IntoleranceActive, not recruitingPhase 1/2Satish R. RajNCT00262470Written as Modafinil
- Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily ActivityCompletedPhase 1Abdulraheem Mohamed GoudaNCT07852130Written as Modafinil
- RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)CompletedPhase 2Duke UniversityNCT06404099Written as Modafinil
- Method of Assessment of Driving Ability in Patients Suffering From Wakefulness PathologiesCompletedNot applicableUniversity Hospital, BordeauxNCT00916253Written as Modafinil
- RECOVER-SLEEP: Platform ProtocolCompletedPhase 2Duke UniversityNCT06404086Written as Modafinil
- Modafinil and Cognitive Function in POTSActive, not recruitingEarly Phase 1Vanderbilt University Medical CenterNCT01988883Written as Modafinil
- Study Effects of Preoperative Modafinil on Recovery Profile of Morbidly Obese Patients Scheduled for Bariatric Surgery if it Can Enhance Recovery From AnesthesiaCompletedNot applicableAin Shams UniversityNCT07128719Written as Modafinil
- Effects of Armodafinil on Cognition for Patients With Schizophrenia or Schizoaffective DisorderCompletedPhase 4Northwestern UniversityNCT00373672Written as armodafinil (Nuvigil)
- Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade GliomaCompletedPhase 3Alliance for Clinical Trials in OncologyNCT01781468Written as armodafinil 150 mg
- A Clinical Study of MK-6552 and Modafinil in Healthy Men (MK-6552-005)CompletedPhase 1Merck Sharp & Dohme LLCNCT06665230Written as Modafinil
See all 187 studies that test Modafinil →
Given in every arm · 6 — Modafinil is usual care beside what is tested
- Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid TumorsCompletedPhase 1PfizerNCT03864042Written as modafinil
- Complementary Combination Therapy for Cocaine DependenceCompletedPhase 1Baylor College of MedicineNCT02538744Written as Modafinil
- Pharmacodynamics and Efficacy of MK-7288 in Adults With Sleep Apnea (MK-7288-010)CompletedPhase 1Merck Sharp & Dohme LLCNCT01092780Written as Modafinil
- Treatment of Refractory Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) Using Nasal Continuous Positive Airway Pressure (nCPAP) Therapy (0249-015)TerminatedPhase 2Merck Sharp & Dohme LLCNCT00620659Written as Comparator: modafinil
- Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy SubjectsCompletedPhase 1Teva Branded Pharmaceutical Products R&D, Inc.NCT01903824Written as modafinil
- Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea PatientsCompletedPhase 4Jazz PharmaceuticalsNCT00086281Written as Modafinil (M)
As the comparator · 6 — what is tested is compared with Modafinil
- Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic HypersomniaCompletedPhase 2Emory UniversityNCT03772314Written as Modafinil
- Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep LossCompletedPhase 2ShireNCT01096680Written as Armodafinil
- Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep DeprivationCompletedPhase 1TheranexusNCT03182413Written as Modafinil
- A Study of LY3154207 on Sleep in Healthy Male ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT02603861Written as Modafinil
- A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With NarcolepsyCompletedPhase 2Alza Corporation, DE, USANCT00424931Written as Modafinil
- Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in NarcolepsyCompletedPhase 3BioprojetNCT01067222Written as Modafinil
Codes
What other systems call Modafinil · ClinicalTrials.gg INT006717
- MeSH (NLM) D000077408ModafinilConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) R3UK8X3U3DMODAFINILConfirmed FDA, NLM, Wikidata
- RxNorm 30125Confirmed FDA, Wikidata
- Wikidata Q410441modafinilConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C26661ModafinilOne source FDA
- DrugBank DB00745One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077408 | Modafinil | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | R3UK8X3U3D | MODAFINIL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 30125 | — | Confirmed FDA, Wikidata |
| Wikidata | Q410441 | modafinil | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C26661 | Modafinil | One source FDA |
| DrugBank | DB00745 | — | One source Wikidata |
Also registered as armodafinil (UNII V63XWA605I · RxNorm 641465).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.