Sleep Deprivation clinical trials
The registry lists 314 studies for Sleep Deprivation across more than 10 countries. 59 are recruiting or about to start. 204 of them are mainly about Sleep Deprivation (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Brigham and Women's Hospital (8) · University of Utah (5) · Children's Hospital of Philadelphia (5) · Institut de Recherche Biomedicale des Armees (5) · University of Arizona (5) · Uppsala University (5) · Beth Israel Deaconess Medical Center (5) · University of Pittsburgh (5)
What is being tested here
Drugs under test in Sleep Deprivation studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Melatonin | 1 | 1 | 2 |
| Caffeine | 1 | 0 | 2 |
| Propofol | 1 | 0 | 2 |
| Esketamine | 1 | 0 | 1 |
| Modafinil | 0 | 0 | 4 |
| Dexmedetomidine | 0 | 2 | 3 |
| Zolpidem | 0 | 0 | 3 |
| Donepezil | 0 | 0 | 2 |
| Ramelteon | 0 | 0 | 2 |
| 3-Hydroxybutyric Acid | 0 | 0 | 1 |
Drug classes tested here Stimulants 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Sleep Promotion and Pediatric Hypertension · Children's Hospital of Philadelphia
- Dec 2026Effects of Partial Sleep Deprivation on Cardiac Output During Cycling · University of Guelph
- Jan 2027Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities. · Brigham and Women's Hospital
- Apr 2027The Effect of Sleep Loss on Emotion Regulation · Beth Israel Deaconess Medical Center
- May 2027Evolution of Sleep in Intensive Care Unit Patients · Centre Hospitalier Universitaire de Saint Etienne
- Jun 2027The Neurocognitive Effects of Total and Partial Sleep Deprivation in Younger Adults. · Örebro University, Sweden
- Jun 2027Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children · Children's Hospital of Philadelphia
- Jun 2027Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep · U.S. Army Medical Research and Development Command
- Jun 2027Sleep and Circadian Rhythm Intervention in ICU · Shanghai Zhongshan Hospital
- Jun 2027Sleep and Metabolism · Oregon Health and Science University
Who these studies take
Of the 43 Sleep Deprivation studies recruiting now, 11 (26%) set no upper age limit and 28 (65%) stop at 75 or younger. 5 (12%) take children under 18. 3 (7%) are for women only and 0 (0%) for men only; 29 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (2%) | 1 (2%) |
| 18 | 38 (88%) | 35 (81%) |
| 30 | 38 (88%) | 35 (81%) |
| 40 | 33 (77%) | 31 (72%) |
| 50 | 24 (56%) | 23 (53%) |
| 65 | 17 (40%) | 16 (37%) |
| 75 | 15 (35%) | 15 (35%) |
| 85 | 13 (30%) | 13 (30%) |
Across all 314 studies, recruiting or not: 65% stop at 75 or younger and 61% at 65; 16% take children; 4% are for women only and 11% for men only; 66% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sleep Deprivation studies take
Of 150 interventional studies with no phase under Sleep Deprivation, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo7–37 · 150 studies | — | 18 mo8–44 · 141 studies |
| Observational | 19 mo4–58 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 314. Browse all 314 → or search them.
- Investigation of the Effects of Sleep Deprivation on Itch and Pain SensitivityRecruitingNCT06081998Not applicable1 country
- Neurobehavioral Changes Following Spaceflight StressorsRecruitingNCT07293494Not applicable1 country
- The Function of Biphasic Sleep in InfantsRecruitingNCT06399939Not applicable1 country
- Study on the Mechanism of Central Obesity Induced by Sleep Restriction and the Therapeutic Effect of n-3 Polyunsaturated Fatty Acid: a Randomized, Double-blind, Placebo-controlled Trial (COSPA Study)Not yet recruitingNCT07897097Not applicable
- Sleep and Circadian Rhythm Intervention in ICURecruitingNCT07869901Not applicable1 country
- Evolution of Sleep in Intensive Care Unit PatientsNot yet recruitingNCT07867912Not applicable1 country
- Effect of Sleep Extension in Prevention to Sleep DeprivationRecruitingNCT06928168Not applicable1 country
- Mind After MidnightRecruitingNCT07438912Not applicable1 country
- Study of Single Doses of HBS-104 in Acutely Sleep-deprived Healthy ParticipantsRecruitingNCT07848659Phase 11 country
- Sleep Harmonization Via Bundled Team-Based Interventions in the ICUNot yet recruitingNCT07840560Not applicable2 countries
- Acupuncture for Sleep Fragmentation in Older Adults: A Single-Arm Pilot StudyNot yet recruitingNCT07841938Not applicable1 country
- The Neurocognitive Effects of Total and Partial Sleep Deprivation in Younger Adults.Not yet recruitingNCT07822009Not applicable1 country
- Sleep Promotion Program Primary CareRecruitingNCT06240325Not applicable1 country
- Sleep Promotion and Pediatric HypertensionRecruitingNCT06642246Not applicable1 country
- Effect of Sleep Extension on Ceramides in People With Overweight and ObesityRecruitingNCT06180837Not applicable1 country
- Evaluating Worksite Sleep Health Coaching in Firefighters: The Sleep Assistance for Firefighters StudyEnrolling by invitationNCT06684444Phase 41 country
- Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.RecruitingNCT06075914Not applicable1 country
- Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in ChildrenRecruitingNCT05703347Not applicable1 country
- TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTSEnrolling by invitationNCT07434921Not applicable1 country
- Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep ChronobundleRecruitingNCT05551325Not applicable1 country
- Effects of Partial Sleep Deprivation on Cardiac Output During CyclingRecruitingNCT06679543Not applicable1 country
- Restorative Effects of Sleep on Everyday Health and Wellbeing: A Treatment StudyRecruitingNCT07156383Not applicable1 country
- The Effect of Sleep Loss on Emotion RegulationRecruitingNCT05393830Not applicable1 country
- Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating PeriodRecruitingNCT06070194Not applicable1 country
- Nighttime Synchrony of Your Nutrition and Circadian HealthRecruitingNCT07329283Not applicable1 country
- Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults With Sleep Deprivation: A Proof-of-Concept StudyRecruitingNCT07084701Not applicable1 country
- Effects of Acute Sleep Deprivation on Individuals With Different APOE GenotypesRecruitingNCT07085754Not applicable1 country
- Circadian Rhythms and Time Perception in Healthy Adults During Constant WakefulnessRecruitingNCT07294781Not applicable1 country
- Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep CurtailmentNot yet recruitingNCT06809023Not applicable1 country
- Immune Status After Being on Call for 24 HrsRecruitingNCT066363181 country
- Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.RecruitingNCT05835973Not applicable1 country
- Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)RecruitingNCT05588934Not applicable1 country
- Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.Enrolling by invitationNCT063365251 country
- Improving Sleep Quality During Pregnancy Using an Oral ApplianceRecruitingNCT03646214Not applicable1 country
- Shift Hours' Impact on Fatigue and Tracking of Eye DynamicsNot yet recruitingNCT07192380Not applicable1 country
- The Peripheral Blood Multi-Omics Study on Sleep LossRecruitingNCT06492109Not applicable1 country
- Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)RecruitingNCT05070013Not applicable1 country
- Non-invasive Nerve Stimulation for PTSD and SleepRecruitingNCT03170440Not applicable1 country
- Impact of Sleep Deprivation on Malnutrition in ICU (Intensive Care Unit) PatientsNot yet recruitingNCT07032441
- Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM SleepRecruitingNCT02945501Not applicable1 country
- Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic InsomniaNot yet recruitingNCT06644573Phase 11 country
- MONITORING OF ATTENTION ACCORDING TO FATIGUE IN THE HEALTHY SUBJECTRecruitingNCT05531734Not applicable1 country
- Apnea, Stroke and Incident Cardiovascular EventsRecruitingNCT043992001 country
- The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care WorkersRecruitingNCT06737055Not applicable1 country
- The Effects of Night Shift Work on Health Across the Menstrual CycleRecruitingNCT06683248Not applicable1 country
- Digital Technology for Sleep and HomelessnessRecruitingNCT06620601Not applicable1 country
- Move@NUS: a Digital Intervention Cohort Promoting Healthy Movement BehavioursNot yet recruitingNCT06597890Not applicable
- Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI)RecruitingNCT04303325Phase 41 country
- Glymphatic MRI StudyNot yet recruitingNCT06452459
- Acoustic Stimulation During Restricted Sleep After Sleep DeprivationRecruitingNCT05309473Not applicable1 country