Narcolepsy clinical trials
The registry lists 149 studies for Narcolepsy across more than 10 countries. 33 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-11.
Status
- Completed
- 98
- Recruiting
- 26
- Terminated
- 6
- Status unknown
- 6
- Not yet recruiting
- 5
- Withdrawn
- 2
Phase
- Phase 3
- 33
- Phase 2
- 30
- Phase 1
- 19
- Phase 4
- 4
- Early Phase 1
- 1
Where
- United States
- 81
- France
- 42
- Canada
- 23
- Italy
- 18
- Spain
- 17
- Netherlands
- 14
Who runs them
Jazz Pharmaceuticals (16) · Takeda (10) · Hospices Civils de Lyon (8) · Bioprojet (7) · Cephalon (7) · Axsome Therapeutics, Inc. (5) · University Hospital, Montpellier (5) · Harmony Biosciences Management, Inc. (4)
Studies
Recruiting first, then most recently updated. Showing 50 of 149 — search for more.
- A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of HypersomnolenceRecruitingNCT07598708Phase 2/31 country
- A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)RecruitingNCT07540364Phase 31 country
- A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1RecruitingNCT07455383Phase 39 countries
- A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With NarcolepsyRecruitingNCT07675135Phase 32 countries
- A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IHRecruitingNCT07625280Phase 31 country
- Hypersomnia in the Paediatric PopulationNot yet recruitingNCT07766343Not applicable1 country
- A Trial to Test the Safety and Tolerability of Lu AH69593 in Adults That Are Healthy or Have NarcolepsyRecruitingNCT07613710Phase 11 country
- A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic HypersomniaRecruitingNCT06767683Phase 2/38 countries
- Decreasing Nightmares in Adults With NarcolepsyRecruitingNCT06383806Not applicable1 country
- A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)RecruitingNCT07633301Phase 27 countries
- WAKIX® (Pitolisant) Pregnancy RegistryRecruitingNCT055360111 country
- Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their TreatmentsEnrolling by invitationNCT053714831 country
- Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic HypersomniaRecruitingNCT05773872Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of E2086 in Adults With NarcolepsyRecruitingNCT07493265Phase 210 countries
- A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic HypersomniaRecruitingNCT07096674Phase 24 countries
- Proteomics and Metabolomics of Body Fluid in Patients With NarcolepsyRecruitingNCT062792471 country
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT048066201 country
- Extended-release Sodium Oxybate in ChildrenRecruitingNCT06809803Phase 21 country
- A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic HypersomniaRecruitingNCT07006233Not applicable1 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931682 countries
- The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake DisordersRecruitingNCT06797284Not applicable1 country
- Genetic and Clinical Characterization of Type 1 and 2 Narcolepsy in Adult and Pediatric Black and North African PopulationsNot yet recruitingNCT067863771 country
- Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM IntrusionsRecruitingNCT06457945Not applicable1 country
- Mentalizating in Adults Suffering from Narcolepsy Type 1.RecruitingNCT063360571 country
- A Eight-Week Study of NLS-2 (Mazindol Extended Release) in Participants With Narcolepsy Type 1Not yet recruitingNCT05914194Phase 3
- SUNOSI® (Solriamfetol) Pregnancy RegistryRecruitingNCT064134201 country
- Contribution of 7 Tesla MRI of the Hypothalamus in the Diagnosis of Type 1 NarcolepsyRecruitingNCT05967832Not applicable1 country
- A Pilot Observational Study to Assess the Ability of Continuous 'Home' EEG to Accurately Diagnose Narcolepsy and Demonstrate Response to TreatmentNot yet recruitingNCT05983731
- Treating Comorbid Depression of Patients With Narcolepsy by Intermittent Theta Burst StimulationRecruitingNCT05884112Not applicable1 country
- Discovering Factors in Narcolepsy Patients' Clinical Research ExperiencesNot yet recruitingNCT05870735
- International Swiss Primary Hypersomnolence and Narcolepsy Cohort StudyRecruitingNCT043309631 country
- Mainz Register of Patients With Sleep DisordersRecruitingNCT053213551 country
- The Value of Combined Detection of Orexin-A, HLA Gene, PSG and MSLT in the Evaluation of Patients With NarcolepsyEnrolling by invitationNCT049408061 country
- A Trial of TAK-861 for the Treatment of Narcolepsy With CataplexyActive, not recruitingNCT07363720Phase 37 countries
- A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or NarcolepsyCompletedNCT05875974Phase 42 countries
- Clarithromycin Mechanisms in Hypersomnia SyndromesCompletedNCT04026958Phase 21 country
- Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With HypersomnolenceCompletedNCT05615584Not applicable1 country
- Narcolepsy Nightmare StudyCompletedNCT05709873Not applicable1 country
- Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)CompletedNCT03881852Phase 21 country
- A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201)CompletedNCT06358950Phase 28 countries
- Study of Psychological, Sociological and Professional Factors Associated With Maintenance of Wakefulness TestCompletedNCT065861381 country
- A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With NarcolepsyCompletedNCT05059223Phase 32 countries
- Imagery Control Therapy and Lucid Dreaming for REM-Related Symptoms in NarcolepsyCompletedNCT07609537Not applicable1 country
- Method of Assessment of Driving Ability in Patients Suffering From Wakefulness PathologiesCompletedNCT00916253Not applicable1 country
- A Switch Study From High-Sodium Oxybate to Xywav to Evaluate Changes in Blood Pressure in Participants With NarcolepsyCompletedNCT05869773Phase 45 countries
- Study of MK-6552 in Participants With Narcolepsy Type 1 (MK-6552-004)TerminatedNCT06179407Phase 11 country
- A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1TerminatedNCT06961266Phase 11 country
- A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 2CompletedNCT06555783Phase 28 countries
- Observational Study of LUMRYZ in NarcolepsyCompletedNCT067927081 country
- Metabolism Characteristics in the Children With NarcolepsyCompletedNCT02799849Not applicable1 country