DrugSupplement
Caffeine clinical trials
Also written Vivarin.
Includes 35 studies of Caffeine citrate.
- studies test it
- 266
- open now
- 36
- in phase 3
- 28
- first study started
- 1995
Keep track of what changes. Save the Caffeine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Other names
Studies by the year they started
264 studies that test it; most in 2026 (26); 1 more planned to start later
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1998 | 1 |
| 1999 | 2 |
| 2000 | 2 |
| 2001 | 1 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 1 |
| 2005 | 4 |
| 2006 | 1 |
| 2007 | 4 |
| 2008 | 6 |
| 2009 | 9 |
| 2010 | 7 |
| 2011 | 9 |
| 2012 | 7 |
| 2013 | 12 |
| 2014 | 11 |
| 2015 | 7 |
| 2016 | 16 |
| 2017 | 10 |
| 2018 | 9 |
| 2019 | 15 |
| 2020 | 12 |
| 2021 | 9 |
| 2022 | 11 |
| 2023 | 23 |
| 2024 | 22 |
| 2025 | 20 |
| 2026 | 26 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 10
- Phase 1
- 59
- Phase 2
- 26
- Phase 3
- 28
- Phase 4
- 22
- No phase
- 131
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 55 · Other 211
Boehringer Ingelheim (11) · University of Alcala (6) · University of Chicago (5) · National Taiwan Sport University (5) · GlaxoSmithKline (5) · Chih-Hui Chiu (4) · Northumbria University (4) · Uppsala University (4)
Often tested with
Tested in the same studies.
Midazolam (30) · Omeprazole (19) · Acetaminophen (10) · Warfarin (9) · Dextromethorphan (7) · Ibuprofen (7) · Metoprolol (6) · Digoxin (6)
Studies
Open first, then newest update. How each study uses Caffeine is read from its arms, and is right about nine times in ten.
Testing it · 266
- Oxygen Toxicity: Mechanisms in HumansRecruitingNot applicableDuke UniversityNCT05761756Written as Caffeine
- Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear CellsNot yet recruitingNot applicablePontificia Universidad Catolica de ChileNCT07873047Written as Caffeine (5 mg/kg)
- DDI Study of ECC0509 With Metformin, Midazolam, and CaffeineNot yet recruitingPhase 1EccogeneNCT07873229Written as Caffeine
- Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill RunRecruitingNot applicableSt. Louis UniversityNCT07854223Written as Caffeine
- Placebo Effect on Cycling Performance: Laboratory Crossover StudyNot yet recruitingNot applicablePoznan University of Physical EducationNCT07748429Written as Caffeine (6mg/kg)
- Improving Preterm Kidney Outcomes With CaffeineRecruitingPhase 2University of Wisconsin, MadisonNCT07262060Written as Caffeine citrate
- TCP-600 Supplementation and Performance Response in Professional Football PlayersRecruitingNot applicableVizja University in WarsawNCT07710547Written as Caffeine
- Predicting Response and Exposure Changes in Cirrhosis for EffectivenessNot yet recruitingNot applicableAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT07750587Written as Five-Drug CYP Probe Cocktail
- The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.Not yet recruitingNot applicablePoznan University of Physical EducationNCT07748416Written as Caffeine
- Placebo Effect in Field-Based Physical PerformanceNot yet recruitingNot applicablePoznan University of Physical EducationNCT07742150Written as Caffeine (6mg/kg)
- Caffeine Optimization for Oxygen Saturation Index in ELBW InfantsRecruitingPhase 2University of RochesterNCT07216365Written as Caffeine Citrate
- Effects of L-Tyrosine and Caffeine on Performance in Elite BoxersNot yet recruitingNot applicableInonu UniversityNCT07530185Written as Caffeine
- Caffeine for Hypoxic Ischemic EncephalopathyRecruitingPhase 3NICHD Global Network for Women's and Children's HealthNCT06855108Written as Caffeine citrate oral solution
- Caffeine Citrate in Preterm Infants at Risk of Apnea in ZambiaRecruitingPhase 4University of Alabama at BirminghamNCT06518603Written as Caffeine citrate 20mg/kg/day
- Caffeine and Prophylactic Noradrenaline Requirement During Cesarean DeliveryNot yet recruitingNot applicableCairo UniversityNCT07655245Written as Caffeine (200 mg)
- Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail ApproachRecruitingEarly Phase 1Washington State UniversityNCT06693960Written as Drug cocktail
- Pharmacokinetics and Placental Transfer of CaffeineRecruitingPhase 1Indiana UniversityNCT07570121Written as Caffeine citrate
- CAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO)Not yet recruitingPhase 2University of AlbertaNCT06972108Written as Caffeine citrate
- Caffeine Strategies and Fat OxidationEnrolling by invitationNot applicableUniversidad Rey Juan CarlosNCT07402902Written as Caffeine (Guinama Anhydrous Powder)
- Effect of CAFfeine on Cognition in Alzheimer's DiseaseRecruitingPhase 3University Hospital, LilleNCT04570085Written as Caffeine
See all 266 studies that test Caffeine →
Given in every arm · 14 — Caffeine is usual care beside what is tested
- Effects of Kudzu Root (Gegen) on Drug-Metabolizing Enzymes and Blood Clotting in Healthy VolunteersCompletedPhase 1Chinese University of Hong KongNCT07823140Written as Arm 1: Six-probe drug cocktail
- A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate CancerActive, not recruitingPhase 1Aragon Pharmaceuticals, Inc.NCT02592317Written as Drug Cocktail
- BHB and Cognition During Exercise-Heat StressCompletedNot applicableUniversity of South CarolinaNCT07010666Written as Caffeine
- A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy ParticipantsCompletedPhase 1PfizerNCT05067439Written as Caffeine
- A Study of Mirikizumab in Participants With Plaque PsoriasisCompletedPhase 1Eli Lilly and CompanyNCT03718884Written as Drug Cocktail
- Licorice Botanical Dietary Supplements - Metabolism and Safety in WomenCompletedPhase 1University of Illinois at ChicagoNCT03948243Written as Caffeine 100 MG
- A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)CompletedPhase 1Merck Sharp & Dohme LLCNCT01275170Written as Caffeine
- Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy SubjectsCompletedPhase 1H. Lundbeck A/SNCT04275115Written as Drug Cocktail
- Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for CesareanCompletedPhase 4Cairo UniversityNCT03910088Written as Caffeine
- A Study of Ixekizumab in Participants With Plaque PsoriasisCompletedPhase 1Eli Lilly and CompanyNCT02993471Written as Drug Cocktail
- Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809CompletedPhase 1GlaxoSmithKlineNCT00437632Written as Caffeine
- Effects of Caffeine and Coffee on Resting Metabolic Rate, Comparing Normal Weight Men to Obese MenCompletedPhase 3Tel Hai CollegeNCT02751840Written as Caffeine
- Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic RateCompletedEarly Phase 1Pennington Biomedical Research CenterNCT02135965Written as 100mg of Caffeine
- Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3TStatus unknownEarly Phase 1Mclean HospitalNCT01747590Written as Caffeine
As the comparator · 15 — what is tested is compared with Caffeine
- Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football PlayersCompletedNot applicableVizja University in WarsawNCT07696052Written as Taurine Plus Caffeine
- Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive GamersCompletedNot applicableNorthumbria UniversityNCT07047105Written as Caffeine 75mg
- Effects of Energy Drink on Repeated Sprint Performance and Cognitive Function in AthletesCompletedNot applicableChien-Wen HouNCT07104188Written as Caffeine
- Caffeine for Hypoxic-Ischemic EncephalopathyCompletedPhase 1University of North Carolina, Chapel HillNCT03913221Written as Caffeine Citrate 5 mg/kg
- The Acute Effects of Caffeine on Exercise and CognitionCompletedPhase 4Western University, CanadaNCT03400423Written as Caffeine
- The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine DeprivationCompletedPhase 2/3Western University, CanadaNCT05170464Written as Caffeine Powder
- Effect of Coffeeberry on Mood and Cognitive PerformanceCompletedNot applicablePepsiCo Global R&DNCT04975802Written as Caffeine
- Placebo Effects Investigated by Different Experimental DesignsStatus unknownNot applicableUniversity of Sao PauloNCT04317157Written as Caffeine
- An Evaluation of the Effects of a Non-Caffeinated Energy Dietary SupplementCompletedNot applicableNova Southeastern UniversityNCT04895800Written as Caffeine
- Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy MalesCompletedNot applicableFlorida State UniversityNCT02214290Written as Caffeine
- Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)CompletedPhase 2State University of New York - Downstate Medical CenterNCT02344225Written as Caffeine citrate
- Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular TreatmentCompletedPhase 3EMSNCT02862977Written as Cyclobenzaprine with caffeine
- Efficacy of ONE A DAY Weightsmart Advanced Versus Caffeine and Placebo on Energy Expenditure, Thermogenesis and Perceived Energy Levels in Women.CompletedPhase 4BayerNCT00781586Written as Caffeine
- Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?CompletedPhase 4Radboud University Medical CenterNCT00851175Written as caffeine
- The Role of Tea Catechins and Caffeine in Relation to Energy MetabolismCompletedNot applicableUniversity of CopenhagenNCT00611416Written as Caffeine
Codes
What other systems call Caffeine · ClinicalTrials.gg INT007112
- MeSH (NLM) D002110CaffeineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 3G6A5W338ECAFFEINEConfirmed FDA, NLM, Wikidata
- RxNorm 1886Confirmed FDA, Wikidata
- Wikidata Q60235caffeineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C328CaffeineOne source FDA
- DrugBank DB00201One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002110 | Caffeine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 3G6A5W338E | CAFFEINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1886 | — | Confirmed FDA, Wikidata |
| Wikidata | Q60235 | caffeine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C328 | Caffeine | One source FDA |
| DrugBank | DB00201 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.