Drug
Ibuprofen clinical trials
Also written Motrin and Advil.
Includes 3 studies of Ibuprofen sodium dihydrate.
- studies test it
- 432
- open now
- 33
- in phase 3
- 81
- first study started
- 1990
Keep track of what changes. Save the Ibuprofen studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
424 studies that test it; most in 2012 (33)
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 1 |
| 2001 | 1 |
| 2002 | 8 |
| 2003 | 5 |
| 2004 | 7 |
| 2005 | 11 |
| 2006 | 4 |
| 2007 | 13 |
| 2008 | 9 |
| 2009 | 10 |
| 2010 | 17 |
| 2011 | 19 |
| 2012 | 33 |
| 2013 | 24 |
| 2014 | 21 |
| 2015 | 29 |
| 2016 | 22 |
| 2017 | 26 |
| 2018 | 24 |
| 2019 | 21 |
| 2020 | 19 |
| 2021 | 13 |
| 2022 | 25 |
| 2023 | 22 |
| 2024 | 16 |
| 2025 | 12 |
| 2026 | 9 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 11
- Phase 1
- 64
- Phase 2
- 67
- Phase 3
- 81
- Phase 4
- 125
- No phase
- 100
What it is tested for
Each study’s main condition, where its own words name it.
- Pain
- 3
Who runs them
Industry 111 · Other 321
Pfizer (15) · Cumberland Pharmaceuticals (12) · Cairo University (9) · Reckitt Benckiser Healthcare (UK) Limited (6) · Pamukkale University (6) · Boehringer Ingelheim (6) · Dr. Reddy's Laboratories Limited (6) · Inonu University (5)
Often tested with
Tested in the same studies.
Acetaminophen (108) · Ketorolac (13) · Diclofenac (10) · Oxycodone (10) · Hydrocodone (8) · Celecoxib (7) · Ibuprofen Injection (7) · Caffeine (7)
Studies
Open first, then newest update. How each study uses Ibuprofen is read from its arms, and is right about nine times in ten.
Testing it · 432
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids TrialRecruitingPhase 4University of MichiganNCT06671002Written as Ibuprofen
- Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New InjuriesEnrolling by invitationPhase 4State University of New York at BuffaloNCT07393503Written as Ibuprofen 200Mg Oral Tablet
- Post-Vasectomy Pain StudyRecruitingPhase 1Columbia UniversityNCT07824258Written as ibuprofen
- Impact of Preemptive Analgesia on Postoperative Pain in Orthognathic SurgeryRecruitingPhase 4University of Puerto RicoNCT07571252Written as ibuprofen
- Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain ManagementNot yet recruitingPhase 3University Hospital, Basel, SwitzerlandNCT07682558Written as Ibuprofen
- Pain Control During ESWL Using Non-Opioid AnalgesicsNot yet recruitingPhase 4University of GaziantepNCT07512297Written as Ibuprofen (Brufen®)
- Role of Alprazolam in Management of Post Endodontic Pain After Single Visit Root Canal Treatment. To Compare Mean Pain Score Between Two Group of Participants Undergoing Post Operative Pain Management After Single Visit Root Canal Treatment: NSAIDs Alone and a Combination of NSAIDs and Alprazolam.RecruitingNot applicableArmed Forces Post Graduate Medical Institute (AFPGMI), RawalpindiNCT07275710Written as Brufen and alprazolam
- The Effect of Different Intra-canal Medications on Postoperative PainRecruitingEarly Phase 1Cairo UniversityNCT07603934Written as ibuprofen
- Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain ManagementRecruitingEarly Phase 1University of Colorado, DenverNCT04059172Written as Ibuprofen 200 mg and acetaminphen 650 mg
- Paracetamol and Ibuprofen With or Without Famotidine for Calcific Tendinitis of the ShoulderNot yet recruitingNot applicableUniversity Hospital DubravaNCT07539961Written as Paracetamol + Ibuprofen + Famotidine
- Supracondylar Post-Operative Pain StudyRecruitingPhase 4University of California, Los AngelesNCT03759028Written as Ibuprofen
- Non-Steroidal Anti-Inflammatory Drugs in Acute MyocarditisRecruitingPhase 3Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIINCT06686862Written as ibuprofen
- Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung VentilationNot yet recruitingNot applicableOndokuz Mayıs UniversityNCT07399184Written as ibuprofen
- Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic SurgeryRecruitingPhase 4Sanford HealthNCT03858231Written as Ibuprofen 600 mg
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIHRecruitingNot applicableOctober University for Modern Sciences and ArtsNCT07374354Written as ibuprofen 100mg/ml oral suspension syrup
- Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific AntigenRecruitingPhase 4University of ChicagoNCT05512754Written as Ibuprofen 400 mg
- Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGDRecruitingPhase 2IRCCS San RaffaeleNCT03055247Written as Ibuprofen
- Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain ManagementRecruitingNot applicableAtaturk UniversityNCT06937853Written as Ibuprofen 600 mg
- A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in AdultsNot yet recruitingNot applicableS.LAB (SOLOWAYS)NCT06269406Written as ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg
- Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean SectionRecruitingPhase 4Seoul National University HospitalNCT06479122Written as Acetaminophen/Ibuprofen
See all 432 studies that test Ibuprofen →
Given in every arm · 78 — Ibuprofen is usual care beside what is tested
- Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature InfantsRecruitingPhase 2Mount Sinai Hospital, CanadaNCT05340582Written as Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen)
- Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee OsteoarthritisNot yet recruitingNot applicableFederal University of São PauloNCT07766330Written as ibuprofen
- Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General AnesthesiaRecruitingPhase 4Boston UniversityNCT06757075Written as Ibuprofen
- Opioid Use After Laparoscopic SalpingectomyRecruitingPhase 4Johns Hopkins UniversityNCT06434233Written as Ibuprofen
- Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.RecruitingPhase 4Montefiore Medical CenterNCT05721027Written as Ibuprofen 400 mg
- Effect of Acupressure Versus Kinesotape on Low Back Pain in Women Who Use Intrauterine DeviceNot yet recruitingNot applicableCairo UniversityNCT06891976Written as Non-steroidal anti-inflammatory drugs
- A Study to Investigate the Analgesic Efficacy of Ibuprofen Alone and Ibuprofen Plus Hyoscine-n- Butyl Bromide in Reducing Pain of Outpatient HysteroscopyNot yet recruitingPhase 4ASST Fatebenefratelli SaccoNCT06398054Written as Ibuprofen 400 mg
- Efficacy of Thread - Embedding Acupuncture for the Treatment of Primary DysmenorrheaCompletedNot applicableUniversity of Medicine and Pharmacy at Ho Chi Minh CityNCT07844174Written as Ibuprofen 400Mg Tab
- Comparison Between 2 Techniques for Lumbar-ESPBCompletedNot applicablePapa Giovanni XXIII HospitalNCT07104097Written as Ibuprofen 400 mg
- Efficacy of Different Drugs to Control Post Root Canal Treatment PainCompletedPhase 2University of KhartoumNCT02417337Written as Ibuprofen
- Study of Post-Herniorrhaphy Non-opioid MMA RegimensCompletedPhase 3Heron TherapeuticsNCT03907176Written as Ibuprofen
- Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain ManagementCompletedPhase 4Children's Mercy Hospital Kansas CityNCT06187584Written as Ibuprofen
- Phase 2 Herniorrhaphy Study for Opioid EliminationCompletedPhase 2Heron TherapeuticsNCT03695367Written as Ibuprofen
- Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) RegimenCompletedPhase 3Heron TherapeuticsNCT03974932Written as Ibuprofen
- Mechanisms of Action of AcetaminophenCompletedNot applicableUniversity of PennsylvaniaNCT00646906Written as Ibuprofen 800 mg/d
- Opioid-Free Pain Protocol After Shoulder ArthroplastyActive, not recruitingPhase 4Henry Ford Health SystemNCT05488847Written as Ibuprofen
- Post-operative Pain Management in Children With Supracondylar Humerus FracturesTerminatedPhase 4Baylor College of MedicineNCT05640674Written as Ibuprofen
- Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological MalignanciesCompletedPhase 1City of Hope Medical CenterNCT04681105Written as Ibuprofen
- Reduced Opioid Prescription After Laparoscopic HysterectomyActive, not recruitingNot applicableJohns Hopkins UniversityNCT05548582Written as Ibuprofen 600 mg
- Prescribing Lorazepam for IUD Insertion: Pilot Feasibility StudyWithdrawnPhase 2University of Wisconsin, MadisonNCT06496854Written as Ibuprofen 800 mg
Showing 20 of 78.
As the comparator · 94 — what is tested is compared with Ibuprofen
- Post-op Analgesia of Nail Unit ProceduresNot yet recruitingPhase 4University of MiamiNCT07820969Written as Ibuprofen
- Suzetrigine Versus Standard Analgesia After Skin Cancer SurgeryNot yet recruitingPhase 4University of MinnesotaNCT07843134Written as Acetaminophen Plus Ibuprofen
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator PlacementRecruitingPhase 2Rush University Medical CenterNCT07487246Written as oral ibuprofen
- Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic PainNot yet recruitingNot applicableBahria UniversityNCT07638644Written as Ibuprofen 400 mg (if necessary)
- Hard Splint Vs Conservative Therapy for TMJ Pain ManagementNot yet recruitingNot applicableKhyber College of dentistryNCT07573137Written as Topical Ibuprofen gel
- Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in ChildrenRecruitingPhase 3University of CalgaryNCT07145645Written as Ibuprofen Oral Suspension 100 mg/5mL
- Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar SurgeryRecruitingNot applicableOman Medical Speciality BoardNCT07244029Written as Ibuprofen 400 mg
- Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled TrialRecruitingPhase 3Major Extremity Trauma Research ConsortiumNCT07006675Written as 600 mg Ibuprofen
- Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac DiseaseNot yet recruitingPhase 4Cairo UniversityNCT06149507Written as Ibuprofen
- Efficacy and Safety in the Combination of Ibuprofen / Loratadine Versus Ibuprofen Versus LoratadineCompletedPhase 3Laboratorios Silanes S.A. de C.V.NCT06531707Written as Ibuprofen
- Palmitoylethanolamide vs Ibuprofen for Pain After ESWLCompletedNot applicableBenha UniversityNCT07316660Written as Ibuprofen (Brufen®)
- Curcumin Versus Ibuprofen for Exercise-Induced Muscle Damage in Physically Active WomenCompletedNot applicableUniversity of ValladolidNCT07785986Written as Ibuprofen
- Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic SurgeryCompletedNot applicableUniversity of Nove de JulhoNCT05935306Written as Ibuprofen
- Botulinum Toxin Type A Versus Oral Ibuprofen for BruxismCompletedPhase 4NEW Cyprus Health and Social Sciences UniversityNCT07732751Written as Ibuprofen
- Open-Label Placebo for Non-Specific Pain in the EDCompletedNot applicableBruno MinottiNCT06408519Written as Ibuprofen 400 mg
- Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus ArteriosusCompletedPhase 3Máximo Vento TorresNCT04037514Written as Ibuprofen
- Ibuprofen and Neural Mobilization Treatment in Carpal Tunnel Syndrome.CompletedPhase 4Universidad Europea de MadridNCT04328805Written as ibuprofen tablets
- Pentoxifylline and Lumbar RadiculopathyActive, not recruitingPhase 4St Joseph University, Beirut, LebanonNCT03060434Written as Ibuprofen
- Effect of Over-the-counter Analgesics on Postoperative PainCompletedPhase 3Zitelli & Brodland Skin Cancer CenterNCT06948513Written as ibuprofen
- Dexamethasone Treatment for Patients Undergoing EndodonticsCompletedPhase 4University of SalamancaNCT06906315Written as Ibuprofen group
Showing 20 of 94.
Codes
What other systems call Ibuprofen · ClinicalTrials.gg INT007644
- MeSH (NLM) D007052IbuprofenConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) WK2XYI10QMIBUPROFENConfirmed FDA, NLM, Wikidata
- RxNorm 5640Confirmed FDA, Wikidata
- Wikidata Q186969ibuprofenConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C561IbuprofenOne source FDA
- DrugBank DB01050One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D007052 | Ibuprofen | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | WK2XYI10QM | IBUPROFEN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 5640 | — | Confirmed FDA, Wikidata |
| Wikidata | Q186969 | ibuprofen | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C561 | Ibuprofen | One source FDA |
| DrugBank | DB01050 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.