An interventional study of ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg and ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg in Dental Pain, sponsored by S.LAB (SOLOWAYS). Not yet recruiting at 1 site in Russian Federation. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2025-06-08.
Sponsored by S.LAB (SOLOWAYS) · Not applicable, Interventional, and Treatment
Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.
142 studies on the registry are indexed under Toothache; 28 are open to participants now.
This study's planned enrollment of 264 is above the median of 84 across 123 interventional studies indexed under Toothache.
Browse Toothache studies →S.LAB (SOLOWAYS) is the lead sponsor of 29 studies on the registry; 7 are open to participants now.
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Exclusion Criteria:
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Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg
Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg
Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure
Drug page: Ibuprofen
The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure
Drug page: Ibuprofen
The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure
The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure
Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points)
Time frame: 8 hours
Total pain relief (TOTPAR) %
Time frame: 8 hours
Time to pain half pain gone (in minutes)
Time frame: 8 hours
Duration of pain half gone (in minutes)
Time frame: 8 hours
Any adverse events (facial swelling, nausea, vomiting, headache) (%)
Time frame: 8 hours
This study is not yet recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Ibuprofen
S.LAB (SOLOWAYS)