Low Back Pain clinical trials
The registry lists 2,922 studies for Low Back Pain across more than 10 countries. 580 are recruiting or about to start. 2,524 of them are mainly about Low Back Pain (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 3,490 studies for Low Back Pain. How that becomes 2,918 here
This page counts the studies the registry files under Low Back Pain, and those it files under no condition that list Low Back Painthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 3,490Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −297List Low Back Pain as a condition, but the registry did not file them under itMost often written as “Chronic Low Back Pain” (106), “Chronic Low-back Pain” (78), and “Chronic Low Back Pain (CLBP)” (20). The registry filed them under other conditions only, most often Pain (64) and Chronic Pain (58).
- −282Match it another way208 name it in the title, 19 in a keyword, and 55 by a synonym or other text the search reads.
- 2,911Counted here and found by its search541 of them list Low Back Pain in their own words; the registry filed them under no condition.
- +7
Counted here, but its search does not find them
- Syringe Pressure Analysis: A Critical Examination of the Operator's BurdenNCT06476353
- Interprofessional Management of Chronic Back Pain in Rural and Remote Setting: Use of Telehealth vs. Secure Laptop-based VideoconferencingNCT02960269
- Internet-based Cognitive Behavioural Treatment for Chronic Back PainNCT01329861
- Validation of the French Version of the Back Belief QuestionnaireNCT01389999
- MOTIVATE: Moving to Improve Outcomes for Older AdultsNCT03914469
- The Impact of an Instructional Web-based Healthcare App for Relieving Back Pain From Spinal Compression FracturesNCT05386212
- EVOKE ECAP-Controlled Lead Placement and Programming in Chronic Pain PatientsNCT05704751
- 2,918The count on this page
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Status
Who runs them
Riphah International University (118) · Cairo University (74) · Hacettepe University (28) · Foundation University Islamabad (25) · Assistance Publique - Hôpitaux de Paris (20) · University of Utah (20) · University of Florida (20) · VA Office of Research and Development (18)
What is being tested here
Drugs under test in Low Back Pain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 3 | 1 | 4 |
| Adezunap | 2 | 2 | 2 |
| Ibuprofen | 1 | 0 | 7 |
| Diclofenac | 1 | 1 | 5 |
| Methylprednisolone | 1 | 1 | 5 |
| Methylprednisolone Acetate | 1 | 0 | 3 |
| Glucose | 1 | 1 | 3 |
| Duloxetine | 1 | 0 | 3 |
| Cannabis sativa subsp. indica TOP | 1 | 0 | 2 |
| Naloxone | 1 | 0 | 2 |
Drug classes tested here Corticosteroids 3 open · NSAIDs 2 open · Local anesthetics 1 open · SNRIs 1 open · Opioid antagonists 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Melatonin for Patients With Chronic Low Back Pain · Phase 3 · Bart Koes
- Jun 2027Home-based Cycling for People With Lumbar Spinal Stenosis · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Aug 2027Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial · Phase 3 · Bart Koes
- Nov 2027A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease · Phase 3 · DiscGenics, Inc.
- Nov 2026A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE · National University of Natural Medicine
- Nov 2026Back to Life - Early Rehabilitation Therapy for Patients Undergoing Lumbar Spinal Fusion · Rigshospitalet, Denmark
- Nov 2026Trial to Test the Efficacy of Using Magnetic Fields to Stimulate the Back to Treat Chronic Lower Back Pain. · Joe X. Zhang
- Nov 2026Ultrasound-Guided Proximal Superior Cluneal Nerve Block for Superior Cluneal Nerve Entrapment · Gaziosmanpasa Research and Education Hospital
- Nov 2026Effectiveness of the SelfBack-App in Preventing and Treating Low Back Pain Versus no Intervention: a Non-randomized Clinical Trial · Universitair Ziekenhuis Brussel
- Nov 2026Strain Counter Strain and Muscle Energy Technique in Non-specific Low Back Pain · Riphah International University
Who these studies take
Of the 333 Low Back Pain studies recruiting now, 92 (28%) set no upper age limit and 211 (63%) stop at 75 or younger. 8 (2%) take children under 18. 17 (5%) are for women only and 2 (1%) for men only; 46 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (2%) | 5 (2%) |
| 18 | 251 (75%) | 245 (74%) |
| 30 | 310 (93%) | 298 (89%) |
| 40 | 309 (93%) | 298 (89%) |
| 50 | 271 (81%) | 266 (80%) |
| 65 | 222 (67%) | 221 (66%) |
| 75 | 137 (41%) | 137 (41%) |
| 85 | 109 (33%) | 109 (33%) |
Across all 2,922 studies, recruiting or not: 65% stop at 75 or younger and 53% at 65; 4% take children; 6% are for women only and 1% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Low Back Pain studies take
Of 35 phase 3 interventional studies under Low Back Pain, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 13 mo11–43 · 33 studies | — | — |
| Phase 3 | 31 mo16–40 · 35 studies | — | — |
| Phase 4 | 20 mo14–53 · 33 studies | — | — |
| Interventional, no phase | 11 mo5–27 · 1,286 studies | 19 mo12–44 · 55 studies | 11 mo5–26 · 1,231 studies |
| Observational | 24 mo10–48 · 185 studies | — | 24 mo10–48 · 175 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Conventional vs Pulsed RF in CoccydyniaOct 28, 2026NCT07497269
- The Intervention Effect of Exercise on Lumbar Multifidus Muscle InjuriesOct 28, 2026NCT07892846
- EFFICACY OF ARTIFICIAL INTELLIGENCE DRIVEN PROGRAM VERSUS TRADITIONAL PHYSICAL THERAPY PROGRAM IN PATIENTS WITH LOW BACK DYSFUNCTIONOct 21, 2026NCT07749833
- Comparing Myofascial Exercise and Trigger Point Therapy for Non-Specific Low Back PainOct 13, 2026NCT07362420
Results posted2
- Effects of Sleep Disruption on Drug ResponseOct 21, 2026NCT03680287
- Soft Active Back Exosuit to Reduce Workplace Back PainOct 14, 2026NCT05802914
Stopped1
- Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBPTerminatedOct 26, 2026NCT02521519
Newly registered18
- Study Designed to Assess the Efficacy and Safety of the Neurolyser XR After Marketing ApprovalNov 9, 2026NCT07926581
- Neuromuscular Taping on Muscle Pain in Patients With Degenerative Osteoarticular Disease of the SpineNov 9, 2026NCT07926789
- Effects of Hip Hinge Exercises on Pain, Range of Motion and Functional Disability in Non-specific Low Back Pain.Nov 6, 2026NCT07921056
- Effects of IASTM, Deep Friction Massage, and Sham Instrument-Assisted Soft Tissue Mobilization on Electromyographical Activation, Pain and Function in Non-Specific Low Back PainNov 6, 2026NCT07921784
- Effectiveness of a Workplace-Based Core Stability Exercise Program in Reducing Occupational Low Back Pain Among Hospital Nurses: A Quasi-Experimental StudyNov 6, 2026NCT07923435
Show 13 moreShow fewer
- Evaluation of a Program to Prevent Recurrences of Episodes of Acute Low Back Pain, Assisted by the Axomove ApplicationNov 4, 2026NCT07915128
- The Influence of Hydration on the Viscoelastic Properties of Soft Tissues, Pain and Mobility of PatientsNov 4, 2026NCT07915167
- Effects of Spinal Mobilization With and Without Clinical Pilates in Patients With Lumbar Disc Herniationc HerniationNov 3, 2026NCT07912047
- Integrated Feldenkrais Method With and Without DNS for Chronic Low Back Pain in FemalesNov 3, 2026NCT07912060
- Comparative Effects of Kinetic Control Training and Neural Mobilization in Lumbar RadiculopathyNov 3, 2026NCT07912073
- A Novel Treatment for Chronic Low Back Pain Using Multi Angular Isometric Lumbar Exercise: Randomized Clinical Trial.Nov 2, 2026NCT07908693
- The Effectiveness of Pilates Exercise on Chronic Low Back Pain of The Older AdultsNov 2, 2026NCT07910669
- Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal DisordersOct 29, 2026NCT07903142
- Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE)Oct 23, 2026NCT07892079
- The Intervention Effect of Exercise on Lumbar Multifidus Muscle InjuriesOct 23, 2026NCT07892846
- Gamified Home-Based Core Neuromuscular Training for Chronic Low Back PainOct 22, 2026NCT07890363
- Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional TherapyOct 16, 2026NCT07877454
- Effects of Virtual Reality Exergames Versus Spinal Manipulation in Chronic Nonspecific Low Back PainOct 15, 2026NCT07876960
Studies
Recruiting first, then most recently updated. Showing 50 of 2,922. Browse all 2,922 → or search them.
- Analysis of Crepitus in Human SubjectsNot yet recruitingNCT054250171 country
- Fluoroscopy-Guided Lumbar Facet Block for Chronic Low Back PainNot yet recruitingNCT079296231 country
- PerQdisc Traditional Feasibility Trial.RecruitingNCT06860867Not applicable1 country
- Gamified Home-Based Core Neuromuscular Training for Chronic Low Back PainNot yet recruitingNCT07890363Not applicable
- Neuromuscular Taping on Muscle Pain in Patients With Degenerative Osteoarticular Disease of the SpineNot yet recruitingNCT07926789Not applicable1 country
- Study Designed to Assess the Efficacy and Safety of the Neurolyser XR After Marketing ApprovalNot yet recruitingNCT079265811 country
- Brain Connectivity and Perceptive Surfaces in Chronic Low Back Pain (SUPER-RMNf)Not yet recruitingNCT07568353Not applicable1 country
- Comparing Non-Medicine Strategies for Improving Low Back PainNot yet recruitingNCT07679178Not applicable1 country
- Effects of Whole-Body Vibration and Cervical Stabilization With Core Stabilization in Young Adults With Non-Specific Low Back PainNot yet recruitingNCT07921771Not applicable1 country
- Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back PainNot yet recruitingNCT07696507Not applicable1 country
- Effects of Hip Hinge Exercises on Pain, Range of Motion and Functional Disability in Non-specific Low Back Pain.Not yet recruitingNCT07921056Not applicable1 country
- Effect of Lumbar Stabilization Exercises With and Without YTWL (Scapular Stabilization Exercises) on Reducing Chronic Low Back Pain and Related Disability. A Randomized Clinical Trial,Not yet recruitingNCT07845760Not applicable1 country
- Effects of IASTM, Deep Friction Massage, and Sham Instrument-Assisted Soft Tissue Mobilization on Electromyographical Activation, Pain and Function in Non-Specific Low Back PainNot yet recruitingNCT07921784Not applicable
- Pilot Study: Clinical Trial of Ultrasound Guiding Pharmacopuncture Therapy for Acute Low Back PainNot yet recruitingNCT07126951Not applicable1 country
- The Influence of Hydration on the Viscoelastic Properties of Soft Tissues, Pain and Mobility of PatientsEnrolling by invitationNCT07915167Not applicable1 country
- Effects of Myofascial Techniques on Chronic Low Back PainNot yet recruitingNCT07915817Not applicable
- A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back PainRecruitingNCT07641504Phase 22 countries
- Evaluation of a Program to Prevent Recurrences of Episodes of Acute Low Back Pain, Assisted by the Axomove ApplicationNot yet recruitingNCT07915128Not applicable
- Comparing Myofascial Exercise and Trigger Point Therapy for Non-Specific Low Back PainRecruitingNCT07362420Not applicable1 country
- Dual-Task Core Stabilization Training in Chronic Nonspecific Low Back PainNot yet recruitingNCT07894965Not applicable1 country
- Ultrasound-guided Percutaneous Electrical Stimulation for Gluteus Muscle Dysfunction After Low Back Pain EpisodeRecruitingNCT06873386Not applicable1 country
- Effects of Spinal Mobilization With and Without Clinical Pilates in Patients With Lumbar Disc Herniationc HerniationNot yet recruitingNCT07912047Not applicable1 country
- PRP Versus NP Injections for Chronic Discogenic Low Back PainNot yet recruitingNCT07895225Phase 2/31 country
- A Novel Treatment for Chronic Low Back Pain Using Multi Angular Isometric Lumbar Exercise: Randomized Clinical Trial.RecruitingNCT07908693Not applicable1 country
- Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet ArthropathyRecruitingNCT06965452Not applicable1 country
- Effects of Virtual Reality Exergames Versus Spinal Manipulation in Chronic Nonspecific Low Back PainRecruitingNCT07876960Not applicable1 country
- Meditation for Older Adults With Chronic Low Back PainRecruitingNCT06384001Not applicable1 country
- McGill Stabilization Exercises Versus Pilates for Chronic Low Back PainNot yet recruitingNCT07905391Not applicable1 country
- Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal DisordersNot yet recruitingNCT07903142Not applicable1 country
- Conventional vs Pulsed RF in CoccydyniaRecruitingNCT07497269Not applicable1 country
- Erector Spinae Plane Block With or Without Thoracolumbar Fascia Injection for Chronic Low Back PainNot yet recruitingNCT07900347Not applicable1 country
- The Intervention Effect of Exercise on Lumbar Multifidus Muscle InjuriesRecruitingNCT07892846Not applicable1 country
- Acceptance and Commitment Therapy Plus Physiotherapy for Chronic Low Back PainNot yet recruitingNCT07766616Not applicable
- Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back PainNot yet recruitingNCT07843706Not applicable1 country
- Psilocybin-Assisted Physical Therapy in Chronic Low Back PainNot yet recruitingNCT07306364Phase 21 country
- Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE)Not yet recruitingNCT07892079Not applicable1 country
- EFFICACY OF ARTIFICIAL INTELLIGENCE DRIVEN PROGRAM VERSUS TRADITIONAL PHYSICAL THERAPY PROGRAM IN PATIENTS WITH LOW BACK DYSFUNCTIONRecruitingNCT07749833Not applicable1 country
- Visual Feedback-Assisted Sensorimotor Training in Chronic Nonspecific Low Back PainNot yet recruitingNCT07887789Not applicable1 country
- Overlapping Pain Trajectory StudyRecruitingNCT057523961 country
- Therapeutic Exercise and Education for Low Back PainNot yet recruitingNCT07713082Not applicable1 country
- Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional TherapyNot yet recruitingNCT07877454Not applicable1 country
- Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal PainNot yet recruitingNCT06987786Not applicable1 country
- Comparison of Abdominal Expansion and Abdominal Drawing-In Training With Manual and Verbal Cueing in Chronic Non-Specific Low Back PainNot yet recruitingNCT07318454Not applicable
- Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central SensitizationNot yet recruitingNCT07866690Not applicable1 country
- A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc DiseaseRecruitingNCT07254806Phase 31 country
- Electronic Approach to the Human Massage TherapistRecruitingNCT07040397Not applicable1 country
- Immediate Effects of Manual and Verbal Cueing During Movement Control Training in Chronic Non-Specific Low Back PainRecruitingNCT07324538Not applicable1 country
- Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back PainRecruitingNCT04164225Not applicable1 country
- Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current ControlRecruitingNCT07190807Not applicable1 country
- Intracept Minimally-invasive PROcedure for VErtebrogenic Back PainRecruitingNCT068272621 country