Fever clinical trials
The registry lists 438 studies for Fever across more than 10 countries. 55 are recruiting or about to start. 227 of them are mainly about Fever (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Fever of Unknown Origin too: 454 studies, 56 open.
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Assistance Publique - Hôpitaux de Paris (9) · Assaf-Harofeh Medical Center (8) · Duke University (7) · Institute of Tropical Medicine, Belgium (6) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · Novartis Pharmaceuticals (6) · Mallinckrodt (5) · Cumberland Pharmaceuticals (5)
What is being tested here
Drugs under test in Fever studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Acetaminophen | 1 | 8 | 31 |
| Nirsevimab | 1 | 0 | 1 |
| Ascorbic Acid | 1 | 0 | 1 |
| Betamethasone sodium phosphate | 1 | 1 | 1 |
| Betamethasone | 1 | 1 | 1 |
| Ertapenem | 1 | 0 | 1 |
| Ibuprofen | 0 | 6 | 18 |
| Ciprofloxacin | 0 | 1 | 4 |
| Diclofenac | 0 | 0 | 4 |
| Caspofungin | 0 | 1 | 3 |
Drug classes tested here Corticosteroids 1 open · NSAIDs 23 · Beta-lactamase inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Triage Performance and Physiological Predictors of Serious Illness in Febrile Children in the Pediatric Emergency Department · TC Erciyes University
- Dec 2026Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE) · Helsinki University Central Hospital
- Dec 2026Recovery After Fatigue in Young Athletes: Comparison Between TECAR Therapy and Cycle Ergometer" · Maimónides Biomedical Research Institute of Córdoba
- Dec 2026Effect of Buzzy and Virtual Reality on Children Undergoing Venous Procedures · Bandırma Onyedi Eylül University
- Dec 2026Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID) · All Natural Medicine Clinic, LLC
- Dec 2026Machine Learning to Predict Fever After Labor Analgesia · Chengdu Jinjiang Maternity and Child Health Hospital
- Dec 2026Analysis of the Virtual Acute Care at Home Experience · OSF Healthcare System
- Feb 2027Diathermy On Diabetes Glucose Monitoring Effectiveness · University of Nottingham
- Feb 2027Safety of RSV Preventive Monoclonal Antibody · Duke University
- Mar 2027Neuroendocrine Response in Pediatric Febrile Seizures · Aydin Adnan Menderes University
Who these studies take
Of the 38 Fever studies recruiting now, 18 (47%) set no upper age limit and 14 (37%) stop at 75 or younger. 22 (58%) take children under 18. 2 (5%) are for women only and 0 (0%) for men only; 11 (29%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 15 (39%) | 15 (39%) |
| 18 | 29 (76%) | 27 (71%) |
| 30 | 27 (71%) | 25 (66%) |
| 40 | 26 (68%) | 25 (66%) |
| 50 | 25 (66%) | 24 (63%) |
| 65 | 25 (66%) | 24 (63%) |
| 75 | 24 (63%) | 23 (61%) |
| 85 | 24 (63%) | 23 (61%) |
Across all 438 studies, recruiting or not: 46% stop at 75 or younger and 43% at 65; 54% take children; 8% are for women only and 2% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Fever studies take
Of 16 phase 4 interventional studies under Fever, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 17 mo11–42 · 16 studies | — | — |
| Interventional, no phase | 16 mo6–30 · 74 studies | — | 17 mo7–30 · 66 studies |
| Observational | 22 mo8–36 · 61 studies | — | 22 mo8–47 · 51 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
- Swiss 2024 Continous Fever Monitoring in Pediatric Oncology PatientsOct 22, 2026NCT05940766
Results posted1
- Continuos Body Temperature MonitoringNov 4, 2026NCT06447337
Stopped1
- Using a Decision-making System to Support the Management of Fever and Acute Pain in ChildrenTerminatedOct 13, 2026NCT07344090
Newly registered3
- Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical TrialOct 30, 2026NCT07906925
- Accuracy of Moni-Patch Compared With Tympanic Temperature Monitoring in Adults at Risk of FeverOct 28, 2026NCT07900386
- Effect of Buzzy and Virtual Reality on Children Undergoing Venous ProceduresOct 20, 2026NCT07882602
Studies
Recruiting first, then most recently updated. Showing 50 of 438. Browse all 438 → or search them.
- Familial Mediterranean Fever and Related Disorders: Genetics and Disease CharacteristicsRecruitingNCT000013731 country
- Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, MaliRecruitingNCT011682711 country
- Recovery After Fatigue in Young Athletes: Comparison Between TECAR Therapy and Cycle Ergometer"RecruitingNCT07547566Not applicable1 country
- Diagnosis and Management of Inflammatory and Infectious DiseasesRecruitingNCT005577261 country
- Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical TrialNot yet recruitingNCT07906925Phase 1/2
- Accuracy of Moni-Patch Compared With Tympanic Temperature Monitoring in Adults at Risk of FeverNot yet recruitingNCT07900386Not applicable1 country
- Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related ConditionsRecruitingNCT035104421 country
- Swiss 2024 Continous Fever Monitoring in Pediatric Oncology PatientsRecruitingNCT05940766Not applicable1 country
- Effect of Buzzy and Virtual Reality on Children Undergoing Venous ProceduresRecruitingNCT07882602Not applicable1 country
- Machine Learning to Predict Fever After Labor AnalgesiaNot yet recruitingNCT07880665
- Comparison of FDG-PET/CT and CECT-CAP as Upfront Imaging Modality for the Diagnosis of Pyrexia of Unknown OriginRecruitingNCT07816783Not applicable1 country
- Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic ShockRecruitingNCT04494074Not applicable1 country
- Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was PerformedRecruitingNCT016173821 country
- Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.RecruitingNCT046698861 country
- Triage Performance and Physiological Predictors of Serious Illness in Febrile Children in the Pediatric Emergency DepartmentRecruitingNCT077390041 country
- Optimizing the Care Pathway of Febrile Children Via Capillary C-reactive Protein Assay in Primary CareRecruitingNCT06910631Not applicable1 country
- Effectiveness of Best Care Practices in Acute Stroke in Conventional Hospitalization (BEST CARE ICTUS_HC)RecruitingNCT07627399Not applicable1 country
- Hemorrhage Elimination During Lumbar Puncture Using Ultrasound Measurements (HELPUS)RecruitingNCT07612644Not applicable1 country
- Efficacy and Safety of Daily Home-based Hyperthermic Baths for Reducing Epileptic Seizures in CDKL5 Deficiency Disorder: A PROBE Clinical TrialNot yet recruitingNCT07602205Not applicable
- Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome PlatformRecruitingNCT075786101 country
- Diathermy On Diabetes Glucose Monitoring EffectivenessNot yet recruitingNCT075832381 country
- Epidemiological Study on Community Acquired PneumoniaRecruitingNCT021391631 country
- Diagnostic Performance of a Combination of Leukocyte Cell Surface Markers in Predicting the Risk of Severe Bacterial Infection in Febrile Children Under Three Months of Age in the Emergency Department: a Pilot Study.RecruitingNCT066189891 country
- Intranasal Dexmedetomidine for Prevention of Intrapartum FeverNot yet recruitingNCT07501221Not applicable1 country
- Viromes in Infants Presenting With a Septic SyndromeNot yet recruitingNCT07470541Not applicable1 country
- Analysis of the Virtual Acute Care at Home ExperienceEnrolling by invitationNCT059529991 country
- Safety of RSV Preventive Monoclonal AntibodyRecruitingNCT07158814Phase 41 country
- Neuroendocrine Response in Pediatric Febrile SeizuresNot yet recruitingNCT074632221 country
- Antipyretic Therapy With and Without Cold SpongingNot yet recruitingNCT07426744Not applicable1 country
- Clinical Accuracy Validation of the Moni-Patch Temperature Monitoring Patch SystemNot yet recruitingNCT07397078Not applicable1 country
- Sulfamethoxazole Prophylaxis Duration After Renal TransplantationRecruitingNCT07231770Not applicable1 country
- The Fever Clinic Acute Respiratory CohortRecruitingNCT072787001 country
- Effect of an Intervention Combining the Use of Standardized Information and Sending an SMS Advice Message to Parents Calling the SAMU Center 15 for Uncomplicated Fever in ChildrenNot yet recruitingNCT07248488Not applicable1 country
- Masseter Muscle Stiffness After Heat Application and Percussion TherapyRecruitingNCT07237087Not applicable1 country
- The Impact of Local Anesthetic Solution Temperature on Epidural-related Maternal FeverRecruitingNCT06682416Not applicable1 country
- Etiology of Febrile Illness in Nepal (DEFINe Study)RecruitingNCT07004751Not applicable1 country
- Prescription Antipyretics to Decrease Unscheduled Return Visits In A Pediatric Emergency DepartmentRecruitingNCT07074912Not applicable1 country
- Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell PatientsRecruitingNCT070007471 country
- Study to Investigate the Efficacy and Safety of Apomivir®Not yet recruitingNCT01677689Phase 21 country
- Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis.Not yet recruitingNCT068466451 country
- Transcriptomic Responses for the Identification of PathogensRecruitingNCT048785491 country
- Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)RecruitingNCT04790240Phase 1/21 country
- Gram Stain of the First Urine After Puncture in Percutaneous NephrolithotomyRecruitingNCT06393062Not applicable1 country
- Remote Temperature Monitoring of Patients At Risk for Developing FeverRecruitingNCT06752512Not applicable1 country
- LázBarát™ (FeverFriend™) Projekt: Attitude Toward Fever and Its Change in the Healthcare SystemEnrolling by invitationNCT046336031 country
- Fever Education Given to Parents of Children Presenting to the Emergency Department With FeverRecruitingNCT06599853Not applicable1 country
- Effect of Intravenous Vitamin C on Intrapartum Maternal Fever After Epidural Labor AnalgesiaRecruitingNCT06354582Phase 41 country
- Effectiveness of a Single Dose of Betamethasone in Children With Symptomatic Adenovirus InfectionRecruitingNCT06299813Phase 31 country
- Continuous Temperature Measurement by Thermal Imaging CameraNot yet recruitingNCT06256978
- Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent TumorsNot yet recruitingNCT04889742Phase 21 country