Substance Withdrawal Syndrome clinical trials

The registry lists 74 studies for Substance Withdrawal Syndrome across more than 10 countries. 7 are recruiting or about to start. 35 of them are mainly about Substance Withdrawal Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 53
Status unknown: 8
Recruiting: 5
Not yet recruiting: 2
Active, not recruiting: 2
Withdrawn: 2

Phase

Phase 2: 16
Phase 3: 10
Phase 4: 9
Phase 1: 5

Where

United States: 35
Canada: 7
France: 5
China: 5
Norway: 2
Finland: 2

Who runs them

Spark Biomedical, Inc. (4) · Southern Illinois University Carbondale (2) · Changhai Hospital (2) · University of California, Los Angeles (2) · Wilkes University (2) · Etablissement Public de Santé Barthélemy Durand (1) · University of Massachusetts, Worcester (1) · Uppsala University (1)

What is being tested here

Drugs under test in Substance Withdrawal Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Dexmedetomidine	1	2	3
Probenecid	1	0	1
Methimazole	1	0	1
Nicotine	0	0	5
Buprenorphine	0	2	4
Naloxone	0	2	3
Methadone	0	0	2
Dasatinib	0	0	1
Nilotinib	0	0	1
Dronabinol	0	0	1

Drug classes tested here Opioids 8 · Opioid antagonists 4

Coming up

2phase 3 studies under way

3studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 3, phase 3 first

Feb 2027Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 · Phase 3 · Emory University
Dec 2026Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal · University of Calgary
Oct 2027Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS) · Etablissement Public de Santé Barthélemy Durand

Who these studies take

Of the 5 Substance Withdrawal Syndrome studies recruiting now, 0 (0%) set no upper age limit and 3 (60%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (20%) take healthy volunteers.

Recruiting studies that take each age, of 5
Age	Women	Men
10	0 (0%)	0 (0%)
18	4 (80%)	4 (80%)
30	5 (100%)	5 (100%)
40	5 (100%)	5 (100%)
50	5 (100%)	5 (100%)
65	4 (80%)	4 (80%)
75	3 (60%)	3 (60%)
85	1 (20%)	1 (20%)

Across all 74 studies, recruiting or not: 57% stop at 75 or younger and 51% at 65; 23% take children; 0% are for women only and 3% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 50 of 74. Browse all 74 → or search them.