Opioid-Induced Constipation clinical trials

The registry lists 87 studies for Opioid-Induced Constipation across more than 10 countries. 6 are recruiting or about to start. 74 of them are mainly about Opioid-Induced Constipation (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-05.

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Status

Completed: 63
Terminated: 10
Status unknown: 6
Recruiting: 5
Not yet recruiting: 1
Withdrawn: 1

Phase

Phase 3: 29
Phase 2: 24
Phase 4: 10
Phase 1: 6

Where

United States: 43
United Kingdom: 17
Germany: 12
Canada: 11
Spain: 11
Belgium: 11

Who runs them

Bausch Health Americas, Inc. (10) · AstraZeneca (10) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (7) · Glycyx Therapeutics (6) · Shionogi (6) · Sucampo Pharma Americas, LLC (4) · Kyowa Kirin Pharmaceutical Development Ltd (4) · Novartis (3)

What is being tested here

Drugs under test in Opioid-Induced Constipation studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Naldemedine	2	3	7
Magnesium Hydroxide	1	0	1
Naloxegol	0	7	12
Methylnaltrexone	0	5	10
Axelopran	0	0	6
Bevenopran	0	4	6
Lubiprostone	0	4	4
Naloxone	0	0	3
Tegaserod	0	3	3
Methylsamidorphan chloride	0	0	2

Drug classes tested here Opioid antagonists 25 · Serotonin receptor agonists 4

Coming up

0phase 3 studies under way

2studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 2

Jan 2027Prevention of Opioid-induced Constipation in Patients With Advanced Cancer · Amsterdam UMC, location VUmc
Mar 2027Naldemedine in Clinical Practice in Cancer Patients With Opioid Induced CONstipation: Clinical Outcomes and Patient Experience · Professor Monique A. H. Steegers

Who these studies take

Of the 5 Opioid-Induced Constipation studies recruiting now, 3 (60%) set no upper age limit and 2 (40%) stop at 75 or younger. 1 (20%) take children under 18. 0 (0%) are for women only and 1 (20%) for men only; 1 (20%) take healthy volunteers.

Recruiting studies that take each age, of 5
Age	Women	Men
10	1 (20%)	1 (20%)
18	4 (80%)	4 (80%)
30	3 (60%)	4 (80%)
40	3 (60%)	4 (80%)
50	3 (60%)	3 (60%)
65	3 (60%)	3 (60%)
75	3 (60%)	3 (60%)
85	3 (60%)	3 (60%)

Across all 87 studies, recruiting or not: 20% stop at 75 or younger and 15% at 65; 5% take children; 1% are for women only and 3% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 50 of 87. Browse all 87 → or search them.