Drug
N-Methyl-3,4-methylenedioxyamphetamine clinical trials
Also written MDMA.
- studies test it
- 89
- open now
- 22
- in phase 3
- 6
- first study started
- 2001
Keep track of what changes. Save the N-Methyl-3,4-methylenedioxyamphetamine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
89 studies that test it; most in 2025 (11)
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2006 | 1 |
| 2007 | 1 |
| 2009 | 3 |
| 2010 | 4 |
| 2011 | 4 |
| 2012 | 1 |
| 2013 | 5 |
| 2014 | 3 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 3 |
| 2018 | 4 |
| 2019 | 2 |
| 2020 | 2 |
| 2021 | 7 |
| 2022 | 7 |
| 2023 | 8 |
| 2024 | 7 |
| 2025 | 11 |
| 2026 | 9 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 10
- Phase 1
- 30
- Phase 2
- 39
- Phase 3
- 6
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 29 · Other 60
Lykos Therapeutics (24) · University Hospital, Basel, Switzerland (19) · University of Chicago (7) · Resilient Pharmaceuticals (2) · Emory University (2) · Yale University (2) · Johns Hopkins University (2) · Sunstone Medical (2)
Often tested with
Tested in the same studies.
Psilocybin (4) · Methylphenidate (4) · Lysergic Acid Diethylamide (3) · Methamphetamine (2) · Bean (1) · Tenamfetamine (1) · Carvedilol (1) · Doxazosin (1)
Studies
Open first, then newest update. How each study uses N-Methyl-3,4-methylenedioxyamphetamine is read from its arms, and is right about nine times in ten.
Testing it · 89
- MDMA in Borderline Personality DisorderRecruitingPhase 2Yale UniversityNCT06683014Written as MDMA
- Preliminary Effectiveness of Hybrid Individual and Group MDMA-assisted Therapy for War-related PTSDRecruitingPhase 2Guy SchusheimNCT05732155Written as methylenedioxymethamphetamine
- Dose Optimization of MDMA-Assisted Therapy for PTSDRecruitingPhase 2Bronx VA Medical CenterNCT06418178Written as Midomafetamine
- Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)RecruitingPhase 1Johns Hopkins UniversityNCT06989957Written as MDMA
- A Phase 2A Trial of DT402 for Autism Spectrum DisorderRecruitingPhase 2Definium Therapeutics US, Inc.NCT07303907Written as DT402 (R-enantiomer of 3,4-methylenedioxymethamphetamine (MDMA))
- MDMA-assisted Therapy for FibromyalgiaRecruitingEarly Phase 1Spaulding Rehabilitation HospitalNCT06066853Written as MDMA
- MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderRecruitingPhase 2Stephen Robert MarderNCT05790239Written as 3,4-methylenedioxymethamphetamine
- Ecstasy to Alleviate SEvere Chronic Neuropathic Pain TrialRecruitingPhase 2Unity Health TorontoNCT07301632Written as 3,4-Methylenedioxymethamphetamine
- Tolerability of MDMA in SchizophreniaRecruitingPhase 1/2Anya Bershad, MD, PhDNCT05770375Written as MDMA 40mg
- MDMA Plus Exposure Therapy for PTSDEnrolling by invitationPhase 2Emory UniversityNCT05746572Written as MDMA
- MDMA Therapy in Veterans With PTSDRecruitingPhase 2Sunstone MedicalNCT07569159Written as MDMA
- MDMA-Assisted Massed Exposure Therapy for PTSDRecruitingPhase 2Emory UniversityNCT07288151Written as 3,4-Methylenedioxymethamphetamine (MDMA)
- MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First RespondersNot yet recruitingPhase 2Nautilus SanctuaryNCT05455996Written as MDMA
- MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant OtherRecruitingPhase 2Sunstone MedicalNCT05584826Written as MDMA
- Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy ParticipantsRecruitingPhase 1University Hospital, Basel, SwitzerlandNCT07494214Written as MDMA 25 mg
- MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)RecruitingPhase 2Carolyn RodriguezNCT05783817Written as 3,4-Methyl enedioxy methamphetamine
- Investigation of Psychedelic Effects in Psychoactive SubstancesRecruitingPhase 1Johns Hopkins UniversityNCT06772753Written as Methylenedioxymethamphetamine (MDMA)
- MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderRecruitingPhase 2Patricia SuppesNCT05837845Written as MDMA
- The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy TrainingEnrolling by invitationNot applicableFelix MuellerNCT05570708Written as MDMA, LSD, psilocybin
- Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy ControlsRecruitingNot applicableUniversity Hospital, Basel, SwitzerlandNCT06789705Written as MDMA
See all 89 studies that test N-Methyl-3,4-methylenedioxyamphetamine →
As the comparator · 4 — what is tested is compared with N-Methyl-3,4-methylenedioxyamphetamine
- Dolutegravir-Lamivudine for naïve HIV-Infected Patients With ≤200 CD4/mm3CompletedPhase 4Fundación HuéspedNCT04880395Written as Comparator ARM: TDF/XTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine)
- Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy SubjectsCompletedPhase 1University Hospital, Basel, SwitzerlandNCT05523401Written as 3,4-methylenedioxymethamphetamine
- Abuse Potential and Human Pharmacology of MethyloneStatus unknownPhase 1Germans Trias i Pujol HospitalNCT05488171Written as 3,4-methylenedioxymethamphetamine
- Abuse Liability and Human Pharmacology of MephedroneCompletedPhase 1Parc de Salut MarNCT02232789Written as 3,4-methylenedioxymethamphetamine
Codes
What other systems call N-Methyl-3,4-methylenedioxyamphetamine · ClinicalTrials.gg INT008652
- MeSH (NLM) D018817N-Methyl-3,4-methylenedioxyamphetamineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) KE1SEN21RMMIDOMAFETAMINEConfirmed FDA, NLM
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D018817 | N-Methyl-3,4-methylenedioxyamphetamine | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | KE1SEN21RM | MIDOMAFETAMINE | Confirmed FDA, NLM |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.