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Opioid-Related Disorders clinical trials

The registry lists 1,473 studies for Opioid-Related Disorders across more than 10 countries. 290 are recruiting or about to start. 1,143 of them are mainly about Opioid-Related Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 2 narrower conditions too, such as Heroin Dependence: 1,558 studies, 296 open.

ClinicalTrials.gov finds 1,877 studies for Opioid-Related Disorders. How that becomes 1,472 here

This page counts the studies the registry files under Opioid-Related Disorders, and those it files under no condition that list Opioid-Related Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 1,877Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −84Filed under a narrower condition, counted on its own pageOpiate Overdose 46 · Heroin Dependence 37
  3. −2List Opioid-Related Disorders as a condition, but the registry did not file them under itMost often written as “Stimulant Use & Co-occuring Opioid Use Disorders” (1) and “Maternal Opioid Use Disorder” (1). The registry filed them under other conditions only, most often Substance-Related Disorders (1) and Neonatal Abstinence Syndrome (1).
  4. −319Match it another way24 name it in the title, 3 in a keyword, and 292 by a synonym or other text the search reads.
  5. 1,472The count on this page

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Status

Completed
890
Recruiting
209
Terminated
81
Active, not recruiting
77
Withdrawn
67
Status unknown
63

Phase

Phase 2
276
Phase 1
150
Phase 3
128
Phase 4
109
Early Phase 1
32

Where

United States
1,222
Canada
36
France
18
Sweden
13
China
12
Norway
12

Who runs them

Yale University (106) · National Institute on Drug Abuse (NIDA) (76) · New York State Psychiatric Institute (42) · Johns Hopkins University (41) · University of Pennsylvania (35) · Indivior Inc. (32) · University of California, Los Angeles (23) · NYU Langone Health (23)

What is being tested here

Drugs under test in Opioid-Related Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Buprenorphine1947173
Psilocybin509
Naloxone41153
Methadone4519
Cannabidiol4216
Morphine329
Sublocade2412
Ketamine219
Lidocaine215
Cannabis sativa subsp. indica TOP202

Drug classes tested here Opioids 27 open · Serotonin receptor agonists 6 open · Opioid antagonists 5 open · Local anesthetics 3 open · GLP-1 receptor agonists 3 open

Coming up

20phase 3 studies under way
140studies finish main data collection within a year9 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 209 Opioid-Related Disorders studies recruiting now, 122 (58%) set no upper age limit and 73 (35%) stop at 75 or younger. 14 (7%) take children under 18. 15 (7%) are for women only and 4 (2%) for men only; 52 (25%) take healthy volunteers.

Recruiting studies that take each age, of 209
AgeWomenMen
105 (2%)5 (2%)
18179 (86%)168 (80%)
30198 (95%)187 (89%)
40198 (95%)187 (89%)
50196 (94%)186 (89%)
65170 (81%)160 (77%)
75146 (70%)136 (65%)
85131 (63%)121 (58%)

Across all 1,473 studies, recruiting or not: 44% stop at 75 or younger and 39% at 65; 8% take children; 5% are for women only and 2% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Opioid-Related Disorders studies take

Of 77 phase 1 interventional studies under Opioid-Related Disorders, half reached primary completion within 19 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 119 mo9–33 · 77 studies—26 mo16–47 · 53 studies
Phase 1/228 mo21–37 · 14 studies——
Phase 240 mo23–55 · 68 studies—41 mo23–55 · 61 studies
Phase 2/352 mo35–85 · 18 studies——
Phase 342 mo18–56 · 31 studies——
Phase 432 mo20–55 · 52 studies—35 mo21–55 · 48 studies
Interventional, no phase29 mo13–46 · 495 studies14 mo7–24 · 31 studies29 mo14–47 · 464 studies
Observational27 mo13–47 · 88 studies—30 mo13–51 · 74 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting4

Results posted5

Stopped1

Newly registered8

Show 3 more

Studies

Recruiting first, then most recently updated. Showing 50 of 1,473. Browse all 1,473 → or search them.