Drug Overdose clinical trials
The registry lists 104 studies for Drug Overdose across more than 10 countries. 22 are recruiting or about to start. 57 of them are mainly about Drug Overdose (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Opiate Overdose too: 164 studies, 32 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Norwegian University of Science and Technology (6) · Kaiser Permanente (5) · NYU Langone Health (4) · Johns Hopkins Bloomberg School of Public Health (4) · San Francisco Department of Public Health (3) · Brown University (3) · University of Michigan (3) · University of Cincinnati (3)
What is being tested here
Drugs under test in Drug Overdose studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Naloxone | 0 | 0 | 8 |
| Buprenorphine | 0 | 0 | 2 |
| Charcoal | 0 | 0 | 1 |
| Glucagon | 0 | 0 | 1 |
| Esmolol | 0 | 0 | 1 |
| Metoprolol | 0 | 0 | 1 |
| Fat Emulsions, Intravenous | 0 | 0 | 1 |
| Ondansetron | 0 | 0 | 1 |
| Fomepizole | 0 | 0 | 1 |
| Nalmefene | 0 | 1 | 1 |
Drug classes tested here Opioid antagonists 9
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk · Boston Medical Center
- Dec 2026A Setting Focus Overdose Prevention Intervention · Johns Hopkins Bloomberg School of Public Health
- Dec 2026Overdose Prevention Centers and Behavioral Health · NYU Langone Health
- Mar 2027Shelter HArm Reduction Evaluation · NYU Langone Health
- May 2027Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk · April M Young
- Jun 2027The ENHANCE Project Toolkit · University of Wisconsin, Madison
- Jun 2027Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone) · RTI International
- Aug 2027A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose · Region Skane
- Nov 2027The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City · North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
Who these studies take
Of the 13 Drug Overdose studies recruiting now, 12 (92%) set no upper age limit and 1 (8%) stop at 75 or younger. 3 (23%) take children under 18. 1 (8%) are for women only and 0 (0%) for men only; 5 (38%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 1 (8%) |
| 18 | 12 (92%) | 11 (85%) |
| 30 | 12 (92%) | 11 (85%) |
| 40 | 12 (92%) | 11 (85%) |
| 50 | 12 (92%) | 11 (85%) |
| 65 | 12 (92%) | 11 (85%) |
| 75 | 12 (92%) | 11 (85%) |
| 85 | 12 (92%) | 11 (85%) |
Across all 104 studies, recruiting or not: 22% stop at 75 or younger and 22% at 65; 21% take children; 4% are for women only and 4% for men only; 36% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Drug Overdose studies take
Of 47 interventional studies with no phase under Drug Overdose, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 31 mo13–49 · 47 studies | — | 31 mo13–49 · 47 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3Nov 10, 2026NCT07797933
Newly registered1
- Disease Intervention Specialist (DIS) for SUDOct 15, 2026NCT07875361
Studies
Recruiting first, then most recently updated. Showing 50 of 104. Browse all 104 → or search them.
- A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3RecruitingNCT07797933Not applicable1 country
- HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex TraffickingNot yet recruitingNCT07264582Not applicable1 country
- Disease Intervention Specialist (DIS) for SUDNot yet recruitingNCT078753611 country
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- The ENHANCE Project ToolkitRecruitingNCT07649278Not applicable1 country
- The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services StudyNot yet recruitingNCT07216963Not applicable1 country
- Clinician Practice Companion to Address Youth Substance UseNot yet recruitingNCT07725289Not applicable2 countries
- Kentucky Women's Justice Community Overdose Innovation Network - Phase IIRecruitingNCT07179614Not applicable1 country
- Shelter HArm Reduction EvaluationRecruitingNCT071700721 country
- Behavioral Safety and Fentanyl Education: BSAFERecruitingNCT07219082Not applicable1 country
- Trauma-informed Intervention to Reduce Substance Use and to Support Community TransitionEnrolling by invitationNCT06651528Not applicable1 country
- A Setting Focus Overdose Prevention InterventionRecruitingNCT05320835Not applicable1 country
- Permanent Supportive Housing Overdose Prevention+ StudyNot yet recruitingNCT07214519Not applicable1 country
- Justice Community Overdose Innovation Network II TCU HubNot yet recruitingNCT07528846Not applicable1 country
- Social Network Overdose Prevention and Education InterventionRecruitingNCT06327061Not applicable1 country
- Overdose Prevention Centers and Behavioral HealthNot yet recruitingNCT062360871 country
- A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid OverdoseRecruitingNCT07079241Not applicable1 country
- Emergency Medicine Peer Outreach Worker Engagement for RecoveryRecruitingNCT063200151 country
- Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin PoisoningRecruitingNCT071930691 country
- Families Left BehindRecruitingNCT06854757Not applicable1 country
- 25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or DeathRecruitingNCT059440551 country
- Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming PopulationNot yet recruitingNCT055830581 country
- A Universal Primary Care Based Intervention to Reduce Youth Overdose RiskActive, not recruitingNCT07022717Not applicable1 country
- Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone)Active, not recruitingNCT05886712Not applicable1 country
- Home Safety InterventionCompletedNCT06216327Not applicable1 country
- Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose RiskActive, not recruitingNCT05657106Not applicable1 country
- HEALing Communities StudyCompletedNCT04111939Not applicable1 country
- The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York CityActive, not recruitingNCT06316739Not applicable1 country
- Pilot of Training on 988 and NarcanCompletedNCT07072819Not applicable1 country
- Community-based Education, Navigation, and Support Intervention for Military VeteransActive, not recruitingNCT05343169Not applicable1 country
- Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement StudyCompletedNCT05977881Not applicable1 country
- Permanent Supportive Housing Overdose PreventionActive, not recruitingNCT05786222Not applicable1 country
- Preventing Overdose Using Information and Data From the EnvironmentCompletedNCT05096429Not applicable1 country
- Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce OverdoseActive, not recruitingNCT06855836Not applicable1 country
- Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)CompletedNCT05776823Not applicable1 country
- More Individualized Care: Assessment and Recovery Through EngagementCompletedNCT05122676Not applicable1 country
- Mobile Peer Support for OUD RecoveryActive, not recruitingNCT05405712Not applicable1 country
- Mental Health Associations With VitiligoCompletedNCT049533381 country
- Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen OverdoseTerminatedNCT05517668Phase 21 country
- Stimulant Overdose in the Medicaid Population: Who is at Risk, and When Are They at RiskCompletedNCT059769841 country
- The Rhode Island Prescription and Illicit Drug StudyCompletedNCT04372238Not applicable1 country
- Repeated-dose Behavioral Intervention to Reduce Opioid OverdoseCompletedNCT03838510Not applicable1 country
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid OverdoseWithdrawnNCT06408714Phase 31 country
- Peer Intervention to Link Overdose Survivors to Treatment (PILOT)CompletedNCT05123027Not applicable1 country
- Smartphone Intervention for Overdose and COVID-19CompletedNCT05518461Not applicable1 country
- FAVOR Opioid Recovery Coaching EvaluationCompletedNCT03798470Not applicable1 country
- Rapid Initiation of Drug Treatment EngagementCompletedNCT03908437Phase 41 country
- Emergency Room Firearm and Medication Safety InterventionCompletedNCT047972211 country
- Evaluation of a Medication Health Center to Promote Opioid SafetyActive, not recruitingNCT06456294Not applicable1 country
- Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting EfficacyCompletedNCT06219967Phase 41 country