Phantom Limb clinical trials
The registry lists 163 studies for Phantom Limb across more than 10 countries. 35 are recruiting or about to start. 129 of them are mainly about Phantom Limb (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
University of California, San Diego (9) · VA Office of Research and Development (4) · The University of Texas Health Science Center, Houston (3) · Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) (3) · Spaulding Rehabilitation Hospital (3) · Ukrainian Society of Regional Anesthesia and Pain Therapy (3) · Lee Fisher, PhD (3) · Skolkovo Institute of Science and Technology (3)
What is being tested here
Drugs under test in Phantom Limb studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lidocaine | 1 | 0 | 2 |
| Adezunap | 1 | 1 | 1 |
| Pregabalin | 0 | 1 | 2 |
| Psilocybin | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
| Valproic Acid | 0 | 0 | 1 |
| rimabotulinumtoxinB | 0 | 0 | 1 |
| Nabilone | 0 | 0 | 1 |
| Morphine | 0 | 0 | 1 |
| Mexiletine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Dec 2026Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved. · Phase 3 · The Ketamine Research Foundation
- Nov 2026Amputations in Childhood and Neuropathic Pain · Hopitaux de Saint-Maurice
- Dec 2026Early Postoperative Pain Following a Limb Amputation · Istituto Ortopedico Rizzoli
- Dec 2026A Study of Contralateral Limb Block · Mayo Clinic
- Dec 2026TITAN Trial: Reducing Phantom Limb Pain in People with Amputations · Neuroscience Research Australia
- Dec 2026Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA) · Winfried Meißner
- Jun 2027Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment Response · Spaulding Rehabilitation Hospital
- Sep 2027Feasibility of Neural Feedback for Lower Limb Amputees · Louis Stokes VA Medical Center
- Sep 2027Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation · Skolkovo Institute of Science and Technology
- Nov 2027Pain and Disability Outcomes in Post Amputation Patients · Milton S. Hershey Medical Center
Who these studies take
Of the 25 Phantom Limb studies recruiting now, 13 (52%) set no upper age limit and 8 (32%) stop at 75 or younger. 1 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 25 (100%) | 25 (100%) |
| 30 | 24 (96%) | 24 (96%) |
| 40 | 24 (96%) | 24 (96%) |
| 50 | 24 (96%) | 24 (96%) |
| 65 | 24 (96%) | 24 (96%) |
| 75 | 18 (72%) | 18 (72%) |
| 85 | 17 (68%) | 17 (68%) |
Across all 163 studies, recruiting or not: 34% stop at 75 or younger and 18% at 65; 8% take children; 0% are for women only and 1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Phantom Limb studies take
Of 64 interventional studies with no phase under Phantom Limb, half reached primary completion within 34 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 34 mo13–50 · 64 studies | — | 32 mo12–47 · 61 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 163. Browse all 163 → or search them.
- Early Postoperative Pain Following a Limb AmputationRecruitingNCT073931391 country
- Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb AmputationsRecruitingNCT06106984Not applicable1 country
- Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy PatientsRecruitingNCT060942571 country
- Training Independent Muscle Activation From a Common SourceRecruitingNCT07831278Not applicable1 country
- Alcohol Neurolysis and Capsaicin for Postamputation Pain (PAP)Not yet recruitingNCT07443553Not applicable1 country
- AMI Construction in Lower Extremity Residual LimbsRecruitingNCT04063592Not applicable1 country
- Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort StudyNot yet recruitingNCT07438795
- Pain and Disability Outcomes in Post Amputation PatientsRecruitingNCT057163211 country
- Prophylactic TBR on Phantom Limb PainEnrolling by invitationNCT06956508Not applicable1 country
- Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved.RecruitingNCT07276542Phase 2/31 country
- Feasibility of Neural Feedback for Lower Limb AmputeesRecruitingNCT03409133Not applicable1 country
- Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic InjectionNot yet recruitingNCT07431944Not applicable1 country
- Amputations in Childhood and Neuropathic PainRecruitingNCT074019661 country
- Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis SystemRecruitingNCT07324109Not applicable1 country
- A Study of Contralateral Limb BlockRecruitingNCT06045936Phase 41 country
- Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment ResponseRecruitingNCT05188183Not applicable1 country
- Prevention of PostAmputation Pain With Targeted Muscle ReinnervationRecruitingNCT06719245Not applicable1 country
- Novel Non-invasive Brain Stimulation Techniques in Neurological RehabilitationRecruitingNCT05766059Not applicable1 country
- Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCSRecruitingNCT07139483Not applicable1 country
- Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based TreatmentRecruitingNCT07044323Not applicable1 country
- Treatment of Phantom Limb Pain by Intensive Visual Simulation TherapyRecruitingNCT06483035Not applicable1 country
- Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb AmputationRecruitingNCT06813937Not applicable1 country
- Surgical Treatments for Postamputation PainRecruitingNCT05009394Not applicable7 countries
- TITAN Trial: Reducing Phantom Limb Pain in People with AmputationsRecruitingNCT06167330Not applicable1 country
- Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of LifeRecruitingNCT06702904Not applicable1 country
- Quest to Analyze One Thousand Humans MeditatingEnrolling by invitationNCT065833951 country
- Study of Phantom Limb Pain Suppression Using Neuromodulation MethodsRecruitingNCT06644807Not applicable1 country
- Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)Not yet recruitingNCT066045071 country
- Clinical Evaluation of the Medical Device (MD) (Caloprothese Connected Kit, CCK)RecruitingNCT04748484Not applicable1 country
- Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any GenesisRecruitingNCT06071949Phase 31 country
- Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any GenesisRecruitingNCT06072001Phase 31 country
- Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord StimulationEnrolling by invitationNCT05807607Not applicable1 country
- Study of Phantom Limb Pain Using Peripheral Nerve and Spinal Cord StimulationEnrolling by invitationNCT05650931Not applicable1 country
- Continuous Sciatic Nerve Block vs Epidural Analgesia in Lower Limb Amputation for Postoperative PainNot yet recruitingNCT05608733Phase 31 country
- Neural Bases of Phantom Pain After AmputationNot yet recruitingNCT05545358
- Immersive Healing: The Therapeutic Potential of Virtual RealityCompletedNCT06077227Not applicable1 country
- Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related AmputationCompletedNCT07626983Not applicable1 country
- Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related AmputationCompletedNCT07618689Not applicable1 country
- Tourniquet Exposure and Risk of Chronic Pain After Severe Limb TraumaCompletedNCT074758711 country
- Intrathecal Dexmedetomidine and Acute Neuropathic Pain After Lower Limb AmputationCompletedNCT07565662Not applicable1 country
- Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity TraumaCompletedNCT074326851 country
- Psilocybin-assisted Therapy for Phantom Limb PainActive, not recruitingNCT05224336Phase 11 country
- Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg PainCompletedNCT05296265Not applicable1 country
- Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter StudyCompletedNCT03461120Phase 41 country
- Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic PainCompletedNCT03029884Not applicable1 country
- Targeted Muscle Reinnervation Study (TMR)WithdrawnNCT05408520Not applicable1 country
- Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee AmputationCompletedNCT06071715Not applicable1 country
- Assessing the Feasibility of a Virtual Reality Intervention for Phantom Pain Immediately Following Lower Limb AmputationCompletedNCT066389181 country
- Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb AmputationCompletedNCT05880251Not applicable1 country
- Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-DayTerminatedNCT04547582Not applicable1 country