Drug
Valproic Acid clinical trials
Also written Divalproex Sodium, Depakote and Depakene.
- studies test it
- 264
- open now
- 17
- in phase 3
- 47
- first study started
- 1991
Keep track of what changes. Save the Valproic Acid studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Other names
Studies by the year they started
261 studies that test it; most in 2004 (30); 1 more planned to start later
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1997 | 3 |
| 1999 | 1 |
| 2000 | 4 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 25 |
| 2004 | 30 |
| 2005 | 21 |
| 2006 | 29 |
| 2007 | 13 |
| 2008 | 10 |
| 2009 | 9 |
| 2010 | 9 |
| 2011 | 12 |
| 2012 | 8 |
| 2013 | 10 |
| 2014 | 5 |
| 2015 | 11 |
| 2016 | 9 |
| 2017 | 7 |
| 2018 | 8 |
| 2019 | 4 |
| 2021 | 4 |
| 2022 | 6 |
| 2023 | 11 |
| 2024 | 4 |
| 2025 | 1 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 5
- Phase 1
- 78
- Phase 2
- 88
- Phase 3
- 47
- Phase 4
- 54
- No phase
- 17
What it is tested for
Each study’s main condition, where its own words name it.
- Epilepsy
- 14
Who runs them
Industry 48 · Other 216
M.D. Anderson Cancer Center (11) · Abbott (10) · Dr. Reddy's Laboratories Limited (7) · University of Utah (5) · National Cancer Institute, Naples (5) · Sanofi (4) · National Cancer Institute (NCI) (4) · Teva Pharmaceuticals USA (4)
Often tested with
Tested in the same studies.
Lithium (14) · Lamotrigine (10) · Risperidone (9) · Quetiapine (9) · Levetiracetam (8) · Carbamazepine (6) · Topiramate (6) · Azacitidine (6)
Studies
Open first, then newest update. How each study uses Valproic Acid is read from its arms, and is right about nine times in ten.
Testing it · 264
- VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingPhase 2Inova Health Care ServicesNCT07831369Written as Valproic Acid (VPA)
- Seizure Treatment in GliomaRecruitingPhase 4Leiden University Medical CenterNCT03048084Written as Valproic Acid
- Valproic AcId for Traumatic BRAin INjury TrialNot yet recruitingPhase 2/3Northwestern UniversityNCT07166393Written as Valproic Acid (VPA)
- Valproate for the Treatment of Residual AmblyopiaRecruitingPhase 1/2Boston Children's HospitalNCT07226141Written as Valproate
- Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma PatientsRecruitingPhase 2National Cancer Institute, NaplesNCT05821556Written as Valproic acid
- ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal CancerRecruitingPhase 2National Cancer Institute, NaplesNCT06714357Written as Valproic Acid (VPA)
- Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing StrategyRecruitingPhase 2/3M.D. Anderson Cancer CenterNCT05431595Written as Valproate
- Pharmacogenetics-Based Study on Individualized Use of Sodium ValproateRecruitingPhase 4The First Affiliated Hospital of University of South ChinaNCT07046676Written as sodium valproate
- A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS PatientsRecruitingPhase 1/2Haukeland University HospitalNCT06199557Written as Valproic acid
- Valproate Versus Propranolol in MigraineRecruitingPhase 4Kafrelsheikh UniversityNCT06485726Written as Valproic Acid 500 MG
- An International Clinical Program for the Diagnosis and Treatment of Children With EpendymomaRecruitingPhase 2/3Centre Leon BerardNCT02265770Written as Chemotherapy + Valproate
- Combination Regimen With Sodium Valproate for Severe Hemophilia: a Single-arm, Phase 1, Pilot Trial.RecruitingPhase 1/2Xue-chun LuNCT05920512Written as Sodium valproate extended-release tablets
- Sodium Valproate in Patients With Acute Ischemic StrokeRecruitingPhase 2RenJi HospitalNCT06020898Written as Sodium valproate
- Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram SyndromeRecruitingPhase 2Centre d'Etude des Cellules SouchesNCT04940572Written as Depakine
- Zolmitriptane as Prophylaxis for Chilhood MigraineRecruitingPhase 4Tanta UniversityNCT06089356Written as Valproate
- Repurposed Drugs to Improve Haematological Responses in Myelodysplastic SyndromesRecruitingPhase 2Prof. Janet DunnNCT04997811Written as Sodium Valproate, Bezafibrate, Medroxyprogesterone
- Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of RecurrenceRecruitingEarly Phase 1Miller Children's & Women's Hospital Long BeachNCT02446431Written as Valproic Acid
- Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal MelanomaActive, not recruitingPhase 2Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityNCT02068586Written as Valproic Acid
- Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated CaSuspendedPhase 1/2Virginia Commonwealth UniversityNCT03919292Written as Divalproex Sodium
- Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy (Depakine)CompletedPhase 2Nantes University HospitalNCT00385710Written as valproic acid
See all 264 studies that test Valproic Acid →
Given in every arm · 18 — Valproic Acid is usual care beside what is tested
- A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)RecruitingPhase 3Bristol-Myers SquibbNCT06929273Written as Valproate
- Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory StudyNot yet recruitingPhase 4Assiut UniversityNCT05881928Written as Sodium Valproate 500 Mg Prolonged-Release Oral Tablet
- ABLE: Abilify in Bipolar Disorder for Long-term EffectivenessCompletedPhase 4Korea Otsuka International Asia ArabNCT00484471Written as valproate
- Gabapentin for Alcohol Withdrawal SyndromeCompletedPhase 4Mayo ClinicNCT03012815Written as Divalproex Sodium
- Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active MetaboliteCompletedPhase 1Emalex Biosciences Inc.NCT04902105Written as Divalproex Sodium ER
- Safety and Efficacy Study of ELND005 as an Adjunctive Maintenance Treatment in Bipolar I DisorderTerminatedPhase 2OPKO Health, Inc.NCT01674010Written as Valproic acid
- Treatment of Mania Symptoms With Drug TherapyCompletedPhase 3Palo Alto Veterans Institute for ResearchNCT00183443Written as Divalproex-extended release (DVP-ER)
- A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell OriginCompletedPhase 2National Cancer Institute (NCI)NCT01182285Written as Valproic Acid
- Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/LymphomaTerminatedPhase 4University of MiamiNCT00854581Written as Valproic Acid
- Combination Therapy for the Treatment of Bipolar DisordersTerminatedPhase 3University Hospitals Cleveland Medical CenterNCT00063362Written as Divalproex
- Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic EpisodeCompletedPhase 3University of British ColumbiaNCT01977300Written as Valproate
- Combination Therapy in Dual Diagnosis Bipolar Rapid CyclingCompletedPhase 3University Hospitals Cleveland Medical CenterNCT00221975Written as Divalproex
- Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I DisorderCompletedPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT00665366Written as Valproate
- Add-on Dextromethorphan in Bipolar DisordersCompletedPhase 3National Cheng-Kung University HospitalNCT01188265Written as Valproate
- Valproic Acid-Based 2-Agent Oral Regimens for Patients With Advanced Solid TumorCompletedPhase 1M.D. Anderson Cancer CenterNCT00495872Written as Valproic Acid
- Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)Status unknownPhase 4Joseph BladerNCT00794625Written as Valproate
- Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I DisorderCompletedPhase 3Eli Lilly and CompanyNCT00266630Written as valproate
- A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar PatientsCompletedPhase 4Eli Lilly and CompanyNCT00402324Written as divalproex
As the comparator · 6 — what is tested is compared with Valproic Acid
- Vortioxetine Adjunctive Treatment in Bipolar DepressionCompletedPhase 4First Affiliated Hospital of Zhejiang UniversityNCT05481957Written as valprote
- Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic SeizuresCompletedPhase 4Mazandaran University of Medical SciencesNCT03940326Written as Valproate
- Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status EpilepticusCompletedPhase 2Banaras Hindu UniversityNCT02920060Written as Sodium valproate
- Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed EpilepsyCompletedPhase 3UCB PharmaNCT00175903Written as Valproate Extended Release
- Efficacy of Combined Treatment for Young Bipolar I DisorderCompletedPhase 4University of Sao PauloNCT00976794Written as lithium plus valproate
- To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.Status unknownNot applicableShanghai Jiao Tong University School of MedicineNCT00742638Written as Sodium valproate
Codes
What other systems call Valproic Acid · ClinicalTrials.gg INT008394
- MeSH (NLM) D014635Valproic AcidConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 614OI1Z5WIVALPROIC ACIDConfirmed FDA, NLM, Wikidata
- RxNorm 11118Confirmed FDA, Wikidata
- Wikidata Q240642valproic acidConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29536Valproic AcidOne source FDA
- DrugBank DB00313One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D014635 | Valproic Acid | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 614OI1Z5WI | VALPROIC ACID | Confirmed FDA, NLM, Wikidata |
| RxNorm | 11118 | — | Confirmed FDA, Wikidata |
| Wikidata | Q240642 | valproic acid | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29536 | Valproic Acid | One source FDA |
| DrugBank | DB00313 | — | One source Wikidata |
Also registered as divalproex sodium (UNII 644VL95AO6 · RxNorm 266856), valproate calcium (UNII 56CCK4F86G · RxNorm 1927), valproate magnesium (UNII Q400352CM2 · RxNorm 134422) and valproate sodium (UNII 5VOM6GYJ0D · RxNorm 9919).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.