Cardiotoxicity clinical trials
The registry lists 262 studies for Cardiotoxicity across more than 10 countries. 75 are recruiting or about to start. 116 of them are mainly about Cardiotoxicity (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Abramson Cancer Center at Penn Medicine (10) · Memorial Sloan Kettering Cancer Center (5) · University College, London (5) · Children's Oncology Group (5) · Groupe Hospitalier Pitie-Salpetriere (5) · Ain Shams University (4) · Peking University Third Hospital (4) · Washington University School of Medicine (4)
What is being tested here
Drugs under test in Cardiotoxicity studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Carvedilol | 2 | 3 | 7 |
| Dexrazoxane | 2 | 4 | 7 |
| Doxorubicin | 1 | 1 | 5 |
| Atorvastatin | 1 | 1 | 4 |
| Dapagliflozin | 1 | 0 | 2 |
| Spironolactone | 1 | 0 | 2 |
| Sacubitril valsartan | 1 | 0 | 2 |
| Vincristine | 1 | 0 | 1 |
| Polatuzumab vedotin | 1 | 0 | 1 |
| Nicorandil | 1 | 0 | 1 |
Drug classes tested here Beta blockers 2 open · SGLT2 inhibitors 2 open · Statins 2 open · ACE inhibitors 1 open · Antimitotic agents 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026The Use of Shengmai San to Prevent Anthracycline Sequential Trastuzumab Therapy Related Cardiac Toxicity · Phase 3 · Zhejiang Cancer Hospital
- Nov 2026Effects of Immune Checkpoint Inhibitors on Coronary Microvasculature · Abramson Cancer Center at Penn Medicine
- Dec 2026Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy · Abramson Cancer Center at Penn Medicine
- Dec 2026Role of Sodium-glucose Linked Transporter 2 (SGLT2) and Its Inhibitor Over CARdiotoxicity Induced by Anthracyclines and Breast Cancer Tumorigenesis SCARA-B · Centre Paul Strauss
- Dec 2026Early Assessment of Cardiac Function After Treatment With CAR-T Cells · Assistance Publique - Hôpitaux de Paris
- Dec 2026Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study · University of Alberta
- Dec 2026TRUST-ACE - Anticancer-treatment Cardiotoxicity Identification by Echocardiography · Norwegian University of Science and Technology
- Dec 2026Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity · West China Second University Hospital
- Dec 2026Early Prediction and Warning for Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy · First Hospital of China Medical University
- Jan 2027Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who these studies take
Of the 51 Cardiotoxicity studies recruiting now, 38 (75%) set no upper age limit and 8 (16%) stop at 75 or younger. 7 (14%) take children under 18. 15 (29%) are for women only and 0 (0%) for men only; 3 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (10%) | 4 (8%) |
| 18 | 47 (92%) | 33 (65%) |
| 30 | 47 (92%) | 33 (65%) |
| 40 | 46 (90%) | 32 (63%) |
| 50 | 45 (88%) | 31 (61%) |
| 65 | 47 (92%) | 32 (63%) |
| 75 | 44 (86%) | 30 (59%) |
| 85 | 41 (80%) | 29 (57%) |
Across all 262 studies, recruiting or not: 25% stop at 75 or younger and 15% at 65; 15% take children; 29% are for women only and 2% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cardiotoxicity studies take
Of 71 observational studies under Cardiotoxicity, half reached primary completion within 69 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 52 mo35–73 · 48 studies | — | 52 mo35–73 · 48 studies |
| Observational | 69 mo33–122 · 71 studies | — | 69 mo33–122 · 69 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 262. Browse all 262 → or search them.
- Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)RecruitingNCT07761910Phase 21 country
- The CARDIOPROTECT TrialNot yet recruitingNCT07654426Phase 21 country
- 3D Versus 2D Strain Echocardiography for Early Detection of Cardiotoxicity During Cancer TherapyRecruitingNCT079163371 country
- The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced CardiotoxicityNot yet recruitingNCT07897409Phase 21 country
- PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility StudyNot yet recruitingNCT053773201 country
- Monitoring for CardioToxicity Using WeArable deVices While Undergoing cancEr Treatments (MCT-WAVE)Not yet recruitingNCT07776964Not applicable1 country
- S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac ToxicityRecruitingNCT03418961Phase 34 countries
- Heart Failure in Women: Epidemiological and Prognostic InsightsRecruitingNCT078479831 country
- Cardioprotection Effect of LinagliptinNot yet recruitingNCT07852546Phase 31 country
- Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI)Not yet recruitingNCT078647271 country
- Hypertension and Arrhythmias in CLL Patients Treated With BTK InhibitorsEnrolling by invitationNCT062114131 country
- Novel On-body Evaluation of Cardiac Health for OncologyEnrolling by invitationNCT071584501 country
- Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.RecruitingNCT071576701 country
- Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced CardiotoxicityNot yet recruitingNCT07838649Phase 11 country
- Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell LymphomaRecruitingNCT06220032Phase 31 country
- Cardiac Side Effects of Systemic Therapy in Early-Stage Breast CancerRecruitingNCT075884251 country
- Reporting, Evaluating, Preventing and Treating the Cardiotoxicity Induced by Anticancer Drugs During a Specific Cardio-oncology Consult and Follow up in Routine CareRecruitingNCT038825801 country
- TRUST-ACE - Anticancer-treatment Cardiotoxicity Identification by EchocardiographyRecruitingNCT06310330Not applicable1 country
- The STOP-MED CTRCD TrialRecruitingNCT06183437Phase 46 countries
- Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac DysfunctionRecruitingNCT03934905Phase 1/21 country
- Development of a Pharmacogenomic Panel for Early Detection of Chemotherapy- and Immunotherapy-Induced Cardiotoxicity.RecruitingNCT076633571 country
- JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First YearRecruitingNCT06930521Not applicable1 country
- Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer PatientsRecruitingNCT027723671 country
- AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable MonitorRecruitingNCT066990561 country
- Cardiac Dysfunction in Childhood Cancer SurvivorsRecruitingNCT037909431 country
- A Study of Blood Pressure Control During Cancer TreatmentRecruitingNCT06023576Phase 21 country
- Global Cardio Oncology RegistryRecruitingNCT055988791 country
- Sotagliflozin as Prevention of Anthracycline-Related CardiotoxicityNot yet recruitingNCT07572175Phase 21 country
- Serial Cardiac Magnetic Resonance Imaging (CMR) With Contrast Agents and Biomarker Analysis for the Detection of Cardiotoxicity Under Anthracycline-containing Cancer TherapyRecruitingNCT07528586Not applicable1 country
- ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted TherapiesRecruitingNCT071917301 country
- Artificial Intelligence for Reconstruction of Echocardiography StudiesNot yet recruitingNCT07093918
- Role of Sodium-glucose Linked Transporter 2 (SGLT2) and Its Inhibitor Over CARdiotoxicity Induced by Anthracyclines and Breast Cancer Tumorigenesis SCARA-BRecruitingNCT064436451 country
- Early Identification of Cardivascular Damage Induced by Chemotherapy and Antineoplastic Treatments in Pediatric AgeRecruitingNCT07382141Not applicable1 country
- Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER StudyRecruitingNCT06595147Not applicable1 country
- BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEARTRecruitingNCT072998121 country
- Rosuvastatin for Prevention of Anthracycline-induced Cardiac Dysfunction in Breast Cancer PatientsNot yet recruitingNCT07254221Phase 41 country
- Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With AnthracyclineNot yet recruitingNCT072530771 country
- The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled TrialRecruitingNCT05023785Not applicable1 country
- Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 TargetedRecruitingNCT05559164Phase 21 country
- CARDiac Toxicity Following ImmunOtherapy Treatment for MelanomaEnrolling by invitationNCT066058331 country
- Early Assessment of Cardiac Function After Treatment With CAR-T CellsRecruitingNCT063509941 country
- Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related CardiotoxicityRecruitingNCT061329841 country
- Radiation-induced Toxicity of the HeartNot yet recruitingNCT06986291Not applicable1 country
- Optimizing Radiation Dose and Utilizing Wearable Devices to Reduce Arrhythmia Risk in Patients Undergoing Thoracic Radiotherapy: A Prospective Cohort StudyNot yet recruitingNCT068971891 country
- Determinants of Physical Activity Level in Pediatric Oncological Patients Treated With Cardiotoxic Therapy - a Study ProtocolNot yet recruitingNCT06256068
- Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)RecruitingNCT03711110Not applicable1 country
- Cardiac Rehabilitation Program on the Prevention of Cardiotoxicity in Breast Cancer Patients Undergoing Treatment With Anthracyclines and/or TrastuzumabNot yet recruitingNCT06881940Not applicable1 country
- Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)RecruitingNCT05465031Phase 41 country
- Cardiovascular Health in Adult Patients With Cancer Exposed to Cardiotoxic TherapiesRecruitingNCT066645281 country
- Cardioprotection on Chemotherapy-Induced CardiotoxicityRecruitingNCT06853951Phase 31 country