Massachusetts General Hospital: Depression trials

The registry lists 171 Depression studies with Massachusetts General Hospital as lead sponsor. 25 are open to participants now and 74 have results posted.

Phase 1 2Phase 2 21Phase 3 8Phase 4 27No phase 114(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Effect of Neurofeedback and TMSNot yet recruitingNCT07892287Not applicable
• The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar DepressionRecruitingNCT07699445Phase 4
• Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing FacilitiesRecruitingNCT07655232Not applicable
• A Study of a Mental Fitness Intervention for Anesthesiology Resident Wellbeing and Self-CompassionNot yet recruitingNCT07639827Not applicable
• Stress Management and Meditative Movements for Asian Americans With Depression and Physical SymptomsRecruitingNCT07610928Not applicable
• Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant DepressionRecruitingNCT07563868Not applicable
• Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical TrialNot yet recruitingNCT07460063Not applicable
• Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and HospitalRecruitingNCT07359157Not applicable
• Behavioral Health Program for Short-Stay Nursing Facility Residents & Care PartnersRecruitingNCT07220486Not applicable
• Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus StudyRecruitingNCT07118722Not applicable
• Building ConnectionsRecruitingNCT07091032Not applicable
• Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for DepressionRecruitingNCT07082998Not applicable
• Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who SmokeRecruitingNCT06654414Not applicable
• Cannabis, Linked Emotions, and Adolescent Risk StudyRecruitingNCT06576076Not applicable
• Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic ConditionsRecruitingNCT06557005Not applicable
• Change My Story Task Shifted Mental Health InterventionRecruitingNCT06389565Not applicable
• Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in ZimbabweRecruitingNCT06226155Not applicable
• Intervention Development for Syndemics Among PWH in SANot yet recruitingNCT06152003Not applicable
• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via InfliximabRecruitingNCT06136546Phase 2
• Adapting the Tumor Board Model for Mental Illness and CancerRecruitingNCT05837598Not applicable
• Training in Evidence-based Treatments in Psycho-OncologyRecruitingNCT05674357Not applicable
• Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIVRecruitingNCT05570812Phase 2
• Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionRecruitingNCT05450432Phase 4
• Buspirone and Melatonin for Depression Following Traumatic Brain InjuryRecruitingNCT04400266Phase 4
• Sensor-based Characterization of DepressionRecruitingNCT04370002
• Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open PilotCompletedNCT07336342Not applicableResults posted
• Fluoxetine Treatment of Depression in Down SyndromeCompletedNCT05458479Phase 4Results posted
• MBCT Via Group Videoconferencing for Acute Coronary Syndrome Patients With Depressive Symptoms: A Pilot RCTCompletedNCT04799899Not applicableResults posted
• Positive Minds Strong Bodies ImplementationCompletedNCT04545593Not applicableResults posted
• Examining Validity and Reliability of the Shared Decision Making Process Survey in Adults With DepressionCompletedNCT04343534Results posted
• PEERS Using Peer Mentors to Deliver Depression CareCompletedNCT04319094Not applicableResults posted
• MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive SymptomsCompletedNCT04231097Not applicableResults posted
• MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression SymptomsCompletedNCT03878160Not applicableResults posted
• Preventing Depressive Relapse in Pregnant Women With Recurrent DepressionCompletedNCT03623620Not applicableResults posted
• Healthy Hearts Healthy MindsCompletedNCT03373110Not applicableResults posted
• Bridge: Proactive Psychiatry Consultation and Case Management for Patients With CancerCompletedNCT03360695Not applicableResults posted
• Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use DisordersCompletedNCT03315208Not applicableResults posted
• Effect of Medical Marijuana on Neurocognition and Escalation of UseCompletedNCT03224468Not applicableResults posted
• A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)CompletedNCT03149991Phase 4Results posted
• Support for Perinatal Adherence and DepressionCompletedNCT03069417Not applicableResults posted
• Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of VortioxetineTerminatedNCT02969876Phase 4Results posted
• Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)CompletedNCT02959307Not applicableResults posted
• Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid AllopregnanoloneCompletedNCT02900092Not applicableResults posted
• EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early PregnancyCompletedNCT02676882Not applicableResults posted
• Physiological and Cognitive Biomarkers for Ketamine's Antidepressant EffectsTerminatedNCT02669043Not applicableResults posted
• Hyperthermic Yoga for Depressive SymptomsCompletedNCT02607514Not applicableResults posted
• Neurobiological Underpinnings of Placebo Response in DepressionCompletedNCT02562430Phase 4Results posted
• Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized ApproachCompletedNCT02553915Phase 2/3Results posted
• Ketamine for Depression: An MRI StudyCompletedNCT02544607Phase 4Results posted
• Preventing Postpartum Depression With Intranasal OxytocinCompletedNCT02505984Phase 2Results posted
• Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood MaltreatmentCompletedNCT02447744Not applicableResults posted
• Building Community Capacity for Disability Prevention for Minority Elders (Positive Minds - Strong Bodies)CompletedNCT02317432Not applicableResults posted
• Vortioxetine for Menopausal DepressionCompletedNCT02234362Phase 4Results posted
• The Effect of Questionnaire Content on Measures of Pain Intensity, Magnitude of Disability, and Symptoms of Depression in Patients With Arm IllnessCompletedNCT02209259Not applicableResults posted
• Investigation of Brain Network Dynamics in DepressionCompletedNCT01931995Not applicableResults posted
• Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)CompletedNCT01920555Phase 2Results posted
• Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant DepressionTerminatedNCT01913535Phase 2Results posted
• Low-Dose Naltrexone (LDN) for Depression Relapse and RecurrenceCompletedNCT01874951Phase 2Results posted
• Neurobiological Bases of Placebo Response in Major Depressive DisorderTerminatedNCT01787240Phase 4Results posted
• Adjunctive Isradipine for the Treatment of Bipolar DepressionTerminatedNCT01784666Phase 2Results posted
• Testosterone Antidepressant Augmentation in WomenCompletedNCT01783574Not applicableResults posted
• Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderCompletedNCT01667926Not applicableResults posted
• Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant DepressionCompletedNCT01654796Not applicableResults posted
• Ketamine Infusion for Treatment-resistant Major Depressive DisorderCompletedNCT01582945Not applicableResults posted
• Stimulant Enhancement of Well-Being Therapy for DepressionTerminatedNCT01478113Not applicableResults posted
• Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive DisorderTerminatedNCT01337609Phase 4Results posted
• Behavioral Medicine Intervention With Depressed Patients in a Community Health Center SettingCompletedNCT01330420Not applicableResults posted
• Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)CompletedNCT01325532Not applicableResults posted
• A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)TerminatedNCT01312844Phase 2Results posted
• N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionTerminatedNCT01260649Phase 4Results posted
• A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac PatientsCompletedNCT01201967Phase 4Results posted
• Duloxetine for Menopausal DepressionCompletedNCT01117857Phase 4Results posted
• Pilot Study of Open-label Placebo to Treat Major Depressive DisorderCompletedNCT01103271Phase 2Results posted
• Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic SymptomsTerminatedNCT00955474Phase 4Results posted
• A Collaborative Care Program to Improve Depression Treatment in Cardiac PatientsCompletedNCT00847132Not applicableResults posted
• Escitalopram (Lexapro) for the Treatment of Postpartum DepressionCompletedNCT00833469Phase 4Results posted
• Omega-3 for Peri- and Postmenopausal DepressionCompletedNCT00825994Not applicableResults posted
• Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in DepressionCompletedNCT00824044Phase 4Results posted
• Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)CompletedNCT00731653Phase 2Results posted
• Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)CompletedNCT00705003Phase 2Results posted
• A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant TherapyCompletedNCT00683852Phase 3Results posted
• Effects of Testosterone in Women With DepressionCompletedNCT00676676Not applicableResults posted
• Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIsCompletedNCT00633399Phase 2Results posted
• The Oral Contraceptive Pill for Premenstrual Worsening of DepressionCompletedNCT00633360Not applicableResults posted
• The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive FunctioningCompletedNCT00566735Phase 3Results posted
• CBT for Adherence and Depression in DiabetesCompletedNCT00564070Not applicableResults posted
• The Combination of Aripiprazole and Antidepressants in Psychotic Major DepressionCompletedNCT00556140Phase 3Results posted
• A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive DisorderCompletedNCT00555997Phase 2Results posted
• Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing HomeCompletedNCT00505518Not applicableResults posted
• Brain GABA Levels and Treatment Response in Major Depressive DisorderCompletedNCT00464711Phase 4Results posted
• Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and AlcoholismCompletedNCT00452543Phase 4Results posted
• Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal CancerTerminatedNCT00387348Phase 3Results posted
• Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major DepressionCompletedNCT00361374Phase 3Results posted
• Biological Markers of Response to Treatment in Major Depressive DisorderCompletedNCT00361218Phase 3Results posted
• Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1CompletedNCT00218634Not applicableResults posted
• A Study of Sertraline to Prevent PTSDCompletedNCT00182078Phase 4Results posted
• Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual DysfunctionCompletedNCT00181961Phase 3Results posted
• Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant DepressionCompletedNCT00093847Phase 2Results posted
• Drug Therapy to Treat Minor DepressionCompletedNCT00048815Not applicableResults posted
• Pilot Study of a Behavioral Program for Depression in Skilled Nursing Facility Residents and Care PartnersCompletedNCT07891546Not applicable