Drug
Pregnenolone clinical trials
Keep track of what changes. Save the Pregnenolone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
35 studies that test it; most in 2026 (5)
| Year | Studies |
|---|---|
| 2004 | 2 |
| 2005 | 2 |
| 2007 | 1 |
| 2008 | 1 |
| 2009 | 4 |
| 2010 | 2 |
| 2011 | 2 |
| 2013 | 3 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 1 |
| 2018 | 1 |
| 2019 | 3 |
| 2021 | 1 |
| 2023 | 1 |
| 2024 | 2 |
| 2025 | 1 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 0 · Other 35
VA Office of Research and Development (6) · University of Texas Southwestern Medical Center (6) · Durham VA Medical Center (3) · Sha'ar Menashe Mental Health Center (3) · Stanford University (2) · Sherwood Brown, MD, PhD (2) · Yale University (2) · Medical University of South Carolina (1)
Often tested with
Tested in the same studies.
Dehydroepiandrosterone (2) · Cytidine Diphosphate Choline (1) · Cannabis sativa subsp. indica TOP (1) · Theanine (1)
Studies
Open first, then newest update. How each study uses Pregnenolone is read from its arms, and is right about nine times in ten.
Testing it · 35
- A New Intervention to Improve Function in Veterans With Anxiety and DepressionRecruitingPhase 2VA Office of Research and DevelopmentNCT06188923Written as Pregnenolone
- Pregnenolone as a Treatment for Cannabis IntoxicationRecruitingPhase 2Johns Hopkins UniversityNCT07216690Written as Pregnenolone 250 mg
- Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II TrialNot yet recruitingPhase 2VA Office of Research and DevelopmentNCT05935761Written as Pregnenolone
- Study on Allopregnanolone and Depression in Women Across the Menopause TransitionRecruitingNot applicableBeth Israel Deaconess Medical CenterNCT06238700Written as pregnenolone
- Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive DisorderNot yet recruitingPhase 2Sherwood Brown, MD, PhDNCT07734701Written as Pregnenolone
- Pregnenolone for Cannabis Use Disorder and DepressionNot yet recruitingPhase 1/2University of Texas Southwestern Medical CenterNCT07685964Written as Pregnenolone
- Pregnenolone for the Treatment of Alcohol Use DisorderRecruitingPhase 2Yale UniversityNCT05781009Written as Pregnenolone
- Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIVRecruitingPhase 2Massachusetts General HospitalNCT05570812Written as Pregnenolone
- Neurosteroids for Treatment of PTSD in VeteransCompletedPhase 2VA Office of Research and DevelopmentNCT03799562Written as Pregnenolone
- Novel Intervention for Chronic Complex TBI in OEF/OIF/OND VeteransSuspendedPhase 2Christine Marx, MDNCT05671692Written as Pregnenolone
- Pilot Trial of Pregnenolone in AutismCompletedPhase 2Stanford UniversityNCT02627508Written as Pregnenolone
- A Neurosteroid Intervention for Menopausal and Perimenopausal DepressionCompletedPhase 1/2University of Texas Southwestern Medical CenterNCT03505905Written as Pregnenolone
- Clinical Medication Development for Bipolar Disorder and Alcohol Use DisordersCompletedPhase 4Sherwood Brown, MD, PhDNCT02582905Written as Pregnenolone
- The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use DisordersCompletedEarly Phase 1Yale UniversityNCT03953612Written as Pregnenolone (PREG)
- Effects of Pregnenolone on Perceived Social IsolationTerminatedPhase 2University of ChicagoNCT02826577Written as Pregnenolone 175mg
- Development of Pregnenolone as a Treatment for DepressionCompletedPhase 1University of Texas Southwestern Medical CenterNCT03645096Written as Pregnenolone 500 mg
- Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use DisorderWithdrawnPhase 1University of Texas Southwestern Medical CenterNCT04464148Written as Pregnenolone 250 mg
- Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI)CompletedPhase 2VA Office of Research and DevelopmentNCT01956279Written as Pregnenolone
- Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF VeteransCompletedPhase 2VA Office of Research and DevelopmentNCT01336413Written as Pregnenolone
- Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF VeteransCompletedPhase 2Durham VA Medical CenterNCT01898013Written as Pregnenolone
Codes
What other systems call Pregnenolone · ClinicalTrials.gg INT008086
- MeSH (NLM) D011284PregnenoloneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 73R90F7MQ8PREGNENOLONEConfirmed FDA, NLM, Wikidata
- RxNorm 114052Confirmed FDA, Wikidata
- Wikidata Q412158pregnenoloneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C82315PregnenoloneOne source FDA
- DrugBank DB02789One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011284 | Pregnenolone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 73R90F7MQ8 | PREGNENOLONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 114052 | — | Confirmed FDA, Wikidata |
| Wikidata | Q412158 | pregnenolone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C82315 | Pregnenolone | One source FDA |
| DrugBank | DB02789 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.