An interventional study of Interventions for Stressful Transitions in Later Life (InSTILL) in Nursing Home Resident, Skilled Nursing Facility and Depression, sponsored by Massachusetts General Hospital. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by Massachusetts General Hospital · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to test a behavioral health program (Interventions for Stressful Transitions in Later Life, InSTILL) for skilled nursing facility residents and care partners. The main questions it aims to answer is whether the program is program is feasible, satisfactory, and helpful. Participants will join 8 bi-weekly sessions of the InSTILL program. Participants will complete assessments at three timepoints (all) and a brief-exit interview.
8,245 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 14 is below the median of 84 across 6,869 interventional studies indexed under Depression.
Browse Depression studies →Massachusetts General Hospital is the lead sponsor of 2,582 studies on the registry; 451 are open to participants now.
Of its 221 completed or terminated interventional studies of FDA-regulated products, 168 (76%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants in this arm will participate in the Interventions for Stressful Transitions in Later Life (InSTILL), a behavioral health intervention tailored to the needs of short stay nursing facility residents and care partners. InSTILL includes 8 sessions (2x per week for about 4 weeks) delivered in person or remotely.
Behavioral: Interventions for Stressful Transitions in Later Life (InSTILL)
The Interventions for Stressful Transitions in Later Life (InSTILL) intervention is for skilled nursing facility residents experiencing elevated levels of psychological distress. The intervention is designed to improve life management skills and emotion regulation skill with the goal of reducing depression symptoms.
Mean Total Score Treatment Credibility
2-item self-report measure of participant's belief regarding how helpful the intervention will be for them. Higher scores (min = 0, max = 4) scores indicate greater credibility.
Time frame: After session 1 of intervention (one week after baseline)
Mean Total Score Client Satisfaction Questionnaire
3-item self-report measure assessing patient satisfaction with the program. Higher total scores (min = 3, max = 12) indicate greater satisfaction.
Time frame: Post-intervention (week 6)
Percentage of Eligible Participants Enrolled
Percentage of eligible approached individuals that are enrolled into the study.
Time frame: Post-intervention (week 6)
Percentage of Participants with Missing Data
Percentage of all participants with no measure fully missing at follow-up.
Time frame: 1-month follow-up (week 10)
Attendance Rate
Percentage of participants completing 6/8 sessions of the intervention.
Time frame: Post-intervention (week 6)
Number of Adverse Events
Number of adverse events related to participation in the study.
Time frame: 1-month follow-up (week 10)
Patient Health Questionnaire-9
9-item self-report measure of depression symptoms. Higher scores (min=0, max=27) indicate greater depressive symptoms.
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
Selection, Optimization, and Compensation (SOC) in Everyday Use
4-item self-report measure of the application of selection, optimization, and compensation strategies in daily life. Items are averaged for a composite score, with higher scores indicate greater SOC strategy use (Range = 1-6).
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
PROMIS Short Form v1.0 - Self-Efficacy for Managing Emotions 4a
4-item self-report measure of ability to manage difficult emotions. Higher scores indicate greater use and effectiveness of emotional regulation skills; raw scores will be converted to T-scores (normed, M=50, SD=10).
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
PROMIS Global Mental Health-4
4-item self report of overall emotional wellbeing. Raw scores are converted to T-scores (normed, M=50, SD=10)
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
Euro QoL-5D 5L
6-item self-report measure of subjective health-related quality of life. Higher scores indicate worse health-related quality of life (Range = 5-25). The scale also includes a separately scored single-item global health indicator, asked on a 0-100 scale with higher scores indicate higher subjective health-related quality of life.
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
CoreQ
4-item self-report of nursing facility satisfaction. Higher averaged scores indicate greater facility satisfaction (Range = 1-5).
Time frame: Post-intervention (week 6)
University of Washington Resilience Scale Short Form
4-item self-report of an individual's perceived resilience. Summed scores will be converted to T-scores using a conversion table.
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
Psychotropic medication use
Chart or self reported psychotropic medication use. Patients will self-report changes to medication, including dosage, at post-intervention and follow-up
Time frame: pre-intervention (week 0); post-intervention (week 6); 1 month follow-up (week 10)
Re-hospitalization
Resident re-hospitalization during the study period
Time frame: post-intervention (week 6); 1 month follow-up (week 10)
Plan to share: No
No publications or documents are linked to this record.
Ran from Feb 2025 to primary completion in Dec 2025, 10 months.
Of 3,016 non-industry interventional studies with no phase under Depression, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's 10 months is below that.
Counting every sponsor, half of 3,112 studies reached it within 22 months; a quarter within 10 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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