Drug
Duloxetine clinical trials
Also written Cymbalta, LY248686 and Xeristar.
Keep track of what changes. Save the duloxetine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
272 studies that test it; most in 2007 (22); 1 more planned to start later
| Year | Studies |
|---|---|
| 1996 | 1 |
| 2001 | 6 |
| 2002 | 8 |
| 2003 | 9 |
| 2004 | 13 |
| 2005 | 17 |
| 2006 | 20 |
| 2007 | 22 |
| 2008 | 16 |
| 2009 | 20 |
| 2010 | 12 |
| 2011 | 12 |
| 2012 | 5 |
| 2013 | 6 |
| 2014 | 7 |
| 2015 | 8 |
| 2016 | 10 |
| 2017 | 8 |
| 2018 | 8 |
| 2019 | 4 |
| 2020 | 11 |
| 2021 | 18 |
| 2022 | 7 |
| 2023 | 7 |
| 2024 | 9 |
| 2025 | 3 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 106 · Other 168
Eli Lilly and Company (90) · Assiut University (8) · Rambam Health Care Campus (8) · New York State Psychiatric Institute (5) · Stanford University (4) · Massachusetts General Hospital (4) · University of Cincinnati (4) · Northwestern University (4)
Often tested with
Tested in the same studies.
Pregabalin (19) · Escitalopram (11) · Venlafaxine (7) · Paroxetine (5) · Gabapentin (4) · Fluoxetine (4) · Amitriptyline (4) · Sertraline (3)
Related medicines
As reviewed, each with the page that says it.
- One of Analgesics source
- One of Dopamine Agents source
- One of Serotonin and Noradrenaline Reuptake Inhibitors source
Studies
Open first, then newest update. How each study uses duloxetine is read from its arms, and is right about nine times in ten.
Testing it · 274
- Personalized Analgesia Through Central Nervous System Engagement to Unlock PerformanceRecruitingPhase 4Benedict AlterNCT07759336Written as Duloxetine
- SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.RecruitingPhase 2University of RochesterNCT06614322Written as Duloxetine
- Algorithm-informed Decision-making to Advance Pain TreatmentRecruitingNot applicableUniversity of MichiganNCT07731750Written as Duloxetine
- Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral NeuropathyRecruitingPhase 2Yan Yang, MD, Ph.DNCT04970121Written as Duloxetine
- Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography PancreatitisRecruitingPhase 3Tanta UniversityNCT06860984Written as Duloxetine
- Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)RecruitingPhase 4Sunnybrook Health Sciences CentreNCT06423716Written as Duloxetine
- Duloxetine in Inflammatory Bowel DiseasesRecruitingPhase 2University of PennsylvaniaNCT07431606Written as Duloxetine
- Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)Not yet recruitingPhase 2VA Office of Research and DevelopmentNCT07649291Written as Duloxetine
- Identifying and Treating Depression in the Orthopaedic Trauma PopulationRecruitingPhase 4Wake Forest University Health SciencesNCT05976347Written as Duloxetine 30 MG
- Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee OsteoarthritisRecruitingPhase 4Northwestern UniversityNCT06245109Written as Duloxetine
- Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCTRecruitingPhase 4University of MiamiNCT06807866Written as Duloxetine
- Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility FracturesRecruitingPhase 4Wake Forest University Health SciencesNCT05851898Written as Duloxetine 30 mg
- Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain SyndromeRecruitingNot applicableCairo UniversityNCT07421427Written as Pregabalin + Duloxetine
- Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)RecruitingPhase 1/2First Affiliated Hospital of Chongqing Medical UniversityNCT05814640Written as Duloxetine
- Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic CoughRecruitingPhase 2Mayo ClinicNCT05110144Written as Duloxetine 30 MG
- Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related CoughRecruitingPhase 2Mayo ClinicNCT05120934Written as Duloxetine 30 MG
- Duloxetine for LBPRecruitingPhase 4Montefiore Medical CenterNCT05851976Written as Duloxetine
- Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast CancerNot yet recruitingPhase 3European Organisation for Research and Treatment of Cancer - EORTCNCT06407401Written as Duloxetine 60 MG
- ADC-induced Neurotoxicity Treated With DuloxetineRecruitingPhase 2Fudan UniversityNCT06551051Written as duloxetine
- Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)RecruitingPhase 4University of CincinnatiNCT04245748Written as Duloxetine
See all 274 studies that test duloxetine →
Given in every arm · 19 — duloxetine is usual care beside what is tested
- Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral NeuropathyNot yet recruitingNot applicableBangladesh Medical UniversityNCT07785544Written as Duloxetine
- Impact of Virtual Reality Pelvic Floor Training on Postpartum Stress Urinary IncontinenceNot yet recruitingNot applicableCairo UniversityNCT07455838Written as Medical treatment
- Ketamine for Postherpetic Neuralgia With DepressionNot yet recruitingPhase 4Huazhong University of Science and TechnologyNCT06968624Written as Oral Duloxetine 60mg
- Pain Response Evaluation of a Combined Intervention to Cope EffectivelyCompletedPhase 4Wake Forest University Health SciencesNCT04395001Written as duloxetine
- A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02493868Written as Duloxetine (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02422186Written as Duloxetine (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT03434041Written as Duloxetine (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02417064Written as Duloxetine (Oral Antidepressant)
- A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02497287Written as Duloxetine (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02418585Written as Duloxetine (Oral Antidepressant)
- A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant DepressionWithdrawnPhase 3Janssen-Cilag International NVNCT03852160Written as Duloxetine
- A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive DisorderCompletedPhase 3BiogenNCT04476030Written as Duloxetine
- The Effect of Transcutaneous Posterior Tibial Nerve Stimulation in Patients With FibromyalgiaCompletedNot applicableIlker Fatih SariNCT05937711Written as Duloxetine 30 MG
- The Clinical Effect of Pregabalin on Neuropathic Pain in Central Sensitized Patients After Total Knee ArthroplastyStatus unknownNot applicableThe Catholic University of KoreaNCT05254652Written as Duloxetine 30mg
- Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)CompletedPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT01360866Written as Duloxetine
- Interpersonal Psychotherapy for Treatment Resistant DepressionStatus unknownNot applicableHospital de Clinicas de Porto AlegreNCT01896349Written as Duloxetine
- Antidepressant Medication Plus Donepezil for Treating Late-life DepressionCompletedPhase 4University of PittsburghNCT00177671Written as Duloxetine
- Early Versus Delayed Switch in Medication in Patients With Major Depressive DisorderCompletedPhase 4Eli Lilly and CompanyNCT00810069Written as Duloxetine Hydrochloride
- Chronos: the Use of Chronobiological Treatment in DepressionCompletedNot applicableHillerod Hospital, DenmarkNCT00149110Written as duloxetine
As the comparator · 35 — what is tested is compared with duloxetine
- Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic NeuropathyNot yet recruitingPhase 2Assiut UniversityNCT07882238Written as Duloxetine
- Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral NeuropathyNot yet recruitingPhase 4Wah Medical college , POF hospitalNCT07800468Written as Duloxetine (60 MG)
- Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral NeuropathyRecruitingPhase 3Institut Cancerologie de l'OuestNCT05840562Written as Duloxetine
- Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)RecruitingNot applicableHospital de Clinicas de Porto AlegreNCT07203339Written as Duloxetine 60 mg
- Methadone to Treat Painful Chemotherapy Induced Peripheral NeuropathyRecruitingPhase 2/3University of British ColumbiaNCT05786599Written as duloxetine
- Focal Microvibration and Chronic Lumbosacral Radicular PainNot yet recruitingNot applicableFederico II UniversityNCT06301061Written as Gabapentin; Pregabalin; Duloxetine; Amitriptyline
- Qutenza Versus Duloxetine in Chemotherapy-induced Peripheral Neuropathy (CIPN)RecruitingNot applicableAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT05560516Written as Duloxetine
- Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth SyndromeRecruitingPhase 3Federico II UniversityNCT06025474Written as Duloxetine 60 MG
- Comparison of the Efficacy and Safety of Mirogabalin and Duloxetine in Chemotherapy-induced Peripheral Neuropathy in a Randomized Controlled Trial: a Quality of Life Study in Cancer SurvivorsCompletedNot applicablePusan National University Yangsan HospitalNCT06711978Written as Duloxetine
- Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral NeuropathyWithdrawnPhase 3Eurofarma Laboratorios S.A.NCT06715462Written as Cymbalta®
- Shugan Dingtong Decoction in the Treatment of FibromyalgiaCompletedEarly Phase 1China-Japan Friendship HospitalNCT05508516Written as Duloxetine Hydrochloride
- Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]CompletedPhase 1Craig RushNCT04178993Written as Duloxetine
- Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With DepressionStatus unknownPhase 2CSPC ZhongQi Pharmaceutical Technology Co., Ltd.NCT05018013Written as Duloxetine hydrochloride enteric-coated capsules
- Levomilnacipran in Healthy MalesStatus unknownPhase 4University of OttawaNCT03249311Written as Duloxetine
- Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine SurgeryCompletedPhase 4Serviço de Anestesiologia de JoinvilleNCT02535000Written as Duloxetine
- Comparative Efficacy of Duloxetine vs Escitalopram in Patients With FibromyalgiaCompletedPhase 2/3Shaheed Zulfiqar Ali Bhutto Medical UniversityNCT03487211Written as Duloxetine
- Comparing Lorcaserin Versus Duloxetine for the Treatment of Chemotherapy-Induced Peripheral NeuropathyStatus unknownPhase 2Southeastern Regional Medical CenterNCT03812523Written as Duloxetine 60 mg qd
- Efficacy and Tolerability of Escitalopram and Duloxetine in Outpatients With Major Depressive DisorderCompletedPhase 4H. Lundbeck A/SNCT01148472Written as Duloxetine
- Dose-finding Study With Lu AA24530 in Major Depressive DisorderCompletedPhase 2H. Lundbeck A/SNCT00599911Written as Duloxetine
- Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major DepressionCompletedPhase 2Bristol-Myers SquibbNCT01369095Written as Duloxetine
Showing 20 of 35.
Codes
What other systems call duloxetine · ClinicalTrials.gg INT006534
- MeSH (NLM) D000068736Duloxetine HydrochlorideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) O5TNM5N07UDULOXETINEConfirmed FDA, NLM, Wikidata
- RxNorm 72625Confirmed FDA, Wikidata
- Wikidata Q27116971duloxetine hydrochlorideConfirmed FDA, NLM, Wikidata
- Wikidata Q411932(S)-duloxetineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C65495DuloxetineOne source FDA
- DrugBank DB00476One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000068736 | Duloxetine Hydrochloride | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | O5TNM5N07U | DULOXETINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 72625 | — | Confirmed FDA, Wikidata |
| Wikidata | Q27116971 | duloxetine hydrochloride | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q411932 | (S)-duloxetine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C65495 | Duloxetine | One source FDA |
| DrugBank | DB00476 | — | One source Wikidata |
Also registered as duloxetine hydrochloride (UNII 9044SC542W · RxNorm 476250).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.