VA Office of Research and Development: Depression trials

The registry lists 81 Depression studies with VA Office of Research and Development as lead sponsor. 17 are open to participants now and 51 have results posted.

Phase 1 3Phase 2 12Phase 3 4Phase 4 1No phase 63(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Psilocybin for Depression in VeteransNot yet recruitingNCT07895134Phase 2
• Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)Not yet recruitingNCT07649291Phase 2
• Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0)Not yet recruitingNCT07645274Not applicable
• Pilot Randomized Trial of BA-GSH in VA PC-MHINot yet recruitingNCT07541482Not applicable
• Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingNCT07226232Phase 3
• Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD SymptomsNot yet recruitingNCT07202325Not applicable
• Adaptation and Examination of a Trauma-informed Intervention for Pregnant VeteransRecruitingNCT06906185Not applicable
• Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionRecruitingNCT06419439Phase 2
• Ketamine for Veterans With Parkinson's DiseaseRecruitingNCT06231563Phase 2
• A Computerized Depression Intervention in VeteransRecruitingNCT06217198Not applicable
• A New Intervention to Improve Function in Veterans With Anxiety and DepressionRecruitingNCT06188923Phase 2
• Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for VeteransRecruitingNCT06162741Not applicable
• Bright Light Therapy for OSARecruitingNCT05917119Not applicable
• Expressive Writing on Minority Stressors Among Sexual Minority VeteransRecruitingNCT05897021Not applicable
• Dosing rTMS for Depression Post-SCIRecruitingNCT05553353Not applicable
• Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient CareRecruitingNCT04877197Not applicable
• Allopregnanolone in Chronic Complex Traumatic Brain InjuryNot yet recruitingNCT04003285Phase 2
• An eHealth Intervention to Increase Depression Treatment Initiation and Adherence Among Veterans Referred for Mental Health ServicesCompletedNCT05990075Not applicableResults posted
• Pilot Testing a Virtual Mindfulness-Based Intervention to Improve Veterans' HealthCompletedNCT05975008Not applicableResults posted
• Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment TherapyCompletedNCT05427201Not applicableResults posted
• Designing a Mobile App to Support Academic Success for Student VeteransCompletedNCT05344092Not applicableResults posted
• Improving Depression ManagementCompletedNCT05050227Not applicableResults posted
• ACTIVE: Activity Therapy to Increase Veteran EngagementCompletedNCT04976621Not applicableResults posted
• Compassion Meditation vs. Health Education for VeteransCompletedNCT04651296Phase 2Results posted
• Multiphase Optimization Trial of Incentives for Veterans to Encourage WalkingCompletedNCT04518943Not applicableResults posted
• Effectiveness and Implementation of eScreening in Post 9/11 Transition ProgramsCompletedNCT04506164Not applicableResults posted
• Neurofeedback Impact on Veterans With mTBICompletedNCT04195685Not applicableResults posted
• Predicting SSRI Efficacy in Veterans With PTSDTerminatedNCT04183205Phase 4Results posted
• One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of ChangeCompletedNCT04143243Not applicableResults posted
• Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Rates of DepressionCompletedNCT04002063Not applicableResults posted
• Pilot Study of Annie Text Messaging for Depression Treatment AdherenceCompletedNCT03930849Not applicableResults posted
• Improving Outcomes for Older Veterans With Chronic Back Pain and DepressionCompletedNCT03896035Not applicableResults posted
• Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration WorkshopCompletedNCT03868930Not applicableResults posted
• Aerobic Exercise in Parkinson's DiseaseCompletedNCT03808675Not applicableResults posted
• Neurosteroids for Treatment of PTSD in VeteransCompletedNCT03799562Phase 2Results posted
• A Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in VeteransTerminatedNCT03489122Not applicableResults posted
• PRIME Care (PRecision Medicine In MEntal Health Care)CompletedNCT03170362Not applicableResults posted
• Spanish Intervention for Caregivers of Veterans With StrokeCompletedNCT03142841Not applicableResults posted
• Collaborative Care for Women VeteransCompletedNCT02950961Not applicableResults posted
• Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)CompletedNCT02697435Not applicableResults posted
• Wellness Programs for Brain-Injured IndividualsCompletedNCT02600637Not applicableResults posted
• Ketamine for Treatment Resistant Late-Life DepressionCompletedNCT02556606Phase 3Results posted
• A Computer-Assisted CBT Tool to Enhance Fidelity in CBOCsCompletedNCT02488551Not applicableResults posted
• Telehealth Cognitive Behavioral Therapy for Depression in Parkinson's Disease (PD)CompletedNCT02475954Not applicableResults posted
• Effectiveness and Implementation of Brief Cognitive Behavioral Therapy in CBOCsCompletedNCT02466126Not applicableResults posted
• Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderCompletedNCT02461927Phase 1/2Results posted
• Efficacy of Repeated Ketamine Infusions for Treatment-resistant DepressionCompletedNCT02360280Phase 2Results posted
• Improving Mood in Veterans in Primary CareCompletedNCT02276807Not applicableResults posted
• Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)CompletedNCT02248675Not applicableResults posted
• Reducing the Burden of Depression Related DisabilityCompletedNCT02111811Not applicableResults posted
• Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBICompletedNCT02057081Not applicableResults posted
• Veteran Peer-Assisted Computerized Cognitive Behavioral Therapy for DepressionCompletedNCT02057042Not applicableResults posted
• Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety DisordersCompletedNCT01947647Not applicableResults posted
• Enhancing Delivery of Problem Solving Therapy Using SmartPhone TechnologyCompletedNCT01891734Phase 1/2Results posted
• Comprehensive vs. Assisted Management of Mood and Pain SymptomsCompletedNCT01757301Not applicableResults posted
• Behavioral Activation Therapy for Rural Veterans With Diabetes and DepressionCompletedNCT01572389Not applicableResults posted
• VA Augmentation and Switching Treatments for Improving Depression OutcomesCompletedNCT01421342Phase 3Results posted
• The Effectiveness of rTMS in Depressed VA PatientsCompletedNCT01191333Not applicableResults posted
• Adjusting to Chronic Conditions Using Education, Support, and SkillsCompletedNCT01149772Not applicableResults posted
• Hepatitis C Translating Initiatives for Depression Into Effective SolutionsCompletedNCT01143896Not applicableResults posted
• Project SERVE: Post Deployment FunctioningCompletedNCT01123642Results posted
• Intervention for Veterans With Depression, Substance Disorder, and TraumaCompletedNCT00958217Not applicableResults posted
• Chronic Kidney Disease Antidepressant Sertraline TrialCompletedNCT00946998Phase 3Results posted
• Behavioral Activation for PTSD/Depression Treatment in OIF/OEF VeteransCompletedNCT00805532Not applicableResults posted
• Depression and Congestive Heart Failure in Outpatients.CompletedNCT00321269Not applicableResults posted
• HIV Translating Initiatives for Depression Into Effective SolutionsCompletedNCT00304915Not applicableResults posted
• Implementing Evidence in the Detection and Treatment of Post Stroke DepressionCompletedNCT00296140Not applicableResults posted
• Improving Chronic Pain Treatment in Primary CareCompletedNCT00129480Not applicableResults posted
• Suicide Specific Rumination in VeteransCompletedNCT06481033Not applicable
• VOICES Socials for Older Veterans With DepressionCompletedNCT06145334Not applicable
• Implementation of Collaborative Care for Depression in VA HIV ClinicsActive, not recruitingNCT05901272Not applicable
• MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and DepressionCompletedNCT05220202Not applicable
• Enhancing Mental and Physical Health of Women VeteransActive, not recruitingNCT05050266Not applicable
• Assessing an EEG Biomarker of Response to TMS for Major DepressionActive, not recruitingNCT05008198
• The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical ActivityActive, not recruitingNCT04953806Not applicable
• Participatory System Dynamics vs Usual Quality Improvement: Staff Use of Simulation as an Effective, Scalable and Affordable Way to Improve Timely Mental Health Care?CompletedNCT04208217Not applicable
• rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)CompletedNCT04046536Not applicable
• Improving Brain Stimulation Through ImagingCompletedNCT03851380
• rTMS for Emotional Difficulties in VerteransCompletedNCT03749967Phase 1
• Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills TrainingCompletedNCT03467243Not applicable
• Integrated Intervention for Substance Abusers With Depressive DisordersCompletedNCT00018655Phase 2