An interventional study of Standard physical therapy and Hydrotherapy in Central Sensitization, Knee Osteoarthristis and Aquatic, sponsored by Kirsehir Ahi Evran Universitesi. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by Kirsehir Ahi Evran Universitesi · Not applicable, Interventional, and Health services research
The effect of aquatic exercise on central sensitization in patients with knee osteoarthritis are not fully known in the studies conducted to date. The aim of this study is to examine the effect of aquatic exercise on central sensitization and functional parameters in patients with knee osteoarthritis.
8,240 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's planned enrollment of 60 is below the median of 84 across 6,869 interventional studies indexed under Depression.
Browse Depression studies →Kirsehir Ahi Evran Universitesi is the lead sponsor of 136 studies on the registry; 56 are open to participants now.
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Exclusion Criteria:
Participants receive standard physical therapy sessions for knee osteoarthritis.
Other: Standard physical therapy
• Participants receive standard physical therapy sessions combined with hydrotherapy (pool therapy) sessions for knee osteoarthritis.
Other: Standard physical therapy · Other: Hydrotherapy
Standard physical conventional therapy exercises for knee osteoarthritis.
Hydrotherapy (pool therapy) sessions tailored to standard physiotherapy for knee osteoarthritis.
Central Sensitization
The Central Sensitization Inventory is a valid tool for assessing psychological and sensory factors associated with central pain sensitivity in patients with knee osteoarthritis. The Central Sensitization Inventory demonstrates moderate reliability in patients who have developed central sensitization due to knee osteoarthritis. Part A consists of 25 items that assess an individual's symptoms of central sensitization; it is scored using a 4-point Likert scale. Part B assesses whether the patient has received a diagnosis of another condition within the family of central sensitization syndromes from a physician. A high score indicates severe central sensitization.
Time frame: 8 weeks
Visual Analog Scale
Participants' pain intensity will be assessed. Pain intensity is indicated on a 10 cm straight line with anchor points representing "no pain" and "worst pain imaginable." The distance between the starting point and the point marked by the patient is measured in centimeters. An increase in this distance signifies an increase in pain intensity.
Time frame: 8 weeks
Knee Injury and Osteoarthritis Outcome Score
Knee-related quality of life scales for patients with knee osteoarthritis are tools used to assess pain, function, and activities of daily living. They comprise 42 items across five distinct subscales.
Time frame: 8 weeks
Algometer
Central sensitization is assessed by measuring the Pressure Pain Threshold (PPT). Pressure will be applied to the quadriceps muscle using an algometer until the patient perceives pain. The procedure will be performed three times at 20-second intervals, and the average value will be calculated. Subsequently, the patient will immerse their foot and ankle in cold water (1-4°C) for 60-120 seconds. Following this, the PPT will be measured again at the same point on the quadriceps muscle using the algometer, and the total score will be calculated.
Time frame: 8 weeks
SF-36 Quality of Life Scale
It measures an individual's quality of life. The questionnaire consists of 36 items and 8 sub-parameters (physical functioning, bodily pain, limitations due to physical problems, emotional well-being, social functioning, energy/fatigue, and general health perception).
Time frame: 8 weeks
Biodex Balance Scale
Patients' static balance will be measured using the Biodex Balance System®. Patients will be asked to maintain a balanced standing position on the static platform. The anteroposterior index, mediolateral index, and overall index will be evaluated with eyes open and eyes closed. Each position will be tested three times, and the average value will be recorded. For dynamic balance, level two of the 8-level resistance scale (1 = least stable, 8 = most stable) will be used.
Time frame: 8 weeks
Beck Depression Inventory
It is widely used to assess the severity of depression in patients. It is a questionnaire consisting of 21 items. A high total score indicates a high level of depression severity.
Time frame: 8 weeks
Mini-Mental State Examination
The Mini-Mental test, which measures cognitive functions quickly and in a standardized manner, will be administered in the clinical setting; memory, attention, language, and visuospatial skills are assessed. The total score for the 11 items across these five domains ranges from 0 to 30.
Time frame: 8 weeks
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2026 (actual). Primary completion is estimated for Dec 2026, 6 months after the start.
Of 3,016 non-industry interventional studies with no phase under Depression, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's planned 6 months is below that.
Counting every sponsor, half of 3,112 studies reached it within 22 months; a quarter within 10 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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