Drug
Buprenorphine clinical trials
Also written Butrans™, Subutex, RBP-6000 and EN3409.
- studies test it
- 305
- open now
- 27
- in phase 3
- 89
- first study started
- 1990
Keep track of what changes. Save the Buprenorphine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Combined with it in one product
- Suboxone
- 33
Studies by the year they started
292 studies that test it; most in 2012 (18)
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1991 | 3 |
| 1992 | 10 |
| 1993 | 3 |
| 1994 | 5 |
| 1995 | 4 |
| 1996 | 10 |
| 1997 | 6 |
| 1999 | 5 |
| 2000 | 5 |
| 2001 | 4 |
| 2002 | 3 |
| 2003 | 7 |
| 2004 | 11 |
| 2005 | 6 |
| 2006 | 11 |
| 2007 | 14 |
| 2008 | 13 |
| 2009 | 10 |
| 2010 | 13 |
| 2011 | 12 |
| 2012 | 18 |
| 2013 | 14 |
| 2014 | 9 |
| 2015 | 9 |
| 2016 | 7 |
| 2017 | 6 |
| 2018 | 10 |
| 2019 | 9 |
| 2020 | 8 |
| 2021 | 6 |
| 2022 | 6 |
| 2023 | 9 |
| 2024 | 8 |
| 2025 | 4 |
| 2026 | 13 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 7
- Phase 1
- 52
- Phase 2
- 89
- Phase 3
- 89
- Phase 4
- 69
- No phase
- 20
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 92 · Other 213
National Institute on Drug Abuse (NIDA) (44) · Purdue Pharma LP (27) · Indivior Inc. (17) · Yale University (14) · University of California, Los Angeles (11) · New York State Psychiatric Institute (10) · BioDelivery Sciences International (9) · Johns Hopkins University (7)
Often tested with
Tested in the same studies.
Naloxone (55) · Buprenorphine, Naloxone Drug Combination (16) · Methadone (8) · Naltrexone (6) · Vivitrol (5) · Oxycodone (4) · Morphine (4) · Fentanyl (4)
Studies
Open first, then newest update. How each study uses Buprenorphine is read from its arms, and is right about nine times in ten.
Testing it · 305
- BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)RecruitingPhase 4Icahn School of Medicine at Mount SinaiNCT07786012Written as buprenorphine
- Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy ClinicRecruitingPhase 4Yale UniversityNCT07176351Written as Buprenorphine
- A Bundled Intervention to End Opioid OverdosesRecruitingPhase 4University of Alabama at BirminghamNCT07485335Written as Buprenorphine (Experimental)
- Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic SurgeryRecruitingPhase 4Medical University of SilesiaNCT07434427Written as Group B (Buprenorphine)
- Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency DepartmentsRecruitingPhase 2/3University of British ColumbiaNCT04893525Written as Buprenorphine/naloxone
- A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use DisorderRecruitingPhase 4VA Office of Research and DevelopmentNCT04375033Written as Sublingual buprenorphine with naloxone
- Buprenorphine for the Management of Pain in Children With Sickle Cell DiseaseNot yet recruitingPhase 1Natasha ArcherNCT07799571Written as Buprenorphine Buccal Film [Belbuca]
- Examining Analgesic Synergy and Efficacy in Trauma CareNot yet recruitingPhase 4Wake Forest University Health SciencesNCT07435077Written as Buprenorphine
- NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral SettingsNot yet recruitingPhase 4Duke UniversityNCT06854029Written as Buprenorphine injection
- High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)RecruitingPhase 3Rutgers, The State University of New JerseyNCT05589181Written as High Dose Buprenorphine
- Analgesia With Transdermal Buprenorphine Patch in Adults Undergoing Video-Assisted Thoracoscopic SurgeryRecruitingNot applicableClínica DávilaNCT07733128Written as Buprenorphine (BUP)
- Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl UseRecruitingPhase 2University of PennsylvaniaNCT06379984Written as Buprenorphine
- Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency DepartmentRecruitingPhase 1/2The Cooper Health SystemNCT07430345Written as Buprenorphine 0.15 MG
- A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid UseRecruitingEarly Phase 1Rachel R. LubaNCT06726200Written as Buprenorphine + naloxone (Suboxone)
- Standard Versus High Dose ED-Initiated Buprenorphine InductionRecruitingPhase 3Yale UniversityNCT06494904Written as Buprenorphine
- Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use DisorderRecruitingPhase 2/3New York State Psychiatric InstituteNCT05011266Written as Buprenorphine/naloxone
- Injectable Buprenorphine in Prison: A Preference TrialRecruitingPhase 4LifespanNCT06880718Written as Brixadi (Injectable Buprenorphine)
- Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility TrialRecruitingPhase 4Pouya AzarNCT07439549Written as Buprenorphine hydrochloride and naloxone hydrochloride dihydrate sublingual tablet (2 mg/0.5 mg and 8 mg/2 mg)
- Low-dose Buprenorphine as a Modulator of Social Motivation in SchizophreniaRecruitingPhase 2University of California, Los AngelesNCT05778591Written as Buprenorphine 0.15 MG [Belbuca]
- Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture SurgeryRecruitingPhase 4Jenna-Leigh WilsonNCT06949826Written as Buprenorphine Transdermal System
See all 305 studies that test Buprenorphine →
Given in every arm · 28 — Buprenorphine is usual care beside what is tested
- A Study of Brenipatide in Participants With Opioid Use DisorderRecruitingPhase 2Eli Lilly and CompanyNCT07420283Written as Buprenorphine
- Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use DisorderRecruitingPhase 2University of British ColumbiaNCT04234191Written as Buprenorphine/naloxone
- Buprenorphine Group Medical Visits in Primary CareCompletedPhase 3Montefiore Medical CenterNCT02526212Written as Buprenorphine
- INDV-6001 Multiple-Dose Pharmacokinetic StudyCompletedPhase 2Indivior Inc.NCT06576843Written as Suboxone
- Buprenorphine Extended-Release Subcutaneous Injection (RBP-6000) in High-risk UsersCompletedPhase 4Indivior Inc.NCT04995029Written as Extended-release Buprenorphine
- Onsite Buprenorphine Treatment at Syringe Exchange ProgramsCompletedPhase 2Montefiore Medical CenterNCT03150173Written as Buprenorphine
- SUBLOCADE Rapid Initiation StudyCompletedPhase 4Indivior Inc.NCT03993392Written as TM buprenorphine
- HOPE Consortium Trial to Reduce Pain and Opioid Use in HemodialysisCompletedPhase 2National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT04571619Written as Buprenorphine
- A Study to Assess the Effect of a Single Dose of ASP8062 on the Multiple Dose Safety, Tolerability and Pharmacokinetics of Buprenorphine/Naloxone in Participants With Opioid Use DisorderCompletedPhase 1Astellas Pharma Global Development, Inc.NCT04447287Written as buprenorphine/naloxone
- A Study to Assess the Safety and Efficacy of ASP8062 as an Add-on Therapy to Buprenorphine/Naloxone in Participants With Opioid Use DisorderWithdrawnPhase 2Astellas Pharma Global Development, Inc.NCT05062577Written as buprenorphine/naloxone
- Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use DisorderCompletedPhase 1Indivior Inc.NCT04976855Written as SUBOXONE® sublingual film
- Optimal Treatment of Veterans With PTSD and Comorbid OUDTerminatedPhase 2VA Office of Research and DevelopmentNCT03605342Written as Buprenorphine
- Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSPCompletedNot applicableDuke UniversityNCT05108935Written as Suboxone
- CBT4CBT for Office Based BuprenorphineCompletedPhase 1/2CBT4CBT, LLCNCT03580902Written as Buprenorphine/naloxone
- Medication Maintenance Therapy in Community Pharmacy SettingsStatus unknownPhase 2/3LifespanNCT04139213Written as buprenorphine/naloxone oral product
- Improving Treatment Outcomes for Prescription Opioid DependenceCompletedPhase 2/3University of ArkansasNCT02543944Written as Buprenorphine
- Efficacy of Computer Delivered Community Reinforcement Approach (CRA) (Bup II)CompletedNot applicableVirginia Polytechnic Institute and State UniversityNCT00929253Written as Suboxone
- Clinical Trial of Integrated Treatment for Pain and Opioid DependenceCompletedPhase 1/2Yale UniversityNCT00634803Written as Buprenorphine
- Improving Office Based Treatment of Opioid Use Disorder With TechnologyStatus unknownNot applicableMedicaSafe, Inc.NCT03586466Written as Buprenorphine/naloxone
- Study of a Novel Subcutaneous Depot Formulation of BuprenorphineCompletedPhase 1Indivior Inc.NCT03715634Written as SL Buprenorphine
Showing 20 of 28.
As the comparator · 13 — what is tested is compared with Buprenorphine
- Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.RecruitingPhase 4Yale UniversityNCT06323824Written as Buprenorphine (BUP)
- Assessing Optimal XRB Initiation Points in JailRecruitingPhase 4NYU Langone HealthNCT06051890Written as Sublingual Buprenorphine (SLB)
- Extended-Release Buprenorphine vs. Sublingual Buprenorphine for the Treatment of Opioid Use DisorderCompletedPhase 2Frances R LevinNCT04352166Written as sublingual buprenorphine (BSL)
- Monthly Versus Daily Buprenorphine Formulations for Treatment of Opiate Use DisorderStatus unknownPhase 4Royal Victoria Hospital, CanadaNCT05594121Written as Immediate Release Sublingual Buprenorphine
- Extended Release Naltrexone for Opioid-Dependent YouthCompletedPhase 4Friends Research Institute, Inc.NCT01843023Written as Buprenorphine
- Comparison of Three Opioid Detoxification Treatment RegimensWithdrawnPhase 3University of Alabama at BirminghamNCT03678792Written as Buprenorphine/naloxone
- Medications Development for Drug Abuse DisordersCompletedPhase 1/2Johns Hopkins UniversityNCT01188421Written as Buprenorphine/naloxone
- A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED)CompletedPhase 4Merck Sharp & Dohme LLCNCT00604188Written as Suboxone (SCH 000484)
- Efficacy of BNX Sublingual Tablets Versus BNX Sublingual Film for Treatment of Opioid-Dependent AdultsCompletedPhase 3Orexo ABNCT01908842Written as Buprenorphine
- Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid DependenceCompletedPhase 3Orexo ABNCT01848054Written as Buprenorphine
- The Safety of Using Buprenorphine With Naloxone in a Buccal Film to Initiate Treatment of Opioid Dependent SubjectsWithdrawnPhase 3BioDelivery Sciences InternationalNCT02516436Written as Buprenorphine
- A Study of the Abuse Liability Potential of ALKS 5461 in Healthy, Non-Dependent, Recreational Opioid UsersCompletedPhase 1Alkermes, Inc.NCT02413281Written as Buprenorphine
- Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent AdolescentsWithdrawnPhase 4State University of New York at BuffaloNCT01015066Written as Buprenorphine/naloxone
Codes
What other systems call Buprenorphine · ClinicalTrials.gg INT007099
- MeSH (NLM) D002047BuprenorphineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 40D3SCR4GZBUPRENORPHINEConfirmed FDA, NLM, Wikidata
- RxNorm 1819Confirmed FDA, Wikidata
- Wikidata Q407721buprenorphineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61656BuprenorphineOne source FDA
- DrugBank DB00921One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002047 | Buprenorphine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 40D3SCR4GZ | BUPRENORPHINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1819 | — | Confirmed FDA, Wikidata |
| Wikidata | Q407721 | buprenorphine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61656 | Buprenorphine | One source FDA |
| DrugBank | DB00921 | — | One source Wikidata |
Also registered as buprenorphine hydrochloride (UNII 56W8MW3EN1 · RxNorm 203841).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.