Drug
Naloxone clinical trials
Also written Narcan.
- studies test it
- 147
- open now
- 9
- in phase 3
- 23
- first study started
- 1995
Keep track of what changes. Save the Naloxone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
142 studies that test it; most in 2013 (11); 2 more planned to start later
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1996 | 4 |
| 1997 | 1 |
| 1999 | 2 |
| 2000 | 3 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 3 |
| 2004 | 3 |
| 2006 | 2 |
| 2007 | 6 |
| 2008 | 5 |
| 2009 | 8 |
| 2010 | 4 |
| 2011 | 8 |
| 2012 | 8 |
| 2013 | 11 |
| 2014 | 8 |
| 2015 | 6 |
| 2016 | 5 |
| 2017 | 7 |
| 2018 | 8 |
| 2019 | 5 |
| 2020 | 4 |
| 2021 | 8 |
| 2022 | 6 |
| 2023 | 4 |
| 2024 | 5 |
| 2025 | 1 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 8
- Phase 1
- 32
- Phase 2
- 35
- Phase 3
- 23
- Phase 4
- 38
- No phase
- 22
What it is tested for
Each study’s main condition, where its own words name it.
- Pain
- 3
Who runs them
Industry 25 · Other 122
National Institute on Drug Abuse (NIDA) (14) · University of California, San Francisco (5) · Massachusetts General Hospital (4) · New York State Psychiatric Institute (4) · Mundipharma Korea Ltd (4) · University of California, Los Angeles (4) · University of Maryland, Baltimore (3) · University of Pennsylvania (3)
Often tested with
Tested in the same studies.
Buprenorphine (55) · Oxycodone (11) · Methadone (4) · Methylnaltrexone (3) · Naltrexone (3) · Morphine (2) · Vivitrol (2) · Acetaminophen (2)
Studies
Open first, then newest update. How each study uses Naloxone is read from its arms, and is right about nine times in ten.
Testing it · 147
- Sedation and Guided Education for Depression StudyNot yet recruitingNot applicableStanford UniversityNCT06705270Written as IV naloxone
- Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency DepartmentsRecruitingPhase 2/3University of British ColumbiaNCT04893525Written as Buprenorphine/naloxone
- Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingPhase 2University of California, San FranciscoNCT06251609Written as Naloxone 2 MG
- A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use DisorderRecruitingPhase 4VA Office of Research and DevelopmentNCT04375033Written as Sublingual buprenorphine with naloxone
- Naloxone for In-Hospital Cardiac ArrestNot yet recruitingPhase 2/3Region SkaneNCT07806565Written as naloxone
- Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use DisorderRecruitingPhase 2/3New York State Psychiatric InstituteNCT05011266Written as Buprenorphine/naloxone
- Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility TrialRecruitingPhase 4Pouya AzarNCT07439549Written as Naloxone Hydrochloride 0.4 MG/ML
- RM1 Project 1 - tAN NaloxoneRecruitingEarly Phase 1Medical University of South CarolinaNCT05490134Written as Naloxone
- Endogenous Opioid Response to InjectionsRecruitingPhase 4Middle Tennessee Research InstituteNCT06666621Written as Naloxone infusion
- Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid MechanismsCompletedPhase 4Vanderbilt University Medical CenterNCT05142267Written as Naloxone
- Reversal of Opioid-induced Respiratory Depression With Opioid AntagonistsTerminatedPhase 1Leiden University Medical CenterNCT05338632Written as Narcan 40 MG/ML Nasal Spray
- Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use FentanylActive, not recruitingPhase 3University of Maryland, BaltimoreNCT06089707Written as Naloxone Nasal Spray
- Opioid Antagonism in Hypogonadotropic HypogonadismCompletedPhase 1Stephanie B. Seminara, MDNCT04975334Written as Naloxone
- Mechanisms of Hypoglycemia Associated Autonomic FailureTerminatedPhase 2Albert Einstein College of MedicineNCT00678145Written as naloxone
- Buprenorphine Treatment: A Safe Alternative for Opioid Dependent Pain PatientsTerminatedPhase 4Theresa Jacob, PhD, MPHNCT01841931Written as Buprenorphine/Naloxone
- Pharmacokinetics of Intravenous and Intranasal Formulations of Naloxone in Healthy Volunteers.CompletedPhase 1Parc de Salut MarNCT06306391Written as Intravenous naloxone
- Neural Correlates of Hypoalgesia Driven by ObservationCompletedPhase 2University of Maryland, BaltimoreNCT03897998Written as Naloxone
- Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1TerminatedPhase 2University of PennsylvaniaNCT04480554Written as Buprenorphine/naloxone
- Neural Mechanisms of Immersive Virtual Reality in Chronic PainActive, not recruitingPhase 1/2University of Maryland, BaltimoreNCT04851301Written as Naloxone
- Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare BiobankCompletedPhase 1Stephanie B. Seminara, MDNCT04975347Written as Naloxone
See all 147 studies that test Naloxone →
Given in every arm · 17 — Naloxone is usual care beside what is tested
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone BlockadeRecruitingPhase 2Clear Scientific, Inc.NCT07459166Written as Naloxone Hydrochloride
- Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use DisorderRecruitingPhase 2University of British ColumbiaNCT04234191Written as Buprenorphine/naloxone
- Multi-System Analysis of Opioid Receptor BindingActive, not recruitingPhase 1University of PennsylvaniaNCT05528848Written as Naloxone
- Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back PainActive, not recruitingEarly Phase 1Rush University Medical CenterNCT04744883Written as Naloxone
- A Study to Assess the Effect of a Single Dose of ASP8062 on the Multiple Dose Safety, Tolerability and Pharmacokinetics of Buprenorphine/Naloxone in Participants With Opioid Use DisorderCompletedPhase 1Astellas Pharma Global Development, Inc.NCT04447287Written as buprenorphine/naloxone
- A Study to Assess the Safety and Efficacy of ASP8062 as an Add-on Therapy to Buprenorphine/Naloxone in Participants With Opioid Use DisorderWithdrawnPhase 2Astellas Pharma Global Development, Inc.NCT05062577Written as buprenorphine/naloxone
- Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use DisorderCompletedPhase 1Indivior Inc.NCT04976855Written as SUBOXONE® sublingual film
- Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst StimulationCompletedNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT05360030Written as Naloxone
- CBT4CBT for Office Based BuprenorphineCompletedPhase 1/2CBT4CBT, LLCNCT03580902Written as Buprenorphine/naloxone
- Medication Maintenance Therapy in Community Pharmacy SettingsStatus unknownPhase 2/3LifespanNCT04139213Written as buprenorphine/naloxone oral product
- Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid FunctionCompletedNot applicableVanderbilt University Medical CenterNCT02469077Written as naloxone
- A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid OverdosesCompletedNot applicableUniversity of CincinnatiNCT02922959Written as naloxone nasal spray kit
- Improving Office Based Treatment of Opioid Use Disorder With TechnologyStatus unknownNot applicableMedicaSafe, Inc.NCT03586466Written as Buprenorphine/naloxone
- The Role of Opioidergic Systems in Breathing Based AnalgesiaCompletedEarly Phase 1University of California, San DiegoNCT03419858Written as Naloxone
- Multiple Dose Study of Blockade of Opioid Effects by Injections of Buprenorphine in Participants With Opioid DisorderCompletedPhase 2Indivior Inc.NCT02044094Written as buprenorphine and naloxone
- Comparison of Naloxone PharmacokineticsCompletedPhase 1National Institute on Drug Abuse (NIDA)NCT03386591Written as Naloxone
- Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?Status unknownPhase 2Hanyang University Seoul HospitalNCT02307305Written as celecoxib, naproxen/esomeprazole, acetaminophen/tramadol, oxycodone/naloxone
As the comparator · 13 — what is tested is compared with Naloxone
- Pharmacodynamic Evaluation of Intranasal NalmefeneCompletedPhase 1Opiant Pharmaceuticals IncNCT04828005Written as Naloxone hydrochloride
- Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mgCompletedPhase 1Purdue Pharma LPNCT06719986Written as Naloxone HCl intranasal
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid OverdoseWithdrawnPhase 3University of New MexicoNCT06408714Written as Naloxone Injection
- Clinical Outcomes From NalmefeneWithdrawnPhase 4Purdue Pharma LPNCT05808881Written as Naloxone Hydrochloride Injection
- Pharmacokinetic Evaluation of a New Naloxone Nasal Swab, Naloxone Nasal Spray, and Intramuscular Naloxone Injection in Healthy VolunteersCompletedPhase 1Pocket Naloxone CorpNCT05363501Written as Naloxone Nasal Spray
- A Pilot Study of the Bioavailability of Nasal NaloxoneCompletedPhase 2Norwegian University of Science and TechnologyNCT01939444Written as naloxone intravenous
- Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the HospitalCompletedPhase 3Norwegian University of Science and TechnologyNCT03518021Written as Naloxone, intramuscular
- Comparison of Three Opioid Detoxification Treatment RegimensWithdrawnPhase 3University of Alabama at BirminghamNCT03678792Written as Buprenorphine/naloxone
- Medications Development for Drug Abuse DisordersCompletedPhase 1/2Johns Hopkins UniversityNCT01188421Written as Buprenorphine/naloxone
- Abuse Liability of Suboxone Versus SubutexCompletedPhase 3New York State Psychiatric InstituteNCT00710385Written as Naloxone
- To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer PainCompletedPhase 2/3Mundipharma Research GmbH & Co KGNCT02321397Written as Naloxone
- Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent AdolescentsWithdrawnPhase 4State University of New York at BuffaloNCT01015066Written as Buprenorphine/naloxone
- Opioid Effects on Swallowing and Esophageal Sphincter PressureCompletedPhase 4Region Örebro CountyNCT01191645Written as naloxone
Codes
What other systems call Naloxone · ClinicalTrials.gg INT007866
- MeSH (NLM) D009270NaloxoneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 36B82AMQ7NNALOXONEConfirmed FDA, NLM, Wikidata
- RxNorm 7242Confirmed FDA, Wikidata
- Wikidata Q282902naloxoneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62054NaloxoneOne source FDA
- DrugBank DB01183One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D009270 | Naloxone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 36B82AMQ7N | NALOXONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7242 | — | Confirmed FDA, Wikidata |
| Wikidata | Q282902 | naloxone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62054 | Naloxone | One source FDA |
| DrugBank | DB01183 | — | One source Wikidata |
Also registered as naloxone hydrochloride (UNII F850569PQR · RxNorm 203192).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.