Drug
Methadone clinical trials
Also written Dolophine and Methadose.
Includes 11 studies of D-methadone.
- studies test it
- 164
- open now
- 28
- in phase 3
- 38
- first study started
- 1995
Keep track of what changes. Save the Methadone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Other names
Studies by the year they started
160 studies that test it; most in 2009 (11)
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 1 |
| 2000 | 1 |
| 2003 | 1 |
| 2004 | 4 |
| 2005 | 5 |
| 2006 | 2 |
| 2007 | 5 |
| 2008 | 4 |
| 2009 | 11 |
| 2010 | 9 |
| 2011 | 8 |
| 2012 | 4 |
| 2013 | 7 |
| 2014 | 8 |
| 2015 | 3 |
| 2016 | 10 |
| 2017 | 6 |
| 2018 | 5 |
| 2019 | 6 |
| 2020 | 4 |
| 2021 | 7 |
| 2022 | 6 |
| 2023 | 10 |
| 2024 | 8 |
| 2025 | 10 |
| 2026 | 11 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 5
- Phase 1
- 34
- Phase 2
- 25
- Phase 3
- 38
- Phase 4
- 51
- No phase
- 19
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 26 · Other 138
Endeavor Health (7) · Relmada Therapeutics, Inc. (6) · University of Aarhus (5) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Merck Sharp & Dohme LLC (4) · Duke University (4) · Yale University (4) · University of Pennsylvania (4)
Often tested with
Tested in the same studies.
Morphine (12) · Buprenorphine (8) · Hydromorphone (6) · Ketamine (5) · Fentanyl (5) · Naloxone (4) · Sufentanil (3) · Buprenorphine, Naloxone Drug Combination (3)
Studies
Open first, then newest update. How each study uses Methadone is read from its arms, and is right about nine times in ten.
Testing it · 164
- MethaLoad Dose-Finding StudyRecruitingPhase 1Ashish P Thakrar, MD MSNCT06877858Written as Methadone hydrochloride
- Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck CancersRecruitingPhase 4OHSU Knight Cancer InstituteNCT07857655Written as Methadone
- A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)RecruitingPhase 1Merck Sharp & Dohme LLCNCT07595263Written as Methadone
- Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.RecruitingPhase 4Yale UniversityNCT06323824Written as Methadone
- Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10Not yet recruitingNot applicableClinica Alemana de SantiagoNCT07777029Written as Methadone 0.15 mg/kg
- Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PKRecruitingEarly Phase 1Indiana UniversityNCT05789173Written as Methadone and Tizanidine
- Methadone for Post-operative Spine SurgeryRecruitingPhase 4Brandon KnoppNCT07517679Written as Methadone
- Methadone in the Management of Post-Operative Pain in Total Knee ReplacementRecruitingPhase 4AdventHealthNCT07485803Written as Methadone
- Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)Not yet recruitingPhase 3Alexandre P. JoostenNCT07565870Written as Intravenous Methadone
- Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy SurgeryRecruitingEarly Phase 1University of VirginiaNCT06810336Written as Methadone
- Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational ReconstructionRecruitingPhase 4Indiana UniversityNCT06784999Written as methadone
- Methadone Rapid RestartNot yet recruitingPhase 4Pouya AzarNCT07546396Written as Methadone
- Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate SurgeryRecruitingPhase 4Duke UniversityNCT06962306Written as Methadone hydrochloride
- Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing SurgeryRecruitingPhase 4Mayo ClinicNCT06525740Written as Methadone
- Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.RecruitingPhase 3Indiana UniversityNCT06593665Written as Intravenous Methadone
- Methadone in THA for Post-op Pain and Opioid ReductionRecruitingPhase 3Medical University of South CarolinaNCT07227064Written as Methadone
- Methadone in TKA for Post-op Pain and Opioid ReductionRecruitingPhase 3Medical University of South CarolinaNCT07226076Written as Methadone Hydrochloride
- Divided or Single Exposure (DOSE) StudyRecruitingPhase 2/3University of Maryland, BaltimoreNCT05459402Written as Methadone (100% dose)
- The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.RecruitingPhase 2Johns Hopkins UniversityNCT06536517Written as Methadone
- Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility StudyRecruitingPhase 4The Cleveland ClinicNCT07222072Written as Methadone
See all 164 studies that test Methadone →
Given in every arm · 6 — Methadone is usual care beside what is tested
- Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation TherapyCompletedPhase 2Roswell Park Cancer InstituteNCT03574792Written as Methadone
- Symptom-inhibited Fentanyl InductionCompletedPhase 4Pouya AzarNCT05905367Written as Methadone
- Pharmacotherapy & CM for Opioid and Cocaine DependenceCompletedPhase 1/2Yale UniversityNCT00838981Written as Methadone
- Pharmacogenetics of Disulfiram for CocaineCompletedPhase 2Baylor College of MedicineNCT00149630Written as Methadone
- Diversion to Treatment for Injection Drug Users Arrested for Possession of HeroinCompletedPhase 1Johns Hopkins UniversityNCT01723527Written as Methadone
- Reducing Drug Use and HIV Risk in Drug-dependent Adults Arrested for ProstitutionCompletedPhase 1Johns Hopkins UniversityNCT01560221Written as Methadone
As the comparator · 15 — what is tested is compared with Methadone
- Oral and Intravenous Methadone for Analgesia in Cardiac SurgeryCompletedPhase 4Mayo ClinicNCT06720415Written as Intravenous methadone
- IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis CorrectionCompletedPhase 4Dr. Casey Stondell, MDNCT05730920Written as Methadone
- Extended-release Pharmacotherapy for Opioid Use DisorderCompletedPhase 3King's College LondonNCT05164549Written as Methadone
- Neurocognitive Effects of Opiate Agonist TreatmentCompletedPhase 4Albert Einstein College of MedicineNCT01733693Written as Methadone
- Slow-Release Oral Morphine for the Treatment of Opioid Use DisorderTerminatedPhase 3M. Eugenia SociasNCT03948464Written as Methadone
- Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain PatientsCompletedPhase 4State University of New York at BuffaloNCT01559454Written as Methadone
- Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use DisorderCompletedPhase 3University of British ColumbiaNCT02502175Written as methadone
- Starting Treatment With Agonist Replacement Therapies (START)CompletedPhase 4University of California, Los AngelesNCT00315341Written as Methadone
- The German Project of Heroin Assisted Treatment of Opiate Dependent PatientsCompletedPhase 3Universitätsklinikum Hamburg-EppendorfNCT00268814Written as Methadone
- RCT Comparing Methadone and Buprenorphine in Pregnant WomenCompletedPhase 3Johns Hopkins UniversityNCT00271219Written as Methadone
- NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate AddictionCompletedPhase 3University of British ColumbiaNCT00175357Written as Methadone
- Buprenorphine Maintenance for Opioid-Addicted Persons in Jail and Post-ReleaseCompletedPhase 1/2National Development and Research Institutes, Inc.NCT00367302Written as methadone
- Buprenorphine and Methadone for Opioid Dependent Chronic Pain PatientsCompletedPhase 4State University of New York at BuffaloNCT00879996Written as Methadone
- Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional ServicesCompletedPhase 2University of OsloNCT00204243Written as Methadone
- Opiate Detoxification Using the Combined Hemoperfusion-hemodialysisStatus unknownPhase 3First People's Hospital of FoshanNCT01021566Written as Methadone
Codes
What other systems call Methadone · ClinicalTrials.gg INT007797
- MeSH (NLM) D008691MethadoneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) UC6VBE7V1ZMETHADONEConfirmed FDA, NLM, Wikidata
- RxNorm 6813Confirmed FDA, Wikidata
- Wikidata Q179996(RS)-methadoneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62044MethadoneOne source FDA
- DrugBank DB00333One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008691 | Methadone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | UC6VBE7V1Z | METHADONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6813 | — | Confirmed FDA, Wikidata |
| Wikidata | Q179996 | (RS)-methadone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62044 | Methadone | One source FDA |
| DrugBank | DB00333 | — | One source Wikidata |
Also registered as methadone hydrochloride (UNII 229809935B · RxNorm 218337).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.