Opiate Overdose clinical trials
The registry lists 72 studies for Opiate Overdose across 8 countries. 12 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-11.
Status
- Completed
- 40
- Recruiting
- 8
- Active, not recruiting
- 6
- Status unknown
- 6
- Withdrawn
- 6
- Not yet recruiting
- 4
Phase
- Phase 1
- 10
- Phase 4
- 6
- Phase 2
- 5
- Phase 3
- 2
Where
- United States
- 58
- Canada
- 4
- United Kingdom
- 2
- Sweden
- 2
- Iran, Islamic Republic of
- 1
- Jordan
- 1
Who runs them
University of Colorado, Denver (3) · Brown University (3) · New York State Psychiatric Institute (3) · Johns Hopkins University (2) · University of Alabama at Birmingham (2) · University of Washington (2) · Purdue Pharma LP (2) · University of Cincinnati (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 72 — search for more.
- Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingNCT06251609Phase 21 country
- UnityPhilly Response App for Overdose ReversalRecruitingNCT06466005Not applicable1 country
- A Bundled Intervention to End Opioid OverdosesNot yet recruitingNCT07485335Phase 41 country
- Machine-Learning Prediction and Reducing Overdoses With EHR NudgesRecruitingNCT06806163Not applicable1 country
- Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level DataRecruitingNCT06768814Not applicable1 country
- Evaluation of Clinical Decision Support in Opioid TaperingNot yet recruitingNCT06527079
- A Bundled InterventionRecruitingNCT06593093Phase 1/21 country
- A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid OverdoseRecruitingNCT07079241Not applicable1 country
- Young Houston Emergency Opioid Engagement SystemRecruitingNCT04811014Phase 41 country
- Serious Game to Teach Opioid Overdose ResponseNot yet recruitingNCT06727786Phase 2
- Removing Barriers: Community Partnering for Innovative Solutions to the Opioid CrisisRecruitingNCT05665179Not applicable1 country
- Improving Availability of Intranasal NaloxoneRecruitingNCT05877118Not applicable1 country
- Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy AdultsCompletedNCT05377255Phase 11 country
- Opioid Rapid Response System: Naloxone Training in CommunitiesCompletedNCT06238128Not applicable1 country
- THRIVE: Culturally AdapTed Harm Reduction InterventionCompletedNCT06609278Not applicable1 country
- Measures to Improve Outcomes After an Opioid OverdoseWithdrawnNCT039682371 country
- Pharmacokinetic (PK) Evaluation of Nalmefene FormulationsCompletedNCT07543276Phase 11 country
- Vending Machine Naloxone Distribution for Your Community (VENDY)Active, not recruitingNCT06429436Phase 41 country
- Evaluating an Intervention to Prevent Overdoses in Rural and Urban CountiesActive, not recruitingNCT05463341Not applicable1 country
- Clinical Decision Support to Improve System Naloxone Co-prescribingActive, not recruitingNCT062716681 country
- Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary CareActive, not recruitingNCT06810076Not applicable1 country
- Supporting Treatment Access and Recovery Through Linkage and SupportActive, not recruitingNCT05713695Not applicable1 country
- Preventing Overdose Using Information and Data From the EnvironmentCompletedNCT05096429Not applicable1 country
- Tailoring Overdose Education for Black ChurchesWithdrawnNCT05645016Not applicable1 country
- More Individualized Care: Assessment and Recovery Through EngagementCompletedNCT05122676Not applicable1 country
- Quantitative Xylazine Measurement in EDCompletedNCT069496051 country
- Recovery Initiation and Management After Overdose (RIMO) ExperimentCompletedNCT03895827Not applicable1 country
- Evaluation of a Novel Intervention to Prevent Polysubstance Overdoses Involving Illicit StimulantsCompletedNCT05493475Not applicable1 country
- The Rhode Island Prescription and Illicit Drug StudyCompletedNCT04372238Not applicable1 country
- Community and Familial Impacts of the Opioid CrisisCompletedNCT051168521 country
- Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mgCompletedNCT06719986Phase 11 country
- Repeated-dose Behavioral Intervention to Reduce Opioid OverdoseCompletedNCT03838510Not applicable1 country
- Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUDCompletedNCT06262347Not applicable1 country
- Vaped Marijuana to Attenuate Naloxone-Precipitated WithdrawalTerminatedNCT05114460Phase 21 country
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid OverdoseWithdrawnNCT06408714Phase 31 country
- Peer Intervention to Link Overdose Survivors to Treatment (PILOT)CompletedNCT05123027Not applicable1 country
- Preventing Opioid Overdose Mortality in the United StatesCompletedNCT03924505Not applicable1 country
- Blood Naloxone Levels Following Intradermal Injection in HumansWithdrawnNCT05876572Phase 4
- FAVOR Opioid Recovery Coaching EvaluationCompletedNCT03798470Not applicable1 country
- Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUDActive, not recruitingNCT059441331 country
- Safety, Tolerability, and Pharmacokinetics of CSX-1004CompletedNCT06005402Phase 11 country
- Pharmacokinetic Evaluation of Intranasal Nalmefene Using Three Dosing RegimensCompletedNCT05219669Phase 11 country
- ARM-ED: Advanced Respiratory Monitoring Events in Drug ToxicityCompletedNCT053581321 country
- Patient Reported Outcomes for Opioid Use DisorderCompletedNCT039851631 country
- An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid OverdosesCompletedNCT04212364Not applicable1 country
- Opioids and Police Safety StudyStatus unknownNCT05008523Not applicable1 country
- Primary Care Intervention to Reduce Prescription Opioid OverdosesCompletedNCT02464410Not applicable1 country
- Clinical Outcomes From NalmefeneWithdrawnNCT05808881Phase 4
- European Cohort Study of the Effectiveness of Take Home NaloxoneStatus unknownNCT050722493 countries
- Extended-release Injectable Buprenorphine for Individuals at High Risk of OverdoseStatus unknownNCT048155901 country