Opiate Overdose clinical trials
The registry lists 70 studies for Opiate Overdose across 7 countries. 11 are recruiting or about to start. 52 of them are mainly about Opiate Overdose (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
New York State Psychiatric Institute (3) · University of Colorado, Denver (3) · University of Alabama at Birmingham (3) · Brown University (3) · University of Pittsburgh (2) · Kaiser Permanente (2) · Region Skane (2) · Drexel University (2)
What is being tested here
Drugs under test in Opiate Overdose studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Naloxone | 1 | 0 | 4 |
| Buprenorphine | 1 | 0 | 1 |
| Nalmefene | 0 | 1 | 5 |
| Magnesium Chloride | 0 | 0 | 1 |
| Cannabis sativa subsp. indica TOP | 0 | 0 | 1 |
Drug classes tested here Opioid antagonists 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Supporting Treatment Access and Recovery Through Linkage and Support · University of Massachusetts, Worcester
- Dec 2026Serious Game to Teach Opioid Overdose Response · University of Nevada, Reno
- Mar 2027Evaluation of Clinical Decision Support in Opioid Tapering · University of Colorado, Denver
- Aug 2027A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose · Region Skane
Who these studies take
Of the 8 Opiate Overdose studies recruiting now, 6 (75%) set no upper age limit and 2 (25%) stop at 75 or younger. 1 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (38%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (63%) | 5 (63%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 7 (88%) | 7 (88%) |
| 75 | 6 (75%) | 6 (75%) |
| 85 | 6 (75%) | 6 (75%) |
Across all 70 studies, recruiting or not: 27% stop at 75 or younger and 24% at 65; 14% take children; 0% are for women only and 0% for men only; 39% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Opiate Overdose studies take
Of 28 interventional studies with no phase under Opiate Overdose, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 26 mo14–41 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Results posted1
- A Bundled InterventionOct 28, 2026NCT06593093
Studies
Recruiting first, then most recently updated. Showing 50 of 70. Browse all 70 → or search them.
- A Bundled Intervention to End Opioid OverdosesRecruitingNCT07485335Phase 41 country
- Evaluation of Clinical Decision Support in Opioid TaperingNot yet recruitingNCT06527079
- Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingNCT06251609Phase 21 country
- UnityPhilly Response App for Overdose ReversalRecruitingNCT06466005Not applicable1 country
- Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level DataRecruitingNCT06768814Not applicable1 country
- Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction ChampionsRecruitingNCT06823453Not applicable1 country
- A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid OverdoseRecruitingNCT07079241Not applicable1 country
- Young Houston Emergency Opioid Engagement SystemRecruitingNCT04811014Phase 41 country
- Serious Game to Teach Opioid Overdose ResponseNot yet recruitingNCT06727786Phase 2
- Removing Barriers: Community Partnering for Innovative Solutions to the Opioid CrisisRecruitingNCT05665179Not applicable1 country
- Improving Availability of Intranasal NaloxoneRecruitingNCT05877118Not applicable1 country
- A Bundled InterventionCompletedNCT06593093Phase 41 country
- Supporting Treatment Access and Recovery Through Linkage and SupportActive, not recruitingNCT05713695Not applicable1 country
- Machine-Learning Prediction and Reducing Overdoses With EHR NudgesActive, not recruitingNCT06806163Not applicable1 country
- Clinical Decision Support to Improve System Naloxone Co-prescribingCompletedNCT062716681 country
- Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy AdultsCompletedNCT05377255Phase 11 country
- Opioid Rapid Response System: Naloxone Training in CommunitiesCompletedNCT06238128Not applicable1 country
- The Feasibility of Using the PulsePoint to Facilitate Overdose Education and Naloxone DistributionActive, not recruitingNCT06523985Not applicable1 country
- THRIVE: Culturally AdapTed Harm Reduction InterventionCompletedNCT06609278Not applicable1 country
- Measures to Improve Outcomes After an Opioid OverdoseWithdrawnNCT039682371 country
- Pharmacokinetic (PK) Evaluation of Nalmefene FormulationsCompletedNCT07543276Phase 11 country
- Vending Machine Naloxone Distribution for Your Community (VENDY)Active, not recruitingNCT06429436Phase 41 country
- Evaluating an Intervention to Prevent Overdoses in Rural and Urban CountiesActive, not recruitingNCT05463341Not applicable1 country
- Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary CareActive, not recruitingNCT06810076Not applicable1 country
- Preventing Overdose Using Information and Data From the EnvironmentCompletedNCT05096429Not applicable1 country
- Tailoring Overdose Education for Black ChurchesWithdrawnNCT05645016Not applicable1 country
- More Individualized Care: Assessment and Recovery Through EngagementCompletedNCT05122676Not applicable1 country
- Quantitative Xylazine Measurement in EDCompletedNCT069496051 country
- Recovery Initiation and Management After Overdose (RIMO) ExperimentCompletedNCT03895827Not applicable1 country
- Evaluation of a Novel Intervention to Prevent Polysubstance Overdoses Involving Illicit StimulantsCompletedNCT05493475Not applicable1 country
- The Rhode Island Prescription and Illicit Drug StudyCompletedNCT04372238Not applicable1 country
- Community and Familial Impacts of the Opioid CrisisCompletedNCT051168521 country
- Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mgCompletedNCT06719986Phase 11 country
- Kentucky Access to Recovery EvaluationCompletedNCT058897021 country
- Vaped Marijuana to Attenuate Naloxone-Precipitated WithdrawalTerminatedNCT05114460Phase 21 country
- Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid OverdoseWithdrawnNCT06408714Phase 31 country
- Peer Intervention to Link Overdose Survivors to Treatment (PILOT)CompletedNCT05123027Not applicable1 country
- Preventing Opioid Overdose Mortality in the United StatesCompletedNCT03924505Not applicable1 country
- Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response ProgramCompletedNCT04317053Not applicable1 country
- Blood Naloxone Levels Following Intradermal Injection in HumansWithdrawnNCT05876572Phase 4
- FAVOR Opioid Recovery Coaching EvaluationCompletedNCT03798470Not applicable1 country
- SafetyNet Program for Opioid Use Disorder (OUD)CompletedNCT04253782Not applicable1 country
- Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUDActive, not recruitingNCT059441331 country
- Safety, Tolerability, and Pharmacokinetics of CSX-1004CompletedNCT06005402Phase 11 country
- Pharmacokinetic Evaluation of Intranasal Nalmefene Using Three Dosing RegimensCompletedNCT05219669Phase 11 country
- ARM-ED: Advanced Respiratory Monitoring Events in Drug ToxicityCompletedNCT053581321 country
- Patient Reported Outcomes for Opioid Use DisorderCompletedNCT039851631 country
- Opioids and Police Safety StudyStatus unknownNCT05008523Not applicable1 country
- Increasing Naloxone Access for Persons Who Use OpioidsCompletedNCT04303000Phase 41 country
- Clinical Outcomes From NalmefeneWithdrawnNCT05808881Phase 4