Naloxone: all 147 studies that test it

Page 1 of 2. Open to participants first (9), then studies with results posted, then the rest; newest registration first within each.

• Naloxone for In-Hospital Cardiac ArrestNot yet recruitingNCT07806565Phase 2/3
• Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility TrialRecruitingNCT07439549Phase 4
• Sedation and Guided Education for Depression StudyNot yet recruitingNCT06705270Not applicable
• Endogenous Opioid Response to InjectionsRecruitingNCT06666621Phase 4
• Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingNCT06251609Phase 2
• RM1 Project 1 - tAN NaloxoneRecruitingNCT05490134Early Phase 1
• Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use DisorderRecruitingNCT05011266Phase 2/3
• Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency DepartmentsRecruitingNCT04893525Phase 2/3
• A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use DisorderRecruitingNCT04375033Phase 4
• Pharmacokinetics of Intravenous and Intranasal Formulations of Naloxone in Healthy Volunteers.CompletedNCT06306391Phase 1Results posted
• Vaped Marijuana to Attenuate Naloxone-Precipitated WithdrawalTerminatedNCT05114460Phase 2Results posted
• Opioid Antagonism in Hypogonadotropic HypogonadismCompletedNCT04975334Phase 1Results posted
• Clinical Study to Investigate the Pharmacokinetics of Multiple Repeated Doses of Intranasal NaloxoneCompletedNCT04764630Phase 1Results posted
• Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1TerminatedNCT04480554Phase 2Results posted
• The Effect of Chronic Pain on Delay Discounting in Methadone PatientsTerminatedNCT04473950Phase 1Results posted
• Increasing Naloxone Access for Persons Who Use OpioidsCompletedNCT04303000Phase 4Results posted
• Chronic Low Back Pain and MeditationCompletedNCT04034004Early Phase 1Results posted
• Rapid Initiation of Drug Treatment EngagementCompletedNCT03908437Phase 4Results posted
• Treatment of Chronic Itch in Patients Under Arsenic Exposure With NaloxoneCompletedNCT03751111Phase 1/2Results posted
• Buprenorphine Stabilization and Induction Onto Vivitrol for Heroin-dependent IndividualsTerminatedNCT03711318Phase 3Results posted
• Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)TerminatedNCT03608163Phase 4Results posted
• Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder: CTN 0075CompletedNCT03248947Early Phase 1Results posted
• The Use of Oral Naloxone to Prevent Post Spinal Fusion IleusTerminatedNCT03176316Phase 4Results posted
• Sensory and Opioid Mechanisms of Affective TouchCompletedNCT03096353Early Phase 1Results posted
• Biology and Experience of Eating in Women With ObesityCompletedNCT02805972Phase 2Results posted
• Intra-nasal Naloxone for Treatment of Impaired Awareness of HypoglycemiaTerminatedNCT02700048Phase 1/2Results posted
• Naloxone for Optimizing Hypoxemia Of Lung DonorsCompletedNCT02581111Phase 2/3Results posted
• Buprenorphine/Naloxone Stabilization and Induction Onto Injection NaltrexoneCompletedNCT02294253Phase 2/3Results posted
• Buprenorphine to Improve HIV Care Engagement and OutcomesCompletedNCT01936857Phase 4Results posted
• Determine the Safety and Efficacy of Oxy/Nal Tablets Compared to Oxy PR in Subjects With Cancer PainCompletedNCT01885182Phase 3Results posted
• Buprenorphine vs. Opioid Dose Escalation Among Patients With Chronic PainTerminatedNCT01875848Phase 4Results posted
• Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired SubjectsCompletedNCT01846455Phase 4Results posted
• Dane County Drug Court Study for Addicted OffendersCompletedNCT01843751Phase 3Results posted
• Buprenorphine Treatment: A Safe Alternative for Opioid Dependent Pain PatientsTerminatedNCT01841931Phase 4Results posted
• An Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Spinal DisordersCompletedNCT01811238Phase 4Results posted
• An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY)CompletedNCT01811186Phase 4Results posted
• PROspective Non-interventional Open laBEl Trial for TARGIN in Korean Patients With Cancer PainCompletedNCT01719757Phase 4Results posted
• Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid DependenceCompletedNCT01690546Phase 2Results posted
• Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain PatientsCompletedNCT01559454Phase 4Results posted
• HIV, Buprenorphine, and the Criminal Justice SystemCompletedNCT01550341Not applicableResults posted
• 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical DependenceCompletedNCT01549652Not applicableResults posted
• Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion SurgeryCompletedNCT01531439Not applicableResults posted
• A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123)CompletedNCT01396005Phase 1Results posted
• A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer PatientsCompletedNCT01313780Phase 4Results posted
• Naloxone SR Capsules in Patients With Opioid Induced ConstipationCompletedNCT00984334Phase 2Results posted
• Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT00958919Not applicableResults posted
• Effect of Nalbuphine and Naloxone on Experimentally Induced Skin SensitivityTerminatedNCT00947284Not applicableResults posted
• Buprenorphine and Methadone for Opioid Dependent Chronic Pain PatientsCompletedNCT00879996Phase 4Results posted
• A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to OsteoarthritisCompletedNCT00784810Phase 4Results posted
• Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial PainTerminatedNCT00716807Not applicableResults posted
• Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients on Subutex® (Study P05094)(COMPLETED)CompletedNCT00684073Phase 4Results posted
• Mechanisms of Hypoglycemia Associated Autonomic FailureTerminatedNCT00678145Phase 2Results posted
• Buprenorphine as a Treatment in Opiate Dependent Pain PatientsTerminatedNCT00552578Phase 4Results posted
• Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/AdolescentsCompletedNCT00330343Phase 2Results posted
• Starting Treatment With Agonist Replacement Therapies (START)CompletedNCT00315341Phase 4Results posted
• Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug UsersTerminatedNCT00270257Phase 3Results posted
• Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).TerminatedNCT06406400Phase 1
• Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use FentanylActive, not recruitingNCT06089707Phase 3
• Low-dose Versus a High-dose Sublingual Buprenorphine InductionActive, not recruitingNCT05944952Phase 4
• Novel Induction to Buprenorphine/NaloxoneTerminatedNCT05644587Phase 4
• Reversal of Opioid-induced Respiratory Depression With Opioid AntagonistsTerminatedNCT05338632Phase 1
• A Phase 4 Clinical Study to Investigate the Efficacy and Safety of Naloxone HCI IV in Patients With StrokeCompletedNCT05301712Phase 4
• Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid MechanismsCompletedNCT05142267Phase 4
• Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare BiobankCompletedNCT04975347Phase 1
• Neural Mechanisms of Immersive Virtual Reality in Chronic PainActive, not recruitingNCT04851301Phase 1/2
• Buprenorphine Induction for Fentanyl Dependent Opioid UsersWithdrawnNCT04794790Early Phase 1
• Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant PatientsWithdrawnNCT04771689Phase 4
• A Single-Dose, Bioequivalence Study of FMXIN001 4 mg Microspheres PowderCompletedNCT04713709Phase 1
• Effect of Intrathecal Naloxone in the Incidence of Pruritis After C.SCompletedNCT04518618Not applicable
• Topical Naloxone to Diagnose Ocular PainCompletedNCT04454281Phase 1
• Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder SymptomsWithdrawnNCT04091009Phase 4
• Neural Correlates of Hypoalgesia Driven by ObservationCompletedNCT03897998Phase 2
• Evaluation of Intranasal Naltrexone and NaloxoneCompletedNCT03851731Phase 1
• A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy VolunteersCompletedNCT03827642Phase 1
• A Study to Compare Bioavailability of Naloxone Nasal Spray and Naloxone Hydrochloride (HCl) Intramuscular Injection (IM) in Healthy VolunteersCompletedNCT03827629Phase 1
• Medication Maintenance Therapy in Community Pharmacy SettingsCompletedNCT03766893Early Phase 1
• Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death DeterminationWithdrawnNCT03743805Early Phase 1
• Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal SymptomatologyWithdrawnNCT03740243Phase 4
• Buprenorphine for Probationers and Parolees: Bridging the Gap Into TreatmentSuspendedNCT03616236Phase 3
• Effects of Intranasal Naloxone on Gambling Urges and Craving in Gambling DisorderStatus unknownNCT03430180Phase 2
• Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative OpioiCompletedNCT03372486Not applicable
• Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid UseStatus unknownNCT03266445Phase 4
• Treatment of Gambling Disorder With Fast Acting Opiate Antagonist, Naloxone Nasal SprayCompletedNCT03223896Phase 2
• The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in HealthCompletedNCT03014843Not applicable
• Effect of High-dose Naloxone Following Third Molar ExtractionCompletedNCT02976337Phase 2
• The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.CompletedNCT02885948Phase 4
• The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled StudyCompletedNCT02856087Not applicable
• Buccal Versus Injectable Naloxone: a Phase I Healthy Volunteer StudyStatus unknownNCT02733822Phase 1
• Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn InjuryCompletedNCT02684669Phase 2
• Bioavailability of Nasal Naloxone and Injected Naloxone ComparedCompletedNCT02598856Phase 1
• Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy VolunteersCompletedNCT02572089Phase 1
• Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural AnalgesiaCompletedNCT02516059Phase 4
• Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled AnalgesiaCompletedNCT02416115Not applicable
• Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an OpioidCompletedNCT02405988Not applicable
• Efficacy of Naloxone in Reducing Postictal Central Respiratory Dysfunction in Patients With EpilepsyCompletedNCT02332447Phase 3
• Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital UseCompletedNCT02307721Phase 1/2
• Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Morphine and Naloxone on Motivation (MBBAnalgesic)CompletedNCT02267304Phase 2
• Feasibility Study of Oral Naloxone for Treatment of Methadone-induced ConstipationCompletedNCT02137213Phase 2
• Drug Interaction & Methadone & BuprenorphineCompletedNCT02045693Phase 1
• Treatment of Chronic Pain From OsteoarthritisWithdrawnNCT02032927Phase 4

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