Hypogonadism clinical trials
The registry lists 320 studies for Hypogonadism across more than 10 countries. 39 are recruiting or about to start. 207 of them are mainly about Hypogonadism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 4 narrower conditions too, such as Eunuchism: 439 studies, 75 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Repros Therapeutics Inc. (16) · Massachusetts General Hospital (14) · Gulhane School of Medicine (10) · Clarus Therapeutics, Inc. (7) · Bayer (7) · Baylor College of Medicine (6) · Acerus Pharmaceuticals Corporation (6) · University of Washington (6)
What is being tested here
Drugs under test in Hypogonadism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Androgens 11 open · SERMs 1 open · 5-alpha reductase inhibitors 1 open · Aromatase inhibitors 8
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency · Seattle Institute for Biomedical and Clinical Research
- Nov 2026Peri-Operative Testosterone Administration in Primary Total Hip Arthroplasty · American Hip Institute
- Nov 2026Use of D-Chiro-inositol in Male Functional Hypogonadism Associated With Sexual Dysfunction · Cardarelli Hospital
- Dec 2026Growing up With the Young Endocrine Support System (YESS!) · dr. Laura C. G. de Graaff-Herder
- Dec 2026Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome · Aarhus University Hospital
- Dec 2026Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome · Aarhus University Hospital
- Jan 2027EndoPAT Device for Endothelial Dysfunction in ED · University of California, Irvine
- Jan 2027Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive · Indira IVF Hospital Pvt Ltd
- Jan 2027Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone · Seattle Institute for Biomedical and Clinical Research
- Apr 2027AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary Hypogonadism · Varol TUNALI
Who these studies take
Of the 24 Hypogonadism studies recruiting now, 9 (38%) set no upper age limit and 12 (50%) stop at 75 or younger. 6 (25%) take children under 18. 6 (25%) are for women only and 12 (50%) for men only; 6 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (13%) | 3 (13%) |
| 18 | 12 (50%) | 16 (67%) |
| 30 | 10 (42%) | 17 (71%) |
| 40 | 9 (38%) | 17 (71%) |
| 50 | 7 (29%) | 14 (58%) |
| 65 | 5 (21%) | 13 (54%) |
| 75 | 4 (17%) | 12 (50%) |
| 85 | 4 (17%) | 11 (46%) |
Across all 320 studies, recruiting or not: 57% stop at 75 or younger and 43% at 65; 13% take children; 7% are for women only and 82% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypogonadism studies take
Of 21 phase 4 interventional studies under Hypogonadism, half reached primary completion within 52 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 32 mo18–57 · 13 studies | — | — |
| Phase 4 | 52 mo18–72 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Results posted1
- Aromatase Inhibitors and Weight Loss in Severely Obese Men With HypogonadismOct 19, 2026NCT03490513
Studies
Recruiting first, then most recently updated. Showing 50 of 320. Browse all 320 → or search them.
- 52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With HypogonadismRecruitingNCT06689085Phase 31 country
- Anticipated Stigma, Illness Identity, and Quality of Life in Male HypogonadismRecruitingNCT077525111 country
- Inherited Reproductive DisordersRecruitingNCT015004471 country
- Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer PatientsRecruitingNCT07535905Phase 21 country
- A Dose Ranging Study to Examine TDS-Testosterone 5%Not yet recruitingNCT01894308Phase 21 country
- AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary HypogonadismEnrolling by invitationNCT07761546Not applicable1 country
- Observation of Environment and Reproductive-Endocrine EffectsRecruitingNCT062808071 country
- Adaptions and Resiliency to Multi-Stressor OpeRationsRecruitingNCT06455969Phase 41 country
- Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI TrialNot yet recruitingNCT07742553Phase 2/31 country
- Kisspeptin Administration Subcutaneously to Patients With IHHRecruitingNCT05896293Phase 21 country
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaRecruitingNCT07224438Phase 21 country
- Assessment of Effectiveness of Pelvic Floor Muscle Training With Biofeedback in Male With Hypogonadism and Erectile DysfunctionNot yet recruitingNCT07687173Not applicable1 country
- Testosterone Replacement in Male Cancer Survivors With Fatigue and Low TestosteroneRecruitingNCT04049331Phase 21 country
- Product Transference Study of Testagen™ TDS®-TestosteroneNot yet recruitingNCT02733133Phase 2
- Use of D-Chiro-inositol in Male Functional Hypogonadism Associated With Sexual DysfunctionNot yet recruitingNCT07584772Not applicable
- Effect of Testosterone on Elderly Frail Men With Testosterone DeficiencyNot yet recruitingNCT07512323Phase 21 country
- Male Experiences With Intra Cytoplasmic Sperm Injection (ICSI) and Reduced Sperm QualityRecruitingNCT075464351 country
- Gonadotropin Therapy in Idiopathic Hypogonadal Non-ObstructiveNot yet recruitingNCT07540611Not applicable1 country
- Intratesticular Artery Resistive Index Changes After VaricocelectomyNot yet recruitingNCT07517952Not applicable
- EndoPAT Device for Endothelial Dysfunction in EDRecruitingNCT06720597Not applicable1 country
- Perception of Hormonal Replacement Therapy Among Patients Aged 11 to 17 YearsRecruitingNCT073159321 country
- The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty PopulationRecruitingNCT062472671 country
- Study of the Steroid Hormone Milieu in Obese PatientsRecruitingNCT063416991 country
- Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord InjuryRecruitingNCT04460872Phase 21 country
- Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomyRecruitingNCT04833426Phase 31 country
- Peri-Operative Testosterone Administration in Primary Hip ArthroscopyNot yet recruitingNCT06462482Phase 4
- Peri-Operative Testosterone Administration in Primary Total Hip ArthroplastyNot yet recruitingNCT06608914Phase 4
- Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.RecruitingNCT063574421 country
- Triptorelin for Early Diagnosis of Hypogonadotrophic HypogonadismEnrolling by invitationNCT06691815Not applicable1 country
- Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner SyndromeRecruitingNCT06570460Phase 41 country
- Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner SyndromeRecruitingNCT06544473Phase 41 country
- Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17Not yet recruitingNCT06312761Phase 1/2
- Hormones in Hypogonadotropic HypogonadismRecruitingNCT049276761 country
- Growing up With the Young Endocrine Support System (YESS!)Not yet recruitingNCT04252001Not applicable4 countries
- Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism MenRecruitingNCT04189133Phase 21 country
- Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or PalateRecruitingNCT016011711 country
- Association Between Human Immunodeficiency Virus (HIV) Infection and Male HypogonadismRecruitingNCT047605741 country
- Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)RecruitingNCT03687606Phase 41 country
- A Study to Characterize Epidemiology, Clinical and Genetic Features of Kallmann Syndrome in FinlandEnrolling by invitationNCT00623116Not applicable1 country
- Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU PatientsCompletedNCT03678233Phase 21 country
- Hormonal Regulation of Puberty and FertilityCompletedNCT015115881 country
- Aromatase Inhibitors and Weight Loss in Severely Obese Men With HypogonadismCompletedNCT03490513Phase 41 country
- A Phase 4 Study to Evaluate Adrenal Function in Hypogonadal Men Treated With JATENZO® for 12 MonthsCompletedNCT06385509Phase 41 country
- Study to Compare DITEST to Testosterone Undecanoate in Adult Men With HypogonadismCompletedNCT02966652Phase 11 country
- Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic HypogonadismCompletedNCT04648969Phase 21 country
- The Molecular Basis of Inherited Reproductive DisordersCompletedNCT059718361 country
- Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen DeficiencyActive, not recruitingNCT04301765Phase 21 country
- Evaluation of FPT-20 for the Treatment of Spermatogenesis and Semen DisordersCompletedNCT05399212Not applicable1 country
- 7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement TherapySuspendedNCT061915751 country
- Opioid Antagonism in Hypogonadotropic HypogonadismCompletedNCT04975334Phase 11 country