Pruritus clinical trials

The registry lists 490 studies for Pruritus across more than 10 countries. 93 are recruiting or about to start. 255 of them are mainly about Pruritus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Tinea Pedis too: 561 studies, 100 open.

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Status

Completed: 304
Recruiting: 54
Status unknown: 36
Not yet recruiting: 33
Terminated: 31
Withdrawn: 15

Phase

Phase 2: 127
Phase 3: 94
Phase 4: 41
Phase 1: 37
Early Phase 1: 10

Where

United States: 163
Germany: 58
Canada: 54
China: 48
France: 45
Poland: 42

Who runs them

Aalborg University (25) · Novartis Pharmaceuticals (17) · University Hospital, Brest (15) · Cara Therapeutics, Inc. (15) · GlaxoSmithKline (12) · Incyte Corporation (10) · Pfizer (9) · Vyne Therapeutics Inc. (8)

What is being tested here

Drugs under test in Pruritus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Dupilumab	3	1	7
Roflumilast	3	1	3
Maralixibat	2	1	4
Esketamine	2	0	2
Difelikefalin	1	8	14
Tofacitinib	1	6	8
Linerixibat	1	2	7
Aprepitant	1	0	5
Apremilast	1	2	5
Lidocaine	1	0	4

Drug classes tested here Tyrosine kinase inhibitors (TKIs) 5 open · JAK inhibitors 4 open · Antiemetics 1 open · NK1 receptor antagonists 1 open · Opioid antagonists 1 open

Coming up

14phase 3 studies under way

36studies finish main data collection within a year2 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

May 2027Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa · Phase 3 · Paradigm Therapeutics
Jun 2027Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC) · Phase 3 · Sanofi
Nov 2026Tolerance and Efficacy Open-label Study With RV4421B, in Various Populations With Atopic Dermatitis for 12 Weeks · Pierre Fabre Dermo Cosmetique
Nov 2026Effect of Hand Massage on Chronic Kidney Disease Associated Pruritus in Patients Receiving Hemodialysis · University of Applied Sciences of Western Switzerland
Dec 2026Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study) · Murdoch Childrens Research Institute
Dec 2026Assessing the Efficacy and Safety of Photobiomodulation for the Treatment of Pruritus · Massachusetts General Hospital
Dec 2026Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia. · St. Justine's Hospital
Dec 2026Serum Substance P, Neuropathic Pain, and Central Sensitization Across Treatment Groups in Chronic Plaque Psoriasis · Istanbul Training and Research Hospital
Dec 2026VR-PMR for Post-Burn Symptoms · Johns Hopkins University
Dec 2026Proof of Concept Study to Assess the Pharmacokinetics/Pharmacodynamics of Nemolizumab in Adults With Chronic Pruritus of Unknown Origin (CPUO) · Galderma R&D

Who these studies take

Of the 54 Pruritus studies recruiting now, 22 (41%) set no upper age limit and 24 (44%) stop at 75 or younger. 15 (28%) take children under 18. 5 (9%) are for women only and 0 (0%) for men only; 10 (19%) take healthy volunteers.

Recruiting studies that take each age, of 54
Age	Women	Men
10	7 (13%)	7 (13%)
18	49 (91%)	45 (83%)
30	50 (93%)	45 (83%)
40	50 (93%)	45 (83%)
50	46 (85%)	43 (80%)
65	41 (76%)	40 (74%)
75	33 (61%)	32 (59%)
85	27 (50%)	26 (48%)

Across all 490 studies, recruiting or not: 43% stop at 75 or younger and 32% at 65; 19% take children; 6% are for women only and 2% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Pruritus studies take

Of 52 phase 2 interventional studies under Pruritus, half reached primary completion within 16 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Phase 1	6 mo3–14 · 21 studies	—	—
Phase 2	16 mo10–31 · 52 studies	14 mo10–21 · 37 studies	—
Phase 3	19 mo12–38 · 48 studies	19 mo12–27 · 42 studies	—
Phase 4	22 mo12–33 · 19 studies	—	—
Interventional, no phase	7 mo3–13 · 101 studies	—	7 mo4–14 · 85 studies
Observational	12 mo5–35 · 21 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Show 2 more

Suture Choice for Ostomy CreationOct 28, 2026NCT07900711
A Study to Learn About the Study Medicine Abrocitinib in People With Severe Atopic Dermatitis Who Have Switched From Other TherapiesOct 21, 2026NCT07887867

Studies

Recruiting first, then most recently updated. Showing 50 of 490. Browse all 490 → or search them.