Hyperalgesia clinical trials
The registry lists 166 studies for Hyperalgesia across more than 10 countries. 14 are recruiting or about to start. 77 of them are mainly about Hyperalgesia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Rigshospitalet, Denmark (9) · University Hospital, Clermont-Ferrand (6) · Medical University of Vienna (5) · University Hospital, Basel, Switzerland (5) · Aalborg University (5) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · Seoul National University Hospital (4) · GlaxoSmithKline (3)
What is being tested here
Drugs under test in Hyperalgesia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Esreboxetine | 2 | 2 | 2 |
| Esketamine | 1 | 0 | 3 |
| Nefopam | 1 | 1 | 2 |
| Remifentanil | 0 | 1 | 12 |
| Ketamine | 0 | 2 | 9 |
| Lidocaine | 0 | 0 | 4 |
| Nerve Growth Factor | 0 | 0 | 4 |
| Dextromethorphan | 0 | 0 | 3 |
| Naloxone | 0 | 0 | 3 |
| Acetaminophen | 0 | 0 | 3 |
Drug classes tested here Opioids 18 · NSAIDs 8 · Local anesthetics 7 · COX-2 inhibitors 7 · Opioid antagonists 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Post-operative Analgesic Effect of Oral Nefopam · Hospices Civils de Lyon
- Dec 2026Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery · Tongji Hospital
- Dec 2026Music Therapy During Hypothermia in the NICU · Fundación Santa Fe de Bogota
- Mar 2027STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis · Indiana University
- May 2027Photobiomodulation After Nonsurgical Root Canal Treatment · University of Minnesota
Who these studies take
Of the 8 Hyperalgesia studies recruiting now, 4 (50%) set no upper age limit and 2 (25%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (13%) | 1 (13%) |
| 18 | 8 (100%) | 8 (100%) |
| 30 | 8 (100%) | 8 (100%) |
| 40 | 8 (100%) | 8 (100%) |
| 50 | 8 (100%) | 8 (100%) |
| 65 | 8 (100%) | 8 (100%) |
| 75 | 7 (88%) | 7 (88%) |
| 85 | 5 (63%) | 5 (63%) |
Across all 166 studies, recruiting or not: 57% stop at 75 or younger and 46% at 65; 9% take children; 6% are for women only and 14% for men only; 43% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperalgesia studies take
Of 27 interventional studies with no phase under Hyperalgesia, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 11 mo4–32 · 27 studies | — | 11 mo4–32 · 27 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered2
- Preoperative Capsaicin Patch Treatment to Reduce Pain and Pain Sensitivity After SurgeryNov 6, 2026NCT07922525
- Photobiomodulation After Nonsurgical Root Canal TreatmentOct 21, 2026NCT07886723
Studies
Recruiting first, then most recently updated. Showing 50 of 166. Browse all 166 → or search them.
- Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research DesignRecruitingNCT07398417Phase 31 country
- Open-Label Safety Study of AXS-14 in Subjects With FibromyalgiaEnrolling by invitationNCT07637162Phase 31 country
- Photobiomodulation After Nonsurgical Root Canal TreatmentNot yet recruitingNCT07886723Not applicable1 country
- Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic SurgeryNot yet recruitingNCT076539321 country
- FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full SternotomyNot yet recruitingNCT07637370Not applicable1 country
- Post-operative Analgesic Effect of Oral NefopamRecruitingNCT04576078Phase 21 country
- Music Therapy During Hypothermia in the NICUNot yet recruitingNCT06951269Not applicable1 country
- Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)RecruitingNCT04673981Not applicable1 country
- Survey for Parental Perception of Procedural Analgosedation in Pediatric Age.RecruitingNCT067948791 country
- Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy AdultsRecruitingNCT05819476Not applicable1 country
- Investigation on the Status Quo of Hyperalgesia in Patients After Thoracoscopic Operation and Study on the Effect of Intraoperative InterventionRecruitingNCT06790914Not applicable1 country
- Safety and Efficacy Evaluation of S (+) - Ketamine in ChildrenEnrolling by invitationNCT04834427Phase 41 country
- Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal DeformationsRecruitingNCT04697498Not applicable1 country
- Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in FibromyalgiaRecruitingNCT053571571 country
- Preoperative Capsaicin Patch Treatment to Reduce Pain and Pain Sensitivity After SurgeryCompletedNCT07922525Phase 41 country
- Oliceridine for Remifentanil-Induced Postoperative HyperalgesiaCompletedNCT07913555Phase 41 country
- Impact of Repeatedly-Administered THC-cannabis on Experimental Pain and Abuse Liability in HumansSuspendedNCT04596644Phase 21 country
- Dextromethorphan Effect on Central Sensitization to Pain in Healthy VolunteersCompletedNCT02596360Phase 11 country
- Effect of Ultra-low Dose Naloxone on Remifentanil-Induced HyperalgesiaTerminatedNCT03066739Phase 21 country
- Session-Order Sensitivity of TS and OA in a Capsaicin Crossover ModelCompletedNCT07625475Not applicable1 country
- STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic PancreatitisActive, not recruitingNCT05603702Phase 11 country
- Local Anesthetic Infiltration to Prevent Postoperative Pain After Lumbar SurgeryCompletedNCT00825422Phase 31 country
- Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid TherapyCompletedNCT04902547Not applicable1 country
- Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical TrialCompletedNCT01435798Phase 21 country
- Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical TrialCompletedNCT02218203Phase 21 country
- Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine SurgeryTerminatedNCT06096181Phase 21 country
- Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and MethadoneCompletedNCT01594047Not applicable1 country
- Hyperalgesia and PainCompletedNCT01581450Phase 11 country
- Repeated Cannabis Administration on Experimental Pain and Abuse LiabilityCompletedNCT04576507Phase 21 country
- Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation ModelCompletedNCT07092215Early Phase 11 country
- Internet-delivered Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN)WithdrawnNCT05556447Not applicable
- Preventing Pain After Heart SurgeryCompletedNCT01480765Phase 41 country
- Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass GraftingCompletedNCT03450161Phase 41 country
- Pain Medicine for Wound Care ProceduresCompletedNCT00701909Phase 32 countries
- Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn InjuryCompletedNCT02684669Phase 21 country
- Effect of High-dose Naloxone Following Third Molar ExtractionCompletedNCT02976337Phase 21 country
- Effect of High-dose Naloxone Infusion on Pain and Hyperalgesia in Patients Following Groin-Hernia Repair.CompletedNCT01992146Phase 21 country
- An Observational Study of Distress, Immune Function, and Pain in HIV.CompletedNCT047579871 country
- Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber ActivationCompletedNCT05440266Not applicable1 country
- Childhood Adversity, Inflammatory Reactivity and Persistent PainCompletedNCT061276931 country
- The Effect of Remimazolam on Opioid Induced HyperalgesiaCompletedNCT05866315Not applicable1 country
- Feasibility Study for Provoked VestibulodyniaCompletedNCT05342402Not applicable1 country
- A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With AllodyniaCompletedNCT00710554Phase 31 country
- Differences in Pain Processing Between Men and WomenCompletedNCT05031286Not applicable1 country
- Effect of S-ketamine in Cesarean Section Combined AnesthesiaCompletedNCT05414006Phase 41 country
- Effect of Daytime Variation on Postoperative Hyperalgesia Induced by OpioidsCompletedNCT052346971 country
- GentleCath Air (Urinary Self-catheterization) - Pain in Female Patients With Neurological Vesico-sphincter DisordersWithdrawnNCT04847609
- Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental ModelsTerminatedNCT01615510Phase 11 country
- Reducing Nocebo Effects on Pressure PainCompletedNCT05284383Not applicable1 country
- ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DISCECTOMYCompletedNCT05483647Not applicable1 country