Drug
Chlorhexidine clinical trials
Includes 110 studies of Chlorhexidine gluconate.
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Counted the way a researcher would: Chlorhexidine with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Chlorhexidine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 17 Sept 1976 · HIBICLENS · NDA 017768 (FDA, Drugs@FDA; as chlorhexidine gluconate)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
218 studies that test it; most in 2014 (22)
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2003 | 2 |
| 2004 | 4 |
| 2005 | 2 |
| 2006 | 3 |
| 2007 | 8 |
| 2008 | 9 |
| 2009 | 4 |
| 2010 | 7 |
| 2011 | 9 |
| 2012 | 12 |
| 2013 | 12 |
| 2014 | 22 |
| 2015 | 11 |
| 2016 | 8 |
| 2017 | 11 |
| 2018 | 13 |
| 2019 | 7 |
| 2020 | 7 |
| 2021 | 10 |
| 2022 | 8 |
| 2023 | 16 |
| 2024 | 12 |
| 2025 | 11 |
| 2026 | 9 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 31 · Other 189
Medline Industries (8) · Johns Hopkins Bloomberg School of Public Health (6) · Cairo University (5) · Solventum US LLC (4) · University of Santiago de Compostela (4) · Colgate Palmolive (4) · VA Office of Research and Development (3) · Washington University School of Medicine (3)
Often tested with
Tested in the same studies.
Mupirocin (15) · Povidone-Iodine (15) · 2-Propanol (6) · Triclosan (5) · Calcium Hydroxide (3) · Hydrogen Peroxide (3) · Cetylpyridinium (3) · Oils, Volatile (3)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 3 phase 3 studies under way
Chlorhexidine is the comparator. A study of two new drugs counts under both.
- 1Moringa · Misr International University · next primary completion Nov 2028
- 1Resveratrol · Al-Mustansiriyah University
Reaching primary completion within a year · 5, 1 in phase 3
Studies that test Chlorhexidine, phase 3 first.
- Jun 2027Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma:Phase 3 · Jiangxi Provincial Cancer Hospital
- Dec 2026The Effect of Different Types of Mouthwash on Extraction Sockets' HealingPhase 4 · University of Jordan
- Dec 2026Optimizing Infection Prophylaxis Prior to Shoulder SurgeryNot applicable · University of Washington
- Jun 2027Decolonization to Reduce After-Surgery Events of Surgical Site InfectionPhase 4 · University of California, Irvine
- Sep 2027Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis PatientsPhase 1/2 · Cairo University
Studies
Open first, then newest update. How each study uses Chlorhexidine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 220
- Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care PatientsEnrolling by invitationNot applicableUniversity of ZagrebNCT07868549Written as Chlorhexidine
- Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis PatientsNot yet recruitingPhase 1/2Cairo UniversityNCT07791238Written as Chlorhexidine 2%
- Decolonization to Reduce After-Surgery Events of Surgical Site InfectionRecruitingPhase 4University of California, IrvineNCT05586776Written as 4% Chlorhexidine Gluconate
- Infection Prophylaxis in Total Joint ReplacementRecruitingPhase 3Hamilton Health Sciences CorporationNCT06126614Written as Chlorhexidine Gluconate
- The Effect of Different Types of Mouthwash on Extraction Sockets' HealingRecruitingPhase 4University of JordanNCT06587880Written as Chlorhexidine Gluconate
- Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma:RecruitingPhase 3Jiangxi Provincial Cancer HospitalNCT07559877Written as 2% chlorhexidine
- Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative PainRecruitingNot applicableCukurova UniversityNCT07058727Written as Chlorhexidine
- Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal IndicesNot yet recruitingNot applicableRiyadh Elm UniversityNCT07307716Written as Chlorhexidine mouthwash (0.2%)
- Comparison of Inter-appointment Pain Reduction During Root Canal Treatment in Symptomatic Apical Periodontitis by Using Intracanal Medicaments; Chlorhexidine Gel and Single Antibiotic Paste NitrofurantoinEnrolling by invitationPhase 1/2Altamash Institute of Dental MedicineNCT07198919Written as Chlorhexidine gel
- The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to HealRecruitingPhase 3The Cooper Health SystemNCT07142408Written as Chlorhexidine gluconate (4%)
- Irrisept in Emergency General Surgery PatientsEnrolling by invitationPhase 4The University of Texas Health Science Center at TylerNCT07048899Written as Chlorhexidine
- Treatment of Periodontitis by Tulsi GelNot yet recruitingPhase 2/3Al-Azhar UniversityNCT06675578Written as Chlorhexidine gel
- Effectiveness of Povidone-Iodine Versus Chlorhexidine Gluconate Solutions in Reducing Microbial Contamination in Spinal Surgery Wounds During Intraoperative Soaking.RecruitingNot applicableNational Cheng-Kung University HospitalNCT06284174Written as Povidone-iodine solution; chlorhexidine gluconate
- A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC LevelsEnrolling by invitationNot applicableIslamic Azad University, SanandajNCT06875440Written as CHX mouthwash
- Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal SurgeryRecruitingPhase 3University of BirminghamNCT04256798Written as Chlorhexidine mouthwash
- Optimizing Infection Prophylaxis Prior to Shoulder SurgeryRecruitingNot applicableUniversity of WashingtonNCT06464770Written as Chlorhexidine Gluconate
- The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental ErosionNot yet recruitingNot applicableUniversity of PortsmouthNCT06171594Written as Chlorhexidine mouthwash
- Chlorhexidine and Garlic Extract as Potential Topical Virucidal Therapeutic Agents of Non-Genital WartsNot yet recruitingNot applicableAssiut UniversityNCT06077032Written as topical chlorhexidine (2%) solution
- Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of PeriodontitisNot yet recruitingPhase 1Assiut UniversityNCT05546788Written as chlorhexidine
- Local Delivery of Silk Fibroin and ChlorhexidineNot yet recruitingPhase 1Krishnadevaraya College of Dental Sciences & HospitalNCT06050863Written as Chlorhexidin
See all 220 studies that test Chlorhexidine →
Given beside what is tested · 17 — Chlorhexidine is usual care or a partner of the new treatment
- Chlorhexidine and/or Metronidazole Plus FB301 Pre-treatment TrialRecruitingPhase 2Freya Biosciences ApSNCT07481955Written as Chlorhexidine 0.5%
- Comparison of PRF and Corticosteroids in Impacted Third Molar SurgeryRecruitingNot applicableFinal International UniversityNCT07742826Written as Chlorhexidine
- Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline PlacementNot yet recruitingNot applicablediana garciaNCT07696156Written as Chlorhexidine Gluconate 2%
- Skin Preparation for Elective Foot and Ankle SurgeryRecruitingPhase 4University of Missouri-ColumbiaNCT05401292Written as Hibiclens
- Best Treatment Choice for Osteonecrosis of the JawRecruitingPhase 4Tim Van den WyngaertNCT04512638Written as Chlorhexidine mouthwash
- Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus LazertinibActive, not recruitingPhase 2Janssen Research & Development, LLCNCT06120140Written as Chlorhexidine
- Rose Bengal Electromagnetic Activation With Green Light for Infection ReductionCompletedPhase 3University of California, San FranciscoNCT05110001Written as Chlorhexidine Gluconate
- Comparison of Chlorhexidine and Hypochlorous Acid Mouthwash After Impacted Third Molar SurgeryCompletedNot applicableYuzuncu Yil UniversityNCT07466992Written as Chlorhexidine Gluconate Mouthwash
- S. Aureus Decolonization in HPN Patients.TerminatedNot applicableRadboud University Medical CenterNCT03173053Written as Chlorhexidine
- Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar SurgeryStatus unknownNot applicableTaibah UniversityNCT03844776Written as Chlorhexidine mouthwash
- Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High RiskCompletedPhase 2/3Dr. Krupa NCNCT04399161Written as Chlorhexidine mouthwash
- Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)CompletedPhase 2Johns Hopkins UniversityNCT01594827Written as 4% chlorhexidine gluconate liquid skin cleanser
- Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal TherapyTerminatedPhase 4Peter EickholzNCT01030666Written as 0.12% chlorhexidine gluconate solution
- Nitrous Oxide for Pain Management of Intrauterine Device (IUD) InsertionCompletedNot applicableUniversity of New MexicoNCT02391714Written as Chlorhexidine
- Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival RecessionsCompletedPhase 4Universidade Federal FluminenseNCT02433912Written as chlorhexidine gluconate
- Microsurgical Versus Conventional Semilunar Coronally Advanced FlapCompletedPhase 4Universidade Federal FluminenseNCT02433899Written as Chlorhexidine gluconate
- "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients.CompletedPhase 4Tatyasaheb Kore Dental CollegeNCT02154594Written as Chlorhexidine gluconate
As the comparator · 70 — what is tested is compared with Chlorhexidine
- Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for GingivitisNot yet recruitingNot applicableBahria UniversityNCT07892235Written as 0.2% Chlorhexidine Mouthwash
- Effectiveness of Pre-Procedural CPC and Zinc Mouthwash in Reducing Dental AerosolsNot yet recruitingPhase 4Colgate PalmoliveNCT07880509Written as 0.2% Chlorhexidine Mouthwash
- Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar OsteitisNot yet recruitingNot applicableKhyber Medical University PeshawarNCT07833176Written as Chlorhexidine
- Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With GingivitisNot yet recruitingPhase 1Cairo UniversityNCT07662226Written as Chlorohexidine 0.12% mouthwash
- Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine MouthwashNot yet recruitingPhase 2/3Misr International UniversityNCT04575948Written as Chlorhexidine mouthwash
- Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental ImplantsRecruitingNot applicableUniversity of ZagrebNCT07529444Written as 0.2% Chlorhexidine Gluconate
- Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B PeriodontitisNot yet recruitingNot applicableKafrelsheikh UniversityNCT07840716Written as Chlorhexidine gel
- Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-GrowthNot yet recruitingPhase 3University of BaghdadNCT07393802Written as Chlorhexidine Gluconate 0.12 % Mouthwash
- Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar ExtractionRecruitingNot applicableHarran UniversityNCT07180498Written as Chlorhexidine Gluconate 0.12% Mouthwash
- Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis.RecruitingPhase 3Al-Mustansiriyah UniversityNCT06882564Written as Chlorhexidine mouthwash (0.2%)
- Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCTRecruitingPhase 1Krishnadevaraya College of Dental Sciences & HospitalNCT06505759Written as chlorhexidine gel
- Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial ColonisationRecruitingPhase 4Charles University, Czech RepublicNCT06045429Written as Chlorhexidine mouthwash
- Silver Nanoparticle vs Chlorhexidine Mouthwashes for Reducing Streptococcus Mutans and Improving Salivary pH in ChildrenCompletedNot applicableAssiut UniversityNCT07728409Written as Chlorhexidine mouthwash (0.2%)
- St. John's Wort Oil Versus Chlorhexidine Mouthwash for Gingival Problems After Rapid Maxillary ExpansionCompletedNot applicableYuzuncu Yil UniversityNCT07882771Written as Chlorhexidine
- Clinical Outcomes of Different Mouth Rinses During Clear Aligner Orthodontic TherapyCompletedNot applicableManav Rachna International Institute of Research and StudiesNCT07865416Written as Chlorhexidine mouth rinse
- Comparative Evaluation of Oxygen-enriched and Chlorohexidine Mouthwashes as an Adjunct to Non-surgical Periodontal Therapy and Its Efficacy on Gingival Inflammation, Plaque Scores and Patient-reported OutcomesCompletedPhase 3Cairo UniversityNCT07861880Written as CHX mouthwash
- Chlorhexidine vs Essential Oil Mouthwash for Plaque ControlCompletedNot applicableRehman Medical Institute - RMINCT07822256Written as Chlorhexidine Gluconate Mouthwash
- Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCTCompletedNot applicableOman Dental CollegeNCT07535229Written as Chlorhexidine (0.2%)
- Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic TreatmentCompletedNot applicableKhyber Medical University PeshawarNCT07119840Written as Chlorhexidine mouthwash
- Comparison of Hyaluronic Acid and Chlorhexidine Gels for Traumatic Oral Ulcers During Fixed Orthodontic TreatmentCompletedNot applicableDow University of Health SciencesNCT07709455Written as Chlorhexidine gel
Showing 20 of 70.
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)WithdrawnOct 26, 2026NCT06712433
Codes
What other systems call Chlorhexidine · ClinicalTrials.gg INT007193
- MeSH (NLM) D002710ChlorhexidineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) R4KO0DY52LCHLORHEXIDINEConfirmed FDA, NLM, Wikidata
- RxNorm 2358Confirmed FDA, Wikidata
- Wikidata Q15646788chlorhexidineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C364ChlorhexidineOne source FDA
- DrugBank DB00878One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002710 | Chlorhexidine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | R4KO0DY52L | CHLORHEXIDINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2358 | — | Confirmed FDA, Wikidata |
| Wikidata | Q15646788 | chlorhexidine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C364 | Chlorhexidine | One source FDA |
| DrugBank | DB00878 | — | One source Wikidata |
Also registered as chlorhexidine acetate (UNII 5908ZUF22Y · RxNorm 133054) and chlorhexidine hydrochloride (UNII E64XL9U38K · RxNorm 2361).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.