Periodontal Diseases clinical trials
The registry lists 867 studies for Periodontal Diseases across more than 10 countries. 189 are recruiting or about to start. 406 of them are mainly about Periodontal Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 16 narrower conditions too, such as Periodontitis: 4,096 studies, 868 open.
ClinicalTrials.gov finds 4,112 studies for Periodontal Diseases. How that becomes 866 here
This page counts the studies the registry files under Periodontal Diseases, and those it files under no condition that list Periodontal Diseasesthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 4,112Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −3,093Filed under a narrower condition, counted on its own pagePeriodontitis 942 · Gingivitis 415 · Gingival Recession 394 · Peri-Implantitis 277 · Alveolar Bone Loss 246 · Chronic Periodontitis 242 · 10 more
- −11List Periodontal Diseases as a condition, but the registry did not file them under itMost often written as “Diabetes Mellitus With Periodontal Disease” (3), “Periodontal Diseases Inflammation” (2), and “Patients With Periodontal Disease” (1). The registry filed 9 of them under no condition at all, and the others under other conditions only, most often Malocclusion, Angle Class I (1) and Diabetes Mellitus, Type 2 (1).
- −142Match it another way8 name it in the title and 134 by a synonym or other text the search reads.
- 866The count on this page
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Status
Who runs them
University of Sao Paulo (23) · Cairo University (17) · University of Pavia (13) · Izmir Katip Celebi University (11) · Necmettin Erbakan University (11) · Abant Izzet Baysal University (10) · Saglik Bilimleri Universitesi (10) · Ain Shams University (10)
What is being tested here
Drugs under test in Periodontal Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery · Aesculap AG
- Nov 2026ABX Versus CHX in NSPT · University of Roma La Sapienza
- Nov 2026Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary Syndrome · Meenakshi Ammal Dental College and Hospital
- Nov 2026NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNE · Alanya Alaaddin Keykubat University
- Nov 2026Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial · Zeyad Nazar
- Nov 2026Markers of Bone Destruction and Oxidative Stress in Peri-implantitis · Saglik Bilimleri Universitesi
- Nov 2026HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy · Ömer Faruk Okumuş
- Nov 2026Oral Health and Systemic Diseases: Survey of General Practitioners · University of Roma La Sapienza
- Dec 2026Antibiotic Resistance Genes in Periodontitis · Istanbul University
- Dec 2026Hyaluronic Acid and Polynucleotides for Supra-bony Defects · Queen Mary University of London
Who these studies take
Of the 101 Periodontal Diseases studies recruiting now, 47 (47%) set no upper age limit and 42 (42%) stop at 75 or younger. 5 (5%) take children under 18. 6 (6%) are for women only and 0 (0%) for men only; 58 (57%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (3%) | 2 (2%) |
| 18 | 73 (72%) | 67 (66%) |
| 30 | 91 (90%) | 85 (84%) |
| 40 | 95 (94%) | 89 (88%) |
| 50 | 91 (90%) | 88 (87%) |
| 65 | 82 (81%) | 79 (78%) |
| 75 | 63 (62%) | 60 (59%) |
| 85 | 52 (51%) | 49 (49%) |
Across all 867 studies, recruiting or not: 55% stop at 75 or younger and 43% at 65; 10% take children; 6% are for women only and 1% for men only; 58% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Periodontal Diseases studies take
Of 24 phase 4 interventional studies under Periodontal Diseases, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 9 mo6–17 · 14 studies | — | — |
| Phase 3 | 6 mo2–23 · 19 studies | — | — |
| Phase 4 | 17 mo10–45 · 24 studies | — | — |
| Interventional, no phase | 13 mo8–27 · 331 studies | — | 13 mo8–27 · 312 studies |
| Observational | 13 mo7–32 · 83 studies | — | 13 mo7–30 · 79 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Newly registered10
- The Effect of Using Plaque-disclosing Tablets on the Effectiveness of Toothbrushing and Gingival Health in ChildrenNov 9, 2026NCT07924423
- Timing of Oral Hygiene Improvement Relative to Subgingival InstrumentationNov 3, 2026NCT07914400
- Effects Of Periodontal Therapy In Patients With Inflammatory Bowel DiseaseOct 30, 2026NCT07905859
- NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNEOct 23, 2026NCT07892638
- Antibiotic Resistance Genes in PeriodontitisOct 21, 2026NCT07887204
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- Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in GingivitisOct 20, 2026NCT07882394
- Comparision of Enzymatic and Active Salt ToothpasteOct 19, 2026NCT07880483
- Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 YearsOct 19, 2026NCT07880717
- Prevalence of Caries and Periodontal Disease and Their Correlation in a Dental School in EgyptOct 19, 2026NCT07880808
- Evaluation of MTHFR Gene Polymorphism and Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis IndividualsOct 14, 2026NCT07873385
Studies
Recruiting first, then most recently updated. Showing 50 of 867. Browse all 867 → or search them.
- NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal SurgeryRecruitingNCT05813236Not applicable1 country
- Thermosensitive Hyaluronic Gel With Octenidine as an Adjunctive to Subgingival InstrumentationRecruitingNCT07725913Not applicable1 country
- Candida Albicans in Syrian Patients With PeriodontitisRecruitingNCT075748271 country
- Evaluation of the Impact of Periodontitis and Its Treatment on Swallowing Functions and Oral Quality of LifeRecruitingNCT07651579Not applicable1 country
- Effects Of Periodontal Therapy In Patients With Inflammatory Bowel DiseaseRecruitingNCT079058591 country
- Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based TrialNot yet recruitingNCT07553286Phase 3
- Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)RecruitingNCT015686971 country
- Education-Based Oral Health Promotion Intervention During Pregnancy: Implementation Protocol in BangladeshNot yet recruitingNCT07507045Not applicable1 country
- Oral Health Intervention in Adult Primary CareRecruitingNCT06555029Not applicable1 country
- Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in GingivitisRecruitingNCT07882394Not applicable1 country
- Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 YearsRecruitingNCT078807171 country
- Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic PatientsRecruitingNCT06486012Not applicable1 country
- CHEER Oral Health in Pregnancy StudyRecruitingNCT07377344Not applicable1 country
- Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary SyndromeNot yet recruitingNCT07504744
- Retinal and Choroidal Changes in Periodontal DiseaseNot yet recruitingNCT078569011 country
- The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered Toothbrush in Older Individuals With Periodontitis and Mild Cognitive Impairment.RecruitingNCT07166224Not applicable1 country
- Comparison of Autologous Tooth and Bovine Xenograft in Periodontal Healing After Mandibular Third Molar ExtractionRecruitingNCT07824518Not applicable1 country
- Markers of Bone Destruction and Oxidative Stress in Peri-implantitisRecruitingNCT073978841 country
- Photodynamic Therapy as an Adjunct in Periodontal TreatmentEnrolling by invitationNCT07633405Not applicable1 country
- Dental Loupe Versus Dental Operating Microscope for Non-Surgical Periodontal TreatmentRecruitingNCT07822269Not applicable1 country
- Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic GraftsRecruitingNCT07146776Not applicable1 country
- Serum Inflammatory Protein Concentration During Dental TreatmentRecruitingNCT074689291 country
- Locally Delivered Melatonin Gel in Management of Stage II Grade B PeriodontitisNot yet recruitingNCT07813936Not applicable1 country
- Xylitol and the Prevention of Periodontal Disease and Preterm Birth TrialRecruitingNCT07424846Phase 2/31 country
- Laser Assisted Open Flap DebridementNot yet recruitingNCT07807215Not applicable1 country
- Integrated Diabetes and Oral Health Care in OmanNot yet recruitingNCT07809477Not applicable
- Oral Hygiene Assistance Training ProgramNot yet recruitingNCT07807397Phase 4
- Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal TreatmentNot yet recruitingNCT07803484Phase 31 country
- Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With DiabetesEnrolling by invitationNCT07619729Phase 41 country
- Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis PatientsNot yet recruitingNCT07791238Phase 1/2
- Periodontal Status and Thyroid Markers in PregnancyNot yet recruitingNCT077876761 country
- Exploration of the Utility of Dental-dedicated MRI for DentistryRecruitingNCT069481621 country
- Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal TherapyNot yet recruitingNCT07770906Not applicable
- Evaluation of Toothbrush BristlesRecruitingNCT07306026Not applicable1 country
- Digital vs Conventional VFR in Post-Orthodontic RetentionNot yet recruitingNCT07760935Not applicable
- Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell CarcinomaNot yet recruitingNCT077458031 country
- Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony DefectsNot yet recruitingNCT07737678Phase 1/2
- Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic BiomarkersNot yet recruitingNCT07699978
- Bacterial Diversity Study Using 16S rRNA Sequencing of Periodontal Samples From Patients With Orthodontic RetainersRecruitingNCT07718061Not applicable1 country
- Probiotic Response in Periodontal DiseaseNot yet recruitingNCT07718074Not applicable
- Short Implants Produced by Additive Manufacturing in the Posterior Jaws: 3 Years of Follow-upEnrolling by invitationNCT076884211 country
- This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis PatientsRecruitingNCT07707063Phase 41 country
- Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III PeriodontitisRecruitingNCT07673185Not applicable1 country
- Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With GingivitisNot yet recruitingNCT076897861 country
- Bio-Descaling Toothpaste for Dental Calculus ReductionNot yet recruitingNCT07689071Not applicable
- Short Implants in Unitary Implant-supported Rehabilitations in the Posterior Maxilla and Mandible: 5 Years of Follow-upNot yet recruitingNCT076884081 country
- 3D Printed Customized Bone Graft for Alveolar Regeneration: Longitudinal Cohort EvaluationNot yet recruitingNCT07405918
- Longitudinal Evaluation of Several Modalities of Treatment of Peri-implantitis: 5 to 23 Years Follow-upNot yet recruitingNCT07684001
- Autologous Platelet Concentrate (APC) in Intrabony DefectsRecruitingNCT04254861Not applicable1 country
- A Person-centered, Theory-based, Intervention - Method Development Through the Integration of Digital Technology.Enrolling by invitationNCT07306117Not applicable1 country