Pneumonia, Ventilator-Associated clinical trials
The registry lists 420 studies for Pneumonia, Ventilator-Associated across more than 10 countries. 85 are recruiting or about to start. 340 of them are mainly about Pneumonia, Ventilator-Associated (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Assiut University (10) · Assistance Publique - Hôpitaux de Paris (9) · Pfizer (8) · Fondation Hôpital Saint-Joseph (5) · University Hospital, Lille (5) · Ain Shams University (5) · University of Thessaly (4) · Region Skane (4)
What is being tested here
Drugs under test in Pneumonia, Ventilator-Associated studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Colistin | 2 | 3 | 7 |
| Colistinmethanesulfonic acid | 2 | 3 | 4 |
| Amikacin | 1 | 2 | 7 |
| Tobramycin | 1 | 0 | 2 |
| Bacillus clausii | 1 | 0 | 1 |
| Cetylpyridinium | 1 | 0 | 1 |
| Acyclovir | 1 | 1 | 1 |
| Interferon Gamma | 1 | 1 | 1 |
| Doripenem | 0 | 4 | 9 |
| Chlorhexidine | 0 | 1 | 7 |
Drug classes tested here Beta-lactamase inhibitors 7 · Statins 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jul 2027Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients · Phase 3 · Hospices Civils de Lyon
- Nov 2026Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates. · Dalia Mohamed Salah
- Nov 2026Optimizing Enteral Nutrition Regimen for Critically Ill Patients · Hamad Medical Corporation
- Nov 2026Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units · Hospital do Coracao
- Dec 2026Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols · Alexandria University
- Dec 2026Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia · Centre Hospitalier Intercommunal Aix-Pertuis
- Dec 2026A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children · Johns Hopkins University
- Dec 2026Perpetual Observational Study - Ventilator Associated Pneumonia · European Clinical Research Alliance for Infectious Diseases (ECRAID)
- Dec 2026Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury · Southeast University, China
- Dec 2026Biomarkers for Ventilator-associated Pneumonia · Region Skane
Who these studies take
Of the 48 Pneumonia, Ventilator-Associated studies recruiting now, 37 (77%) set no upper age limit and 6 (13%) stop at 75 or younger. 6 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (6%) | 3 (6%) |
| 18 | 43 (90%) | 43 (90%) |
| 30 | 42 (88%) | 42 (88%) |
| 40 | 42 (88%) | 42 (88%) |
| 50 | 42 (88%) | 42 (88%) |
| 65 | 42 (88%) | 42 (88%) |
| 75 | 42 (88%) | 42 (88%) |
| 85 | 41 (85%) | 41 (85%) |
Across all 420 studies, recruiting or not: 16% stop at 75 or younger and 12% at 65; 18% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pneumonia, Ventilator-Associated studies take
Of 16 phase 3 interventional studies under Pneumonia, Ventilator-Associated, half reached primary completion within 43 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 43 mo26–59 · 16 studies | — | — |
| Interventional, no phase | 20 mo10–36 · 82 studies | — | 20 mo10–38 · 81 studies |
| Observational | 20 mo12–38 · 63 studies | — | 20 mo12–38 · 63 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Effect of Two Oral Care Methods on Oral Flora and VAP in Mechanically Ventilated PatientsNov 9, 2026NCT07283380
- Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated PneumoniaOct 13, 2026NCT07403474
Stopped1
- LUNG INFECTION IN ICU (LUNG-I3)TerminatedOct 30, 2026NCT06073834
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 420. Browse all 420 → or search them.
- Effect of Two Oral Care Methods on Oral Flora and VAP in Mechanically Ventilated PatientsRecruitingNCT07283380Not applicable1 country
- Traditional Chinese Medicine in Multidrug-Resistant Bacterial PneumoniaNot yet recruitingNCT077260951 country
- Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGSNot yet recruitingNCT04955821
- EaRly impAct theraPy With Ceftazidime-avibactam Via rapID DiagnosticsRecruitingNCT05979545Phase 47 countries
- Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention ProtocolsNot yet recruitingNCT07866027Not applicable1 country
- Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated PneumoniaRecruitingNCT06743529Not applicable2 countries
- Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain InjuryNot yet recruitingNCT07883083Not applicable1 country
- Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated PneumoniaRecruitingNCT07403474Phase 41 country
- Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated PneumoniaNot yet recruitingNCT06488794Phase 2/3
- Role of Inhaled Polymyxin as an Adjunct to Intravenous Therapy in Multidrug Resistant Ventilator-associated Pneumonia in Stroke PatientsNot yet recruitingNCT07865871Early Phase 1
- BIS in ICU Interventional StudyNot yet recruitingNCT07350122Not applicable
- Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.RecruitingNCT07255742Not applicable1 country
- Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated PneumoniaNot yet recruitingNCT07856355Phase 41 country
- Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care UnitRecruitingNCT07848165Not applicable1 country
- B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)RecruitingNCT074367801 country
- Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)RecruitingNCT07585604Not applicable1 country
- Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled TrialNot yet recruitingNCT07820501Not applicable
- Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain InjuryRecruitingNCT06819462Not applicable1 country
- Perpetual Observational Study - Ventilator Associated PneumoniaRecruitingNCT0571925913 countries
- Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated PneumoniaRecruitingNCT05915663Not applicable1 country
- Study on the Safety and Efficacy of Polymyxin E2 Methanesulfonate for Injection in the Treatment of Hospital-Acquired Bacterial Pneumonia/Ventilator-Associated Bacterial Pneumonia Caused by Carbapenem-Resistant Gram-Negative BacteriaRecruitingNCT07512596Phase 21 country
- Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective RegimensRecruitingNCT06554327Not applicable1 country
- Immunity Markers in Intensive Care Patients and Ventilator-associated PneumoniaRecruitingNCT066070551 country
- Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Immunocompromised Patients With Hospital-acquired Pneumonia Requiring Mechanical VentilationRecruitingNCT05405491Not applicable1 country
- Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion SuctioningNot yet recruitingNCT06113939Phase 41 country
- Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BALRecruitingNCT06134492Phase 31 country
- Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU PatientsNot yet recruitingNCT076968971 country
- Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care UnitRecruitingNCT06000761Not applicable1 country
- Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU PatientsRecruitingNCT05843786Phase 31 country
- ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated PneumoniaRecruitingNCT072458883 countries
- Biomarkers for Ventilator-associated PneumoniaRecruitingNCT051171253 countries
- National Surveillance and Prevention of Neonatal VAPNot yet recruitingNCT071097911 country
- Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated TracheobronchitisNot yet recruitingNCT07665788Phase 31 country
- A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill ChildrenEnrolling by invitationNCT049878401 country
- Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled TrialRecruitingNCT06834971Not applicable1 country
- Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly PatientsRecruitingNCT075512581 country
- EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)Not yet recruitingNCT07267624Not applicable1 country
- Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care UnitsRecruitingNCT07233837Not applicable1 country
- Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRERecruitingNCT072685601 country
- Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled TrialNot yet recruitingNCT07463339Phase 2
- PK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured PatientsNot yet recruitingNCT074504041 country
- Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit in BangladeshNot yet recruitingNCT07299799Not applicable2 countries
- Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income CountriesNot yet recruitingNCT07397364Not applicable1 country
- Macrophage Programing in Acute Lung Injury: MiniBALRecruitingNCT05767671Not applicable1 country
- Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated PatientsRecruitingNCT07375667Not applicable1 country
- TRacheal Cuff PRessure Evaluation StudyNot yet recruitingNCT06848010Not applicable1 country
- Effect of Implementing Evidence-based Practice and Nurse's Behavior Change on Quality of Care in Intensive Care Unit: Focus on Ventilator Associated Pneumonia in a Tertiary Hospital in BangladeshRecruitingNCT06624540Not applicable2 countries
- VAP Incidence and Adequation to SRLF 2017 Diagnostic Among an Intensive Care Medicine Service for the Period 2022 à 2024RecruitingNCT071818241 country
- Optimizing Enteral Nutrition Regimen for Critically Ill PatientsNot yet recruitingNCT07270939Not applicable
- Reduction of the Incidence of NAV in Neonatal Units (INBERNAV-Neo)RecruitingNCT072400381 country