Dental Plaque clinical trials
The registry lists 352 studies for Dental Plaque across more than 10 countries. 60 are recruiting or about to start. 220 of them are mainly about Dental Plaque (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Colgate Palmolive (34) · HALEON (9) · Koite Health Oy (8) · GlaxoSmithKline (7) · Marmara University (7) · University of Pavia (6) · King Abdullah University Hospital (5) · Church & Dwight Company, Inc. (5)
What is being tested here
Drugs under test in Dental Plaque studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis. · Phase 3 · Colgate Palmolive
- Jan 2027Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems · Phase 3 · Colgate Palmolive
- Nov 2026Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem · Unilever R&D
- Nov 2026A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride · HALEON
- Nov 2026Oil Pulling Reduction · The University of Texas Health Science Center at San Antonio
- Dec 2026Powered vs. Manual Toothbrushing in Stage 3-4 Periodontitis · University of L'Aquila
- Dec 2026The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes · King Abdullah University Hospital
- Dec 2026Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons · Koite Health Oy
- Dec 2026Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns · University Hospital, Basel, Switzerland
- Dec 2026Antibacterial Photodynamic Therapy in the Management of Peri-implantitis · Koite Health Oy
Who these studies take
Of the 35 Dental Plaque studies recruiting now, 10 (29%) set no upper age limit and 20 (57%) stop at 75 or younger. 14 (40%) take children under 18. 2 (6%) are for women only and 0 (0%) for men only; 22 (63%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (14%) | 5 (14%) |
| 18 | 26 (74%) | 24 (69%) |
| 30 | 25 (71%) | 23 (66%) |
| 40 | 24 (69%) | 22 (63%) |
| 50 | 22 (63%) | 21 (60%) |
| 65 | 22 (63%) | 21 (60%) |
| 75 | 15 (43%) | 14 (40%) |
| 85 | 15 (43%) | 14 (40%) |
Across all 352 studies, recruiting or not: 69% stop at 75 or younger and 57% at 65; 30% take children; 2% are for women only and 2% for men only; 78% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Dental Plaque studies take
Of 20 phase 3 interventional studies under Dental Plaque, half reached primary completion within 2 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 2 mo1–4 · 20 studies | — | — |
| Interventional, no phase | 6 mo2–14 · 178 studies | 2 mo1–8 · 45 studies | 7 mo3–16 · 133 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Results posted1
Newly registered9
- AI-Based Caries and Plaque Detection and Caries Risk Prediction in ChildrenNov 10, 2026NCT07929753
- The Effect of Using Plaque-disclosing Tablets on the Effectiveness of Toothbrushing and Gingival Health in ChildrenNov 9, 2026NCT07924423
- Comparison of the Effectiveness of Oral Hygiene Motivation Methods Among Dentistry and Psychology StudentsNov 4, 2026NCT07917286
- Comparison of Model-Based and Video-Based Toothbrushing Instruction in ChildrenNov 2, 2026NCT07909213
- Effectiveness of Personalized Digital Oral Health Intervention in Patients With Fixed Orthodontic Appliances.Nov 2, 2026NCT07910851
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- Effect of Xylitol- Versus Erythritol-Sweetened Mints on Plaque ATP-Bioluminescence ReadingsOct 28, 2026NCT07902323
- Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for GingivitisOct 23, 2026NCT07892235
- Essential Oil Mouthwash - Oral HygieneOct 21, 2026NCT07887074
- Comparision of Enzymatic and Active Salt ToothpasteOct 19, 2026NCT07880483
Studies
Recruiting first, then most recently updated. Showing 50 of 352. Browse all 352 → or search them.
- AI-Based Caries and Plaque Detection and Caries Risk Prediction in ChildrenNot yet recruitingNCT079297531 country
- Effectiveness of Personalized Digital Oral Health Intervention in Patients With Fixed Orthodontic Appliances.Not yet recruitingNCT07910851Not applicable
- Effect of Xylitol- Versus Erythritol-Sweetened Mints on Plaque ATP-Bioluminescence ReadingsNot yet recruitingNCT07902323Not applicable
- Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for GingivitisNot yet recruitingNCT07892235Not applicable1 country
- The Study to Evaluate the Plaque Control and Anti-Gingivitis Efficacy of a Toothpaste in Chinese PopulationRecruitingNCT07816406Not applicable1 country
- Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial ToothpasteNot yet recruitingNCT07850232Not applicable1 country
- A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous FluorideRecruitingNCT07842042Not applicable1 country
- Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine MouthwashNot yet recruitingNCT04575948Phase 2/3
- 3D Volumetric Plaque Assessment on Teeth, Composite Restorations, and Ceramic Veneers Using an Intraoral ScannerNot yet recruitingNCT074216871 country
- Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum ProblemsRecruitingNCT07842991Phase 31 country
- Clinical Assessment of the Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual ToothbrushNot yet recruitingNCT07805148Not applicable1 country
- In Situ Evaluation of Plaque Accumulation on Innovative Nanostructured Metal Implant SurfacesNot yet recruitingNCT07784803Not applicable
- Oil Pulling ReductionRecruitingNCT07706647Not applicable1 country
- Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual ToothbrushRecruitingNCT07779564Not applicable1 country
- Digital vs Conventional VFR in Post-Orthodontic RetentionNot yet recruitingNCT07760935Not applicable
- Investigation of Biofilm Formation on Temporary push-on Rings of Implant CrownsRecruitingNCT05122897Not applicable1 country
- Antibacterial Photodynamic Therapy in the Management of Peri-implantitisRecruitingNCT06017817Not applicable1 country
- Plaque Removal Efficiency in Children With Specific Learning DisabilitiesRecruitingNCT07611942Not applicable1 country
- Intraoral Scan and CBCT-Aided Diagnosis of Dental Plaque and CariesRecruitingNCT075552231 country
- Disclosing Agents as Photosensitizers in aPDT for Biofilm Control in ChildrenNot yet recruitingNCT07539181Not applicable
- Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival BleedingNot yet recruitingNCT07499115Phase 31 country
- Clinical Evaluation of the NeoPill Device for Reduction of Oral Bacterial Load in Patients With Fixed Orthodontic AppliancesRecruitingNCT07355400Not applicable1 country
- Mobile Application Push Notification in Improving Oral Hygiene Behaviour in Adolescent Orthodontic PatientsRecruitingNCT07288853Not applicable1 country
- Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During PregnancyRecruitingNCT07029360Not applicable1 country
- Lactoferrin-Based Oral Care for Periodontal Health in PregnancyRecruitingNCT07069140Not applicable1 country
- Hydroxyapatite Toothpastes and Enamel Remineralization:RecruitingNCT07069218Not applicable1 country
- The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth WashesRecruitingNCT07364565Not applicable1 country
- Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic BracketsNot yet recruitingNCT07355322Not applicable1 country
- Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School ChildrenRecruitingNCT07356869Not applicable1 country
- Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal IndicesNot yet recruitingNCT07307716Not applicable1 country
- Imaging-based Assessment of Oral Biofilm and Gingival HealthRecruitingNCT05470023Not applicable1 country
- Novel Dental Gel as an Adjunct to Scaling and Root PlaningRecruitingNCT05384132Not applicable1 country
- SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in ChildrenRecruitingNCT07181967Not applicable1 country
- Oral Changes With Caloric and no Caloric SweetenersRecruitingNCT05852145Phase 1/21 country
- Assessment of Dental Pathologies Using Digital ToolsRecruitingNCT072055882 countries
- Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.RecruitingNCT07180849Not applicable1 country
- Evaluation of a Novel Dual-Headed Toothbrush Design for Periodontal Health: Split-Mouth Randomized Blind Clinical TrialRecruitingNCT07030088Not applicable1 country
- 4-day Plaque Accumulation Model Evaluating Compound Containing GumRecruitingNCT06984744Not applicable1 country
- Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly PersonsRecruitingNCT06576063Not applicable1 country
- Bacteria in Dental Plaque and Atheroma PlaqueRecruitingNCT071005741 country
- Effectiveness of Plaque Score Detection TechniquesRecruitingNCT065118301 country
- Powered vs. Manual Toothbrushing in Stage 3-4 PeriodontitisEnrolling by invitationNCT06980714Not applicable1 country
- Intra Oral Scan and CBCT Aided Diagnosis of Dental Plaque and CariesNot yet recruitingNCT069453541 country
- AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young AdultsNot yet recruitingNCT06897033Not applicable
- Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical TrialRecruitingNCT06453005Not applicable1 country
- Adjunctive Oral Hygiene Aids in Reducing Oral Hygiene Parameters Among Orthodontic PatientsNot yet recruitingNCT06779279Not applicable1 country
- Comparative Accuracy of AI Models and Clinical Assessment for Dental Plaque Detection in ChildrenNot yet recruitingNCT067601041 country
- Probiotic Treatment of Orthodontic PatientsRecruitingNCT06751979Not applicable1 country
- Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear AlignersRecruitingNCT06685016Not applicable1 country
- An Investigation of the Efficacy of OHEM for Improving Oral Hygiene in ChildrenNot yet recruitingNCT06356402Not applicable1 country