An interventional study of Placebo gel (Methyle cellulose) and Active oxygen gel in Stage II Grade B Periodontitis, sponsored by Kafrelsheikh University. Not yet recruiting. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-09-25.
Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Treatment
This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B periodontitis.Sixty participants will be randomly assigned to one of three parallel groups: SRP with placebo gel, SRP with active oxygen gel, or SRP with chlorhexidine gel. The study will evaluate changes in probing pocket depth, clinical attachment level, gingival index, plaque index, and gingival crevicular fluid tumor necrosis factor alpha levels at baseline and follow-up visits to compare the effects of the three treatment approaches.
1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.
This study's planned enrollment of 60 is above the median of 44 across 846 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Kafrelsheikh University is the lead sponsor of 294 studies on the registry; 114 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Scaling and root planing followed by locally delivered placebo gel ( Methyl Cellulose Gel)
Drug: Placebo gel (Methyle cellulose)
Scaling and root planing followed by locally delivered active oxygen gel
Drug: Active oxygen gel
Scaling and root planing followed by locally delivered chlorhexidine gel
Drug: Chlorhexidine gel
Methyle cellulose placebo gel administered subgingivally as adjunct to scaling and root planing
active oxygen gel administered subgingivally as adjunct to scaling and root planing
Chlorhexidine gel administered subgingivaly as adjunct to scaling and root planing
Clinical attachment level
Clinical attachment level (CAL) will be measured in millimeters using UNC-15 periodontal probe from cementoenamel junction (CEJ) to the base of the pocket at baseline, 1, 3, and 6 months post-treatment.
Time frame: Baseline, 1,3, and 6 months
Tumor necrosis factor alpha (TNF-alpha)
Tumor necrosis factor alpha levels in gingival crevicular fluid will be measured pg/ml using enzyme-linked immunosorbent assay (ELISA)
Time frame: Baseline, 1, and 3 months.
Probing pocket depth (PPD)
Probing pocket depth (PPD) will be measured in millimeters using UNC-15 periodontal probe assessed at baseline, 1, 3, and 6 months.
Time frame: Baseline, 1, 3, and 6 months
Gingival index (GI)
Gingival index (GI) will be assessed using the Silness and Löe Gingival Index at baseline 1, 3, and 6 months post-treatment
Time frame: Baseline, 1, 3, and 6 months.
Plaque index (PI)
Plaque index will be assessed using the Silness and Löe plaque index at baseline, 1, 3, and 6 months post-treatment.
Time frame: Baseline, 1, 3, and 6 months.
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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