Peri-Implantitis clinical trials
The registry lists 322 studies for Peri-Implantitis across more than 10 countries. 88 are recruiting or about to start. 287 of them are mainly about Peri-Implantitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Status
Who runs them
Universitat Internacional de Catalunya (15) · Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain (13) · Universidad Complutense de Madrid (8) · University of Michigan (7) · Università Vita-Salute San Raffaele (7) · Gazi University (6) · University of Barcelona (6) · Aristotle University Of Thessaloniki (5)
What is being tested here
Drugs under test in Peri-Implantitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Study on the Treatment of Dental Implants Using the AmbiJet System for Peri-implantitis and Peri-implant Mucositis · Freiburger Medizintechnik GmbH
- Nov 2026Surgical Treatment of Peri-implantitis Defects · Abeer Hakam
- Dec 2026Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitis · National and Kapodistrian University of Athens
- Dec 2026Natural Bioactive Gel for Peri-Implantitis · University of Pavia
- Dec 2026Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · University of Bern
- Dec 2026Peri-implantitis Treatment With Chitosan Brush · Hacettepe University
- Dec 2026Air-polishing in the Treatment of Peri-implantitis · Göteborg University
- Dec 202620-25 Year Follow-Up on Regenerative Bone Procedures for Peri-Implantitis · Kristianstad University
- Dec 2026Diagnostic Accuracy of Large Language Models for Peri-Implant Marginal Bone Loss on Panoramic Radiographs · Ankara University
- Dec 2026Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns · University Hospital, Basel, Switzerland
Who these studies take
Of the 48 Peri-Implantitis studies recruiting now, 26 (54%) set no upper age limit and 9 (19%) stop at 75 or younger. 7 (15%) take children under 18. 0 (0%) are for women only and 1 (2%) for men only; 25 (52%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (15%) | 7 (15%) |
| 18 | 42 (88%) | 43 (90%) |
| 30 | 46 (96%) | 47 (98%) |
| 40 | 47 (98%) | 48 (100%) |
| 50 | 47 (98%) | 48 (100%) |
| 65 | 46 (96%) | 47 (98%) |
| 75 | 41 (85%) | 42 (88%) |
| 85 | 32 (67%) | 32 (67%) |
Across all 322 studies, recruiting or not: 23% stop at 75 or younger and 13% at 65; 10% take children; 1% are for women only and 2% for men only; 54% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Peri-Implantitis studies take
Of 126 interventional studies with no phase under Peri-Implantitis, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 26 mo12–40 · 126 studies | — | 26 mo12–46 · 119 studies |
| Observational | 17 mo8–77 · 35 studies | — | 17 mo8–77 · 33 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus FluidNov 3, 2026NCT07280754
- Access to Probing and Peri-implant DiseasesOct 13, 2026NCT07557459
Newly registered2
- Effect of Customized Versus Stock Healing Abutments on Peri-Implant Soft TissueOct 30, 2026NCT07906899
- Diagnostic Accuracy of Large Language Models for Peri-Implant Marginal Bone Loss on Panoramic RadiographsOct 30, 2026NCT07907900
Studies
Recruiting first, then most recently updated. Showing 50 of 322. Browse all 322 → or search them.
- Effect of Customized Versus Stock Healing Abutments on Peri-Implant Soft TissueNot yet recruitingNCT07906899Not applicable
- Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus FluidRecruitingNCT072807541 country
- Diagnostic Accuracy of Large Language Models for Peri-Implant Marginal Bone Loss on Panoramic RadiographsNot yet recruitingNCT079079001 country
- Access to Probing and Peri-implant DiseasesRecruitingNCT075574591 country
- ATR-FTIR and Raman Spectroscopy of Peri-Implant Crevicular Fluid in Peri-ImplantitisNot yet recruitingNCT07864233
- Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental ImplantsRecruitingNCT07529444Not applicable1 country
- Investigation of Macrophage Polarization in Peri-implant Health and Peri-implantitisRecruitingNCT075694321 country
- Non-surgical Treatment of Peri-implant Pockets With H42RecruitingNCT076804911 country
- Timing of Success Evaluation After Flapless Treatment of Peri-ImplantitisNot yet recruitingNCT078446421 country
- Impact of Smoking on Immune Responses in Peri-implant Health and DiseaseRecruitingNCT077501711 country
- Reconstructive Treatment of Peri-implantitis With Electrolytic Decontamination Versus Titanium BrushesNot yet recruitingNCT07814391Early Phase 1
- Peri-implantitis Management: Surgical and Maintenance OutcomesRecruitingNCT07550127Not applicable1 country
- Titanium Particle Release Across Non-Surgical Peri-implantitis TherapiesNot yet recruitingNCT07811921Not applicable
- Intaglio Surface of Full-arch Implant Supported ProsthesisEnrolling by invitationNCT066360971 country
- Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony DefectsEnrolling by invitationNCT078093341 country
- Air-polishing in the Treatment of Peri-implantitisEnrolling by invitationNCT04847648Not applicable1 country
- Evaluation of the Effects of Routine Phase I Periodontal Therapy on Clinical Parameters and Levels of Gremlin-1, CTHRC1, and Tenascin-C in Gingival Crevicular Fluid and Peri-Implant Sulcular Fluid in Individuals With Periodontitis and Peri-ImplantitisNot yet recruitingNCT077971271 country
- Regenerative Treatment of Peri-implantitisEnrolling by invitationNCT06153212Not applicable1 country
- Effect of Metallic Particles on the Progression of Peri-ImplantitisNot yet recruitingNCT07792499
- Investigation of Biofilm Formation on Temporary push-on Rings of Implant CrownsRecruitingNCT05122897Not applicable1 country
- Antibacterial Photodynamic Therapy in the Management of Peri-implantitisRecruitingNCT06017817Not applicable1 country
- Study on the Treatment of Dental Implants Using the AmbiJet System for Peri-implantitis and Peri-implant MucositisRecruitingNCT07722715Not applicable1 country
- Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen MembraneNot yet recruitingNCT07032259Not applicable
- Patient Perspectives Throughout Peri-Implantitis TreatmentNot yet recruitingNCT076943231 country
- Natural Bioactive Gel for Peri-ImplantitisRecruitingNCT07088679Not applicable1 country
- Longitudinal Evaluation of Several Modalities of Treatment of Peri-implantitis: 5 to 23 Years Follow-upNot yet recruitingNCT07684001
- Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without ImplantoplastyEnrolling by invitationNCT06063876Not applicable1 country
- 20-25 Year Follow-Up on Regenerative Bone Procedures for Peri-ImplantitisEnrolling by invitationNCT066485641 country
- Electrolytic Surface Decontamination in the Surgical Treatment of Peri-implantitis: A Randomized Clinical TrialNot yet recruitingNCT07644975Not applicable1 country
- Occurrence of Peri-Implant Complications: A Multifactorial Cross-Sectional StudyRecruitingNCT076389691 country
- Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular ImplantsNot yet recruitingNCT07590037Not applicable1 country
- Efficacy of Non-surgical and Surgical Surface Decontamination Methods on Peri-implantitis-affected ImplantsEnrolling by invitationNCT06430268Not applicable1 country
- Crown Removal in Non-Surgical Peri-Implantitis Therapy: A Randomized TrialRecruitingNCT07391202Not applicable1 country
- MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal SurgeryRecruitingNCT07414498Not applicable1 country
- Peri-implantitis Implantoplasty TreatmentRecruitingNCT04052373Not applicable1 country
- Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitisRecruitingNCT05899933Not applicable1 country
- Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)RecruitingNCT06679283Not applicable1 country
- Minimally-Invasive Non-Surgical Therapy of Peri-ImplantitisRecruitingNCT07466966Not applicable1 country
- Adjunctive Keratinized Mucosa Augmentation in Peri-ImplantitisRecruitingNCT07471386Not applicable1 country
- Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen MembraneEnrolling by invitationNCT05699343Not applicable1 country
- Immediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects.RecruitingNCT07325747Not applicable1 country
- Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants.Not yet recruitingNCT07365722Not applicable
- Periodontitis and InflammationRecruitingNCT048310601 country
- Occlusal Load Distribution and Periodontal StatusNot yet recruitingNCT07199062
- Efficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-ImplantitisRecruitingNCT07191522Not applicable1 country
- Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A Randomized Clinical TrialNot yet recruitingNCT06914518Not applicable1 country
- Peri-implantitis Treatment With Chitosan BrushRecruitingNCT06830200Not applicable1 country
- Evaluation of the Effects of the Low-level Laser Therapy as an Adjunct to Nonsurgical Treatment in Patients With PeriimplantitisNot yet recruitingNCT07128134Not applicable1 country
- Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-ImplantitisRecruitingNCT07012915Not applicable1 country
- The Study on the Accuracy of Peri-implant Probing and Related Influencing FactorsRecruitingNCT070045171 country