Toothache clinical trials
The registry lists 140 studies for Toothache across more than 10 countries. 25 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-23.
Status
- Completed
- 102
- Recruiting
- 14
- Not yet recruiting
- 9
- Terminated
- 5
- Active, not recruiting
- 3
- Status unknown
- 2
Phase
- Phase 3
- 27
- Phase 2
- 25
- Phase 4
- 16
- Phase 1
- 3
- Early Phase 1
- 1
Where
- United States
- 60
- Turkey (Türkiye)
- 15
- Egypt
- 10
- France
- 8
- Brazil
- 4
- Turkey
- 4
Who runs them
Pfizer (11) · Merck Sharp & Dohme LLC (5) · GlaxoSmithKline (5) · University Hospital, Clermont-Ferrand (3) · McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. (3) · Iroko Pharmaceuticals, LLC (3) · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division (3) · Cairo University (3)
Studies
Recruiting first, then most recently updated. Showing 50 of 140 — search for more.
- Photobiomodulation and Tooth AnalgesiaRecruitingNCT06691269Not applicable1 country
- Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent.Not yet recruitingNCT077184771 country
- Local Dexamethasone Administration in Symptomatic Irreversible PulpitisRecruitingNCT07672873Not applicable1 country
- Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp TherapyNot yet recruitingNCT07595731Not applicable
- Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.Not yet recruitingNCT07600099Not applicable1 country
- An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC)RecruitingNCT06330207Not applicable1 country
- Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in ChildrenRecruitingNCT07547371Not applicable1 country
- Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic BiomarkerRecruitingNCT07452614Not applicable1 country
- Identification of Possible Trigeminal NeuralgiaNot yet recruitingNCT074535111 country
- Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental TreatmentNot yet recruitingNCT07445594Not applicable
- Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.RecruitingNCT04860141Phase 41 country
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIHRecruitingNCT07374354Not applicable1 country
- Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) ChildrenRecruitingNCT07352813Not applicable1 country
- Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible PulpitisRecruitingNCT07287709Not applicable1 country
- A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.RecruitingNCT07239505Not applicable1 country
- Anesthetic Effectiveness of Lidocaine Versus Articaine in DentistryNot yet recruitingNCT07231614Phase 41 country
- The Effect of Virtual Reality Glasses on Pain PerceptionEnrolling by invitationNCT07167394Not applicable1 country
- Comparison of Post Cementation Sensitivity Between RMGIC and GIC as Luting Materials in a Randomized Clinical TrialEnrolling by invitationNCT07102121Not applicable1 country
- Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical TrialRecruitingNCT07130760Not applicable1 country
- Evaluation of the Success Rate of Pulpotomy Versus to Root Canal Therapy in Management of Mature First Permanent Molars With Irreversible PulpitisNot yet recruitingNCT07046533Not applicable
- A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in AdultsNot yet recruitingNCT06269406Not applicable1 country
- Garlic Oil As Root Filling Material in Primary MolarsNot yet recruitingNCT06755502Not applicable
- Dental Block for Pain Relief in ED Dental Pain PatientsRecruitingNCT053510991 country
- Pain Perception Measurement by EEG and NRSRecruitingNCT065102441 country
- Drug-free Without Toothache. A Study of Free Dental Treatment as a Part of Substance Abuse TreatmentRecruitingNCT05606562Not applicable1 country
- Digital Intraosseous Anesthesia in MIH-Affected Permanent MolarsCompletedNCT07736677Not applicable1 country
- Immersive Virtual Reality for Pain and Dental Anxiety During Pediatric Restorative TreatmentCompletedNCT07781254Not applicable1 country
- Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible PulpitisActive, not recruitingNCT07761962Not applicable1 country
- Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor HypomineralizationActive, not recruitingNCT07759739Not applicable1 country
- Patient Education and AI-Assisted Complaint Summaries in Endodontic PatientsCompletedNCT07698847Not applicable1 country
- Study of the Use of Methoxyflurane vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: METODO (METhoxyflurane in ODOntology)CompletedNCT06495372Phase 31 country
- Correlation Between the Clinical Presentation of Pulp and the Biological Mediators in Gingival Crevicular Fluid and the Inflamed Pulpal TissueCompletedNCT07592455Not applicable1 country
- Comfort-in Needle-Free Injection System in Pediatric Dental AnesthesiaCompletedNCT07585812Not applicable1 country
- Sweet-Tasting Solution Versus Placebo to Reduce Pain During Local Anesthetic Injection in ChildrenCompletedNCT07279285Not applicable1 country
- Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia ToolsCompletedNCT07292194Not applicable1 country
- Evaluation of the Sedative Effect of Contextualized Music Listening on Patient Pain and Anxiety in a Dental Care SettingCompletedNCT07543042Not applicable1 country
- Comparative Evaluation of Intraligamentary Injection of Dexamethasone, Diclofenac Sodium, and Chymotrypsin for Enhancing the Success of 4% Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible PulpitisCompletedNCT07506265Phase 41 country
- Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in ChildrenCompletedNCT07366788Not applicable1 country
- Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia.CompletedNCT07426523Not applicable1 country
- Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical PeriodontitisCompletedNCT07120126Not applicable1 country
- Technology-based Distraction Techniques in Managing Children With Attention-deficit/Hyperactivity DisorderCompletedNCT07411157Not applicable1 country
- Combined Use of Potassium Nitrate Gel and Diode Laser for Dentin HypersensitivityCompletedNCT06967818Not applicable1 country
- Evaluation of Pulpal and Salivary Neuropeptides in Dental PainCompletedNCT073300241 country
- Post-Endodontic Pain According to Menstrual Cycle PhasesCompletedNCT072915181 country
- Effect of Computer-controlled vs. Conventional Injection on Pain and Anxiety in ChildrenCompletedNCT07193342Not applicable1 country
- Pain Management in Teeth With Reversible PulpitisCompletedNCT07114198Early Phase 11 country
- The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among ChildrenActive, not recruitingNCT07002528Not applicable1 country
- Intraosseous Local Anesthesia System in Children With Molar Incisor HypomineralizationSuspendedNCT06461143Not applicable1 country
- The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in ChildrenCompletedNCT06779448Not applicable1 country
- A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental PainCompletedNCT05761574Phase 31 country