Toothache clinical trials
The registry lists 142 studies for Toothache across more than 10 countries. 28 are recruiting or about to start. 100 of them are mainly about Toothache (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Who runs them
GlaxoSmithKline (6) · Bayer (5) · The University of Hong Kong (3) · Iroko Pharmaceuticals, LLC (3) · Pfizer (3) · Cairo University (3) · Damascus University (2) · AFT Pharmaceuticals, Ltd. (2)
What is being tested here
Drugs under test in Toothache studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ibuprofen | 2 | 3 | 9 |
| Carticaine | 1 | 0 | 2 |
| Allyl sulfide | 1 | 0 | 1 |
| Dexamethasone | 1 | 0 | 1 |
| Gabapentin | 1 | 0 | 1 |
| Valacyclovir | 1 | 0 | 1 |
| Acyclovir | 1 | 0 | 1 |
| Acetaminophen | 0 | 2 | 9 |
| Naproxen | 0 | 3 | 7 |
| Bupivacaine | 0 | 1 | 3 |
Drug classes tested here NSAIDs 2 open · Local anesthetics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children · Ankara Yildirim Beyazıt University
- Dec 2026Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp Therapy · Cairo University
- Dec 2026Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction. · Loma Linda University
- Dec 2026Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis · Marmara University
- Feb 2027An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC) · University of Florida
- Apr 2027Identification of Possible Trigeminal Neuralgia · University College, London
- Jun 2027Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible Pulpitis · King Abdullah University Hospital
- Jun 2027Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial · Aula Dental Avanzada
- Jun 2027Photobiomodulation and Tooth Analgesia · University of Maryland, Baltimore
- Jun 2027Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth. · Cairo University
Who these studies take
Of the 15 Toothache studies recruiting now, 4 (27%) set no upper age limit and 11 (73%) stop at 75 or younger. 7 (47%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 10 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (33%) | 5 (33%) |
| 18 | 9 (60%) | 9 (60%) |
| 30 | 10 (67%) | 10 (67%) |
| 40 | 10 (67%) | 10 (67%) |
| 50 | 9 (60%) | 9 (60%) |
| 65 | 5 (33%) | 5 (33%) |
| 75 | 4 (27%) | 4 (27%) |
| 85 | 4 (27%) | 4 (27%) |
Across all 142 studies, recruiting or not: 75% stop at 75 or younger and 74% at 65; 42% take children; 2% are for women only and 4% for men only; 44% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Toothache studies take
Of 10 phase 2 interventional studies under Toothache, half reached primary completion within 3 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 3 mo3–5 · 10 studies | — | — |
| Interventional, no phase | 5 mo3–12 · 45 studies | — | 5 mo3–15 · 44 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Results posted1
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 142. Browse all 142 → or search them.
- Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin SealerNot yet recruitingNCT07923110Not applicable1 country
- Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical TrialRecruitingNCT07130760Not applicable1 country
- A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar ExtractionRecruitingNCT07905105Phase 1/21 country
- Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent.RecruitingNCT077184771 country
- Photobiomodulation and Tooth AnalgesiaRecruitingNCT06691269Not applicable1 country
- Local Dexamethasone Administration in Symptomatic Irreversible PulpitisRecruitingNCT07672873Not applicable1 country
- Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp TherapyNot yet recruitingNCT07595731Not applicable
- Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.Not yet recruitingNCT07600099Not applicable1 country
- An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC)RecruitingNCT06330207Not applicable1 country
- Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in ChildrenRecruitingNCT07547371Not applicable1 country
- Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic BiomarkerRecruitingNCT07452614Not applicable1 country
- Identification of Possible Trigeminal NeuralgiaNot yet recruitingNCT074535111 country
- Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental TreatmentNot yet recruitingNCT07445594Not applicable
- Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.RecruitingNCT04860141Phase 41 country
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIHRecruitingNCT07374354Not applicable1 country
- Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) ChildrenRecruitingNCT07352813Not applicable1 country
- Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible PulpitisRecruitingNCT07287709Not applicable1 country
- Anesthetic Effectiveness of Lidocaine Versus Articaine in DentistryNot yet recruitingNCT07231614Phase 41 country
- The Effect of Virtual Reality Glasses on Pain PerceptionEnrolling by invitationNCT07167394Not applicable1 country
- Comparison of Post Cementation Sensitivity Between RMGIC and GIC as Luting Materials in a Randomized Clinical TrialEnrolling by invitationNCT07102121Not applicable1 country
- Evaluation of the Success Rate of Pulpotomy Versus to Root Canal Therapy in Management of Mature First Permanent Molars With Irreversible PulpitisNot yet recruitingNCT07046533Not applicable
- A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in AdultsNot yet recruitingNCT06269406Not applicable1 country
- Garlic Oil As Root Filling Material in Primary MolarsNot yet recruitingNCT06755502Not applicable
- Dental Block for Pain Relief in ED Dental Pain PatientsRecruitingNCT053510991 country
- Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult PatientsNot yet recruitingNCT06704113Phase 4
- Pain Perception Measurement by EEG and NRSRecruitingNCT065102441 country
- Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber OpeningRecruitingNCT06344195Phase 41 country
- Impact of Tramadol Addiction On Dental Anesthesia SuccessNot yet recruitingNCT05908305Phase 4
- A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental PainCompletedNCT05761574Phase 31 country
- A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.CompletedNCT07239505Not applicable1 country
- Digital Intraosseous Anesthesia in MIH-Affected Permanent MolarsCompletedNCT07736677Not applicable1 country
- Immersive Virtual Reality for Pain and Dental Anxiety During Pediatric Restorative TreatmentCompletedNCT07781254Not applicable1 country
- Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible PulpitisActive, not recruitingNCT07761962Not applicable1 country
- Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor HypomineralizationActive, not recruitingNCT07759739Not applicable1 country
- Patient Education and AI-Assisted Complaint Summaries in Endodontic PatientsCompletedNCT07698847Not applicable1 country
- Study of the Use of Methoxyflurane vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: METODO (METhoxyflurane in ODOntology)CompletedNCT06495372Phase 31 country
- Correlation Between the Clinical Presentation of Pulp and the Biological Mediators in Gingival Crevicular Fluid and the Inflamed Pulpal TissueCompletedNCT07592455Not applicable1 country
- Comfort-in Needle-Free Injection System in Pediatric Dental AnesthesiaCompletedNCT07585812Not applicable1 country
- Sweet-Tasting Solution Versus Placebo to Reduce Pain During Local Anesthetic Injection in ChildrenCompletedNCT07279285Not applicable1 country
- Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia ToolsCompletedNCT07292194Not applicable1 country
- Evaluation of the Sedative Effect of Contextualized Music Listening on Patient Pain and Anxiety in a Dental Care SettingCompletedNCT07543042Not applicable1 country
- Comparative Evaluation of Intraligamentary Injection of Dexamethasone, Diclofenac Sodium, and Chymotrypsin for Enhancing the Success of 4% Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible PulpitisCompletedNCT07506265Phase 41 country
- Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in ChildrenCompletedNCT07366788Not applicable1 country
- Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia.CompletedNCT07426523Not applicable1 country
- Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical PeriodontitisCompletedNCT07120126Not applicable1 country
- Technology-based Distraction Techniques in Managing Children With Attention-deficit/Hyperactivity DisorderCompletedNCT07411157Not applicable1 country
- Combined Use of Potassium Nitrate Gel and Diode Laser for Dentin HypersensitivityCompletedNCT06967818Not applicable1 country
- Evaluation of Pulpal and Salivary Neuropeptides in Dental PainCompletedNCT073300241 country
- Post-Endodontic Pain According to Menstrual Cycle PhasesCompletedNCT072915181 country
- Effect of Computer-controlled vs. Conventional Injection on Pain and Anxiety in ChildrenCompletedNCT07193342Not applicable1 country