Facial Pain clinical trials
The registry lists 182 studies for Facial Pain across more than 10 countries. 61 are recruiting or about to start. 76 of them are mainly about Facial Pain (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Toothache too: 323 studies, 88 open.
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Who runs them
University of Nove de Julho (5) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · Istanbul Medipol University Hospital (3) · Federal University of São Paulo (3) · UConn Health (3) · University Medical Center Goettingen (3) · Marmara University (3) · University of California, Los Angeles (3)
What is being tested here
Drugs under test in Facial Pain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lidocaine | 2 | 0 | 3 |
| Botulinum toxin type A | 1 | 0 | 3 |
| Dronabinol | 1 | 0 | 1 |
| Ketamine | 1 | 0 | 1 |
| Magnesium sulfate anhydrous | 1 | 1 | 1 |
| Magnesium Sulfate | 1 | 1 | 1 |
| Sodium Bicarbonate | 1 | 0 | 1 |
| Ibuprofen | 1 | 0 | 1 |
| Bupivacaine | 1 | 0 | 1 |
| Chlorzoxazone | 1 | 0 | 1 |
Drug classes tested here Local anesthetics 3 open · NSAIDs 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular Origin · Phase 3 · Wroclaw Medical University
- Nov 2026Burning Mouth Syndrome: Effects of Occlusal Splint Therapy · Malmö University
- Nov 2026Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur Orchestras · University Medical Center Goettingen
- Nov 2026Treatment of Atypical Resistant Facial Pain · Alenka Spindler-Vesel
- Nov 2026Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial · Mudher MB Alsunbuli
- Dec 2026Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin · Wroclaw Medical University
- Dec 2026Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial Pain · Flávio Magno Gonçalves
- Dec 2026Reflex Therapy of Temporomandibular Dysfunctions · Palacky University
- Dec 2026Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia · Riyadh Elm University
- Jan 2027Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain · Assiut University
Who these studies take
Of the 30 Facial Pain studies recruiting now, 16 (53%) set no upper age limit and 10 (33%) stop at 75 or younger. 5 (17%) take children under 18. 1 (3%) are for women only and 0 (0%) for men only; 10 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 27 (90%) | 26 (87%) |
| 30 | 29 (97%) | 28 (93%) |
| 40 | 29 (97%) | 29 (97%) |
| 50 | 28 (93%) | 28 (93%) |
| 65 | 24 (80%) | 24 (80%) |
| 75 | 20 (67%) | 20 (67%) |
| 85 | 17 (57%) | 17 (57%) |
Across all 182 studies, recruiting or not: 49% stop at 75 or younger and 37% at 65; 13% take children; 9% are for women only and 0% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Facial Pain studies take
Of 57 interventional studies with no phase under Facial Pain, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo8–35 · 57 studies | — | 17 mo8–34 · 53 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Marine Lipids Ease Painful TMDNov 5, 2026NCT07437313
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeOct 21, 2026NCT07572994
Stopped1
- The Use of tDCS in the Orofacial PainWithdrawnOct 22, 2026NCT05584384
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 182. Browse all 182 → or search them.
- Visual Instillation of Sphenopalatine-block Intervention for ONgoing MigraineNot yet recruitingNCT07764783Phase 21 country
- Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot StudyRecruitingNCT07919444Phase 21 country
- Marine Lipids Ease Painful TMDRecruitingNCT07437313Not applicable1 country
- Phenotype-based Model for Managing Chronic Post-treatment Pain Among Head and Neck Cancer Survivors: a Pilot StudyRecruitingNCT07919457Phase 21 country
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeRecruitingNCT07572994Not applicable1 country
- An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular DisordersRecruitingNCT07639944Not applicable1 country
- Botulinum Toxin Type A Versus Triamcinolone for Facial MyalgiaNot yet recruitingNCT07867379Phase 41 country
- Masticatory Muscle Activity Using a 24-Hour Wearable DeviceRecruitingNCT078619061 country
- Skills Training and Relief for Orofacial PainNot yet recruitingNCT07802067Not applicable1 country
- Treatment Validation for Myofascial PainRecruitingNCT07133139Not applicable1 country
- Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur OrchestrasRecruitingNCT077148371 country
- Lidocaine-prilocaine Cream as Analgesia for In-office Levator Muscle Trigger Point InjectionsNot yet recruitingNCT07778043Phase 4
- Deciphering Persistent Orofacial Pain - PIFPNot yet recruitingNCT077910041 country
- Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in WomenNot yet recruitingNCT07783295Phase 21 country
- Exploration of the Utility of Dental-dedicated MRI for DentistryRecruitingNCT069481621 country
- Reflex Therapy of Temporomandibular DysfunctionsRecruitingNCT07321483Not applicable1 country
- Headache Ear Auditory Dizziness Sinus (HEADS) RegistryRecruitingNCT077542661 country
- The Italian Version of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD)Not yet recruitingNCT07750509
- Efficacy of PRP Injections in Reducing Pain for Myogenous TMD PatientsNot yet recruitingNCT07606378Not applicable1 country
- Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled TrialNot yet recruitingNCT07736521Not applicable
- Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial PainNot yet recruitingNCT07706153Not applicable1 country
- Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.RecruitingNCT07187388Not applicable1 country
- Measuring Pelvic Floor Muscle Fitness Before and After TreatmentNot yet recruitingNCT07605598Not applicable1 country
- Hard Splint Vs Conservative Therapy for TMJ Pain ManagementNot yet recruitingNCT07573137Not applicable
- Comparison of Patient-reported Pain After Initial Archwire PlacementRecruitingNCT03906422Not applicable1 country
- Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain ManagementRecruitingNCT04059172Early Phase 11 country
- Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial PainRecruitingNCT04930887Phase 21 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- Identification of Possible Trigeminal NeuralgiaNot yet recruitingNCT074535111 country
- Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular DisordersRecruitingNCT07474662Not applicable1 country
- Effectiveness of Photobiomodulation for Myofascial Pain in Temporomandibular DisordersNot yet recruitingNCT07460895Not applicable
- The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular OriginEnrolling by invitationNCT05961501Phase 2/31 country
- Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle OriginEnrolling by invitationNCT064056461 country
- Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial PainEnrolling by invitationNCT07352384Not applicable1 country
- Burning Mouth Syndrome: Effects of Occlusal Splint TherapyNot yet recruitingNCT07344909Not applicable1 country
- Somatosensory Training Versus Exercise Therapy in Awake BruxismRecruitingNCT07336082Not applicable1 country
- Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue FunctionsRecruitingNCT07304557Not applicable1 country
- Treatment of Atypical Resistant Facial PainEnrolling by invitationNCT072509841 country
- Orofacial Pain Self-management: Personality Moderation EffectRecruitingNCT06932406Not applicable1 country
- Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial PainNot yet recruitingNCT07250867Phase 2
- Myofascial Release Wıth Hamstring ShortnessNot yet recruitingNCT07174258Not applicable
- Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular ConflictNot yet recruitingNCT071350242 countries
- Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism PainRecruitingNCT07109882Phase 41 country
- ePROPP - eHealth for Preventing and Reducing Orofacial Pain in the PopulationNot yet recruitingNCT07095101Not applicable
- Effects of Photobiomodulation With Superpulsed Laser and Dual Wavelengths in Children and AdolescentsNot yet recruitingNCT07031505Not applicable
- Validation and Evaluation of the Mastication Function in Adults: The Functional Six-minute Mastication Test (F-6MMT).Not yet recruitingNCT062987861 country
- Prevalence of Temporomandibular Joint Disorders in Wind MusiciansNot yet recruitingNCT06823531
- Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber DamNot yet recruitingNCT06487819Not applicable1 country
- Comparison of Pulsed and Thermal Radiofrequency for Trigeminal NeuralgiaRecruitingNCT06684275Not applicable1 country
- Comparison Between Botox and Magnesium Sulfate Effect in Treatment of Myofascial Pain Trigger Points Within the Masseter MuscleNot yet recruitingNCT06676475Phase 2/31 country