An interventional study of Garlic oil and Calcium Hydroxide, Iodoform, paste in Irreversible Pulpitis (toothache), sponsored by Cairo University. Not yet recruiting. Open to participants aged 4 Years to 8 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-20.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.
the study hypothesized that garlic oil mixed with zinc oxide would be the same as the gold standard filling material (metapex).
The group receiving the garlic oil with zinc oxide as root canal filling material will be compared with other similar group receiving metapex as root canal filling material in terms of clinical and radio-graphic success, and working time.
This study is a randomized clinical trial (RCT), that aims compare the clinical and radio-graphic success of garlic oil mixed with zinc oxide, used as root canal filling material in primary molars in children aged from four to eight years, with the conventional root filling material, which is metapex.
142 studies on the registry are indexed under Toothache; 28 are open to participants now.
This study's planned enrollment of 40 is below the median of 84 across 123 interventional studies indexed under Toothache.
Browse Toothache studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
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Combination Product: Garlic oil
Drug: Calcium Hydroxide, Iodoform, paste
garlic oil mixed with zinc oxid powder, as root canal filling material
Drug pages: Calcium Hydroxide · Iodoform
Metapex as root canal filling materials
Also known as: metapex
The clinical success rate
The criteria of successful treatment, according to which the clinical evaluation will be done, will be "No abnormal mobility", "No sensitivity to percussion", and "No swelling"
Time frame: 3, 6,9,and 12 months
Radio-graphic success
For the radiographic success, the evaluation criteria will be "Preoperative pathological inter-radicular and/or periapical radiolucency started to resolve, or remained the same size", "No new postoperative pathological radiolucency developed", and "No pathological internal or external root resorption"
Time frame: 6, and 12 month.
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Aug 2025; primary completion for Oct 2026, 14 months later.
Of 44 non-industry interventional studies with no phase under Toothache, half reached primary completion within 5 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 15. This study's planned 14 months is above that.
Counting every sponsor, half of 45 studies reached it within 5 months; a quarter within 3 and three quarters within 12.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Allyl sulfide