An interventional study of magnesium sulfate and standard care treatment in Septic Shock and Sepsis, sponsored by Alexandria University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-06.
Sponsored by Alexandria University · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to assess the effect of targeting upper normal serum magnesium levels on norepinephrine requirements in adult patients with septic shock.
The main questions it aims to answer are:
This study will compare an intervention group to a control group to see the effect of targeting upper normal serum magnesium levels.
Participants will:
1,078 studies on the registry are indexed under Shock, Septic; 232 are open to participants now.
This study's planned enrollment of 60 is below the median of 79 across 636 interventional studies indexed under Shock, Septic.
Browse Shock, Septic studies →Alexandria University is the lead sponsor of 604 studies on the registry; 140 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
How quickly the kidneys clear creatinine, a waste product, from the blood. A study may estimate it from a blood test with age, weight and sex (often by the Cockcroft–Gault formula), or measure it using blood and urine collected over a set time. Given in mL/min; higher is better.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Creatinine clearance (CrCl)
How quickly the kidneys clear creatinine, a waste product, from the blood. A study may estimate it from a blood test with age, weight and sex (often by the Cockcroft–Gault formula), or measure it using blood and urine collected over a set time. Given in mL/min; higher is better.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will receive intravenous magnesium sulfate infusion to achieve and maintain upper normal serum magnesium levels (2.0 - 2.3 mg/dL).
Drug: magnesium sulfate
Patients will receive standard care to maintain serum magnesium levels (1.7 - 1.9 mg/dL).
Other: standard care treatment
Intravenous magnesium sulfate infusions will be individualized and administered to achieve and maintain the target serum magnesium levels.
Patients will receive standard care required to maintain the target serum magnesium levels.
Total cumulative dose of norepinephrine
Total cumulative dose of norepinephrine administered to the patient, measured in µg/kg.
Time frame: Up to 60 days.
Duration of norepinephrine therapy
The time from the initiation of norepinephrine until discontinuation, measured in hours.
Time frame: Up to 60 days.
ICU length of stay
Length of stay in the ICU, measured in days.
Time frame: Up to 60 days.
Duration of mechanical ventilation
Duration of mechanical ventilation, measured in days.
Time frame: Up to 60 days.
Mortality
Time frame: Up to 60 days.
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Studies of the drug tested here: Magnesium Sulfate