Sepsis clinical trials
The registry lists 2,416 studies for Sepsis across more than 10 countries. 541 are recruiting or about to start. 1,365 of them are mainly about Sepsis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 8 narrower conditions too, such as Shock, Septic: 3,525 studies, 738 open.
ClinicalTrials.gov finds 3,872 studies for Sepsis. How that becomes 2,414 here
This page counts the studies the registry files under Sepsis, and those it files under no condition that list Sepsisthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 3,872Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,054Filed under a narrower condition, counted on its own pageShock, Septic 516 · Bacteremia 180 · Neonatal Sepsis 155 · Endotoxemia 62 · Candidemia 60 · Viremia 36 · 2 more
- −118List Sepsis as a condition, but the registry did not file them under itMost often written as “Sepsis Syndrome” (12), “Abdominal Sepsis” (11), and “Central Line-associated Bloodstream Infection (CLABSI)” (8). The registry filed them under other conditions only, most often Intraabdominal Infections (14) and Systemic Inflammatory Response Syndrome (13).
- −286Match it another way171 name it in the title, 21 in a keyword, and 94 by a synonym or other text the search reads.
- 2,414The count on this page107 of them list Sepsis in their own words; the registry filed them under no condition.
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· Enrollment: 300 → 450 participants
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Who runs them
Assistance Publique - Hôpitaux de Paris (34) · Assiut University (33) · Ain Shams University (30) · National Taiwan University Hospital (23) · Southeast University, China (21) · Tanta University (21) · Chinese PLA General Hospital (20) · Mayo Clinic (16)
What is being tested here
Drugs under test in Sepsis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Meropenem | 4 | 7 | 16 |
| Dexmedetomidine | 4 | 2 | 14 |
| Norepinephrine | 4 | 5 | 12 |
| Hydrocortisone | 3 | 8 | 18 |
| Heparin | 3 | 4 | 8 |
| Fludrocortisone | 3 | 1 | 4 |
| Nafamostat | 3 | 0 | 3 |
| Ascorbic Acid | 2 | 8 | 34 |
| Ceftriaxone | 2 | 2 | 7 |
| Angiotensin II | 2 | 1 | 6 |
Drug classes tested here Corticosteroids 6 open · Beta-lactamase inhibitors 5 open · Inhaled anesthetics 2 open · Beta blockers 1 open · Diuretics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Early Vasopressors in Sepsis · Phase 3 · NHS Greater Glasgow and Clyde
- Dec 2026A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections · Phase 3 · Angela HUTTNER
- Dec 2026Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infections · Phase 3 · Qilu Pharmaceutical Co., Ltd.
- Jan 2027Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis · Phase 3 · Assiut University
- Jul 2027Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients · Phase 3 · Hospices Civils de Lyon
- Oct 2027Effect of Adjunctive Ursodeoxycholic Acid on Oxidative Stress, Inflammation, and Organ Dysfunction in Adults With Sepsis · Phase 3 · Tanta University
- Nov 2026Emapalumab Treatment For Anticipated Clinical Benefit In Sepsis Driven By The Interferon-Gamma Endotype (The EMBRACE Trial) · Hellenic Institute for the Study of Sepsis
- Nov 2026Serial Platelet Count and Indices for Predicting In-Hospital Mortality in Sepsis · Assiut University
- Nov 2026Early Optimization of Ceftazidime Regimen in Critical Care · Centre Hospitalier Universitaire de Saint Etienne
- Nov 2026Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis · Egemen Yildiz
Who these studies take
Of the 318 Sepsis studies recruiting now, 213 (67%) set no upper age limit and 53 (17%) stop at 75 or younger. 68 (21%) take children under 18. 1 (<1%) are for women only and 2 (1%) for men only; 42 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 50 (16%) | 50 (16%) |
| 18 | 273 (86%) | 273 (86%) |
| 30 | 275 (86%) | 275 (86%) |
| 40 | 275 (86%) | 274 (86%) |
| 50 | 277 (87%) | 277 (87%) |
| 65 | 275 (86%) | 275 (86%) |
| 75 | 269 (85%) | 269 (85%) |
| 85 | 251 (79%) | 250 (79%) |
Across all 2,416 studies, recruiting or not: 19% stop at 75 or younger and 16% at 65; 20% take children; 1% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Sepsis studies take
Of 66 phase 3 interventional studies under Sepsis, half reached primary completion within 39 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 12 mo6–28 · 32 studies | — | — |
| Phase 2 | 29 mo17–37 · 60 studies | — | 30 mo16–35 · 43 studies |
| Phase 2/3 | 33 mo16–88 · 18 studies | — | — |
| Phase 3 | 39 mo24–65 · 66 studies | — | 42 mo24–68 · 58 studies |
| Phase 4 | 25 mo15–43 · 66 studies | — | 25 mo15–45 · 65 studies |
| Interventional, no phase | 22 mo12–40 · 324 studies | — | 23 mo12–42 · 301 studies |
| Observational | 27 mo12–56 · 543 studies | 16 mo6–44 · 52 studies | 29 mo13–58 · 491 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting6
- Hyperinflammation and Hyperferritinemia in Critically Ill PatientsNov 10, 2026NCT06820905
- Oral Switch in Bloodstream Infections in Immunocompromised ChildrenNov 10, 2026NCT07923266
- A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric PatientsNov 6, 2026NCT07484633
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyOct 28, 2026NCT07896018
- Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm NeonatesOct 27, 2026NCT06377397
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- Oral Switch in Pediatric Bloodstream InfectionsOct 19, 2026NCT07791914
Results posted1
Stopped2
- LUNG INFECTION IN ICU (LUNG-I3)TerminatedOct 30, 2026NCT06073834
- Integrated Clinical Decision Support for Empiric Antibiotic Selection in SepsisTerminatedOct 19, 2026NCT06103500
Newly registered26
- Viscoelastic Coagulation Monitoring for Early Identification of Sepsis: The VISION II StudyNov 10, 2026NCT07927621
- AI-ECHO Hemodynamic Phenotyping in Septic ShockNov 9, 2026NCT07924501
- Integrated Medicine for Sepsis: An RCT With PhenotypingNov 6, 2026NCT07920692
- Effect of Rutin and Vitamin C on Outcomes in Adults With Sepsis Admitted to the Intensive Care UnitNov 6, 2026NCT07922213
- Thymosin Alpha 1 and IgM Levels in SepsisNov 6, 2026NCT07922954
Show 21 moreShow fewer
- Oral Switch in Bloodstream Infections in Immunocompromised ChildrenNov 6, 2026NCT07923266
- Evaluation of an AI-Assisted Tool for CLABSI Surveillance at VA Medical CentersNov 5, 2026NCT07918352
- Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic CareNov 5, 2026NCT07920237
- Longitudinal Trajectories of Myocardial Work in Patients With SepsisNov 4, 2026NCT07915869
- PF-Organized Corticosteroid-Associated Heterogeneity in SepsisNov 3, 2026NCT07913464
- Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn PatientsNov 3, 2026NCT07914205
- MetAbolic Changes in the SepSis LIVErNov 2, 2026NCT07910786
- Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in SepsisOct 30, 2026NCT07906561
- Middle East Study of Infections in Patients With Hematological MalignanciesOct 28, 2026NCT07900542
- Xuanbai Yiqi Decoction for Sepsis: A Randomized Controlled TrialOct 28, 2026NCT07902024
- Safflower (Carthamus Tinctorius L.) Granules for Sepsis-associated CoagulopathyOct 27, 2026NCT07897006
- A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic ResponseOct 27, 2026NCT07898462
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyOct 26, 2026NCT07896018
- Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and SepsisOct 23, 2026NCT07892794
- Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial FluidOct 23, 2026NCT07893223
- Neutrophil Activation and NETosis in SepsisOct 22, 2026NCT07888036
- Quality of Life in Patients With Post-Sepsis SyndromeOct 22, 2026NCT07889804
- Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic ShockOct 21, 2026NCT07887854
- Novel Antimicrobial Solution to Prevent InfectionsOct 19, 2026NCT07881822
- Clinical Outcomes Using Molecular Prediction in Acute Suspected Sepsis and InfectionOct 15, 2026NCT07874698
- Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic ShockOct 13, 2026NCT07871305
Studies
Recruiting first, then most recently updated. Showing 50 of 2,416. Browse all 2,416 → or search them.
- UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical TrialRecruitingNCT06779617Not applicable1 country
- Viscoelastic Coagulation Monitoring for Early Identification of Sepsis: The VISION II StudyNot yet recruitingNCT079276211 country
- Hyperinflammation and Hyperferritinemia in Critically Ill PatientsRecruitingNCT068209051 country
- Oral Switch in Bloodstream Infections in Immunocompromised ChildrenRecruitingNCT07923266Phase 41 country
- A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced CoagulopathyRecruitingNCT06854640Phase 15 countries
- AI-ECHO Hemodynamic Phenotyping in Septic ShockNot yet recruitingNCT079245011 country
- Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled TrialNot yet recruitingNCT07184866Not applicable
- Effect of Rutin and Vitamin C on Outcomes in Adults With Sepsis Admitted to the Intensive Care UnitRecruitingNCT07922213Not applicable1 country
- Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)Not yet recruitingNCT07178366Not applicable
- A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric PatientsRecruitingNCT07484633Phase 41 country
- Integrated Medicine for Sepsis: An RCT With PhenotypingNot yet recruitingNCT07920692Not applicable1 country
- ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their CaregiversNot yet recruitingNCT07778004Not applicable1 country
- THE ROLE OF PANCREATIC STONE PROTEIN (PSP) AND PSP-GUIDED EARLY MEROPENEM TREATMENT TO MITIGATE SEPSIS RISK AT THE EMERGENCY DEPARTMENT: THE PROMISE DOUBLE BLIND, PHASE III, RANDOMIZED CONTROLLED CLINICAL TRIALRecruitingNCT07813767Phase 31 country
- Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic CareNot yet recruitingNCT07920237
- Evaluation of an AI-Assisted Tool for CLABSI Surveillance at VA Medical CentersNot yet recruitingNCT07918352Not applicable
- Longitudinal Trajectories of Myocardial Work in Patients With SepsisNot yet recruitingNCT07915869
- KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill PatientsRecruitingNCT07211620Not applicable1 country
- CLARITHROMYCIN TO PREVENT SECONDARY INFECTIONS IN PATIENTS WITH SEPSIS FOLLOWING LOWER RESPIRATORY TRACT INFECTIONS: THE CLASSIFY TRIALRecruitingNCT07834346Phase 31 country
- Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn PatientsRecruitingNCT079142051 country
- Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS MembraneRecruitingNCT064403171 country
- Personalized Metabolic Nutrition Sepsis StudyNot yet recruitingNCT07910591Not applicable1 country
- Middle East Study of Infections in Patients With Hematological MalignanciesRecruitingNCT079005425 countries
- A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic ResponseRecruitingNCT07898462Phase 31 country
- Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in SepsisNot yet recruitingNCT07906561
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyRecruitingNCT078960181 country
- Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic ShockRecruitingNCT07179276Not applicable1 country
- Aminoglycosides in Early SepsisRecruitingNCT06712641Phase 41 country
- Xuanbai Yiqi Decoction for Sepsis: A Randomized Controlled TrialNot yet recruitingNCT07902024Not applicable1 country
- Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic ShockNot yet recruitingNCT07481097Not applicable1 country
- Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm NeonatesRecruitingNCT06377397Phase 31 country
- Metabolic and Functional Study of γδ T Cells in Critically Ill PatientsRecruitingNCT076808161 country
- Safflower (Carthamus Tinctorius L.) Granules for Sepsis-associated CoagulopathyNot yet recruitingNCT07897006Not applicable1 country
- Blood Purification in Septic ChildrenNot yet recruitingNCT05595239Not applicable1 country
- Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for SepsisRecruitingNCT07074028Not applicable1 country
- Comparison of Sepsis Prediction AlgorithmsNot yet recruitingNCT059439381 country
- Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial FluidNot yet recruitingNCT078932231 country
- Novel Antimicrobial Solution to Prevent InfectionsNot yet recruitingNCT07881822
- Quality of Life in Patients With Post-Sepsis SyndromeNot yet recruitingNCT078898041 country
- Neutrophil Activation and NETosis in SepsisNot yet recruitingNCT07888036
- Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic ShockRecruitingNCT06481410Not applicable1 country
- Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic ShockNot yet recruitingNCT07887854Not applicable
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket TrialRecruitingNCT06381661Phase 21 country
- Clinical Outcomes Using Molecular Prediction in Acute Suspected Sepsis and InfectionNot yet recruitingNCT07874698
- Oral Switch in Pediatric Bloodstream InfectionsRecruitingNCT07791914Phase 41 country
- Evaluating the Accuracy of Multiple Blood Tests to Diagnose Sepsis in Adult Burn PatientsEnrolling by invitationNCT071265741 country
- Prediction and Prevention of Bloodstream Infections After Kidney TransplantationNot yet recruitingNCT07407673Phase 31 country
- The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)RecruitingNCT07556107Phase 41 country
- Pre-induction Norepinephrine in Septic Patients Undergoing SurgeryNot yet recruitingNCT07869693Not applicable
- Peripheral Perfusion Index Trajectory to Predict 28-Day Mortality in Patients With Sepsis in the Intensive Care UnitRecruitingNCT077403041 country